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Pes1
Gene Detail
 Symbol
Name
ID
Pes1
pescadillo homolog 1, containing BRCT domain (zebrafish)
MGI:1890613
Feature Type protein coding gene
Genetic Map
Chromosome 11
2.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:3963975-3980004 bp, + strand
From VEGA annotation of GRCm38

  16030 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pes1

Human
homologs
Human Homolog PES1, pescadillo ribosomal biogenesis factor 1
NCBI Gene ID 23481
neXtProt AC  NX_O00541
Human Synonyms  PES
Human Chr (Location)  22q12.1; chr22:30576625-30607013 (-)  GRCh38
Alleles
and
phenotypes
All alleles(23) : Gene trapped(19) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disuption of the mouse gene results in embryonic arrest at morula stages of development, as well as failure of nucleologenesis and disruption of ribosome biogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell proliferation, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ...
Component chromosome, condensed chromosome, ...
Function poly(A) RNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (10)   
Theiler Stages: 19, 28
Assay TypeResults
RNA in situ 2
Northern blot 8
cDNA source data(160)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(161) cDNA(160) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005041 (Evidence)
Ensembl Gene ModelENSMUSG00000020430 (Evidence)
Entrez Gene64934 (Evidence)
UniGene28659
DFCITC1572589
DoTSDT.101401508, DT.110858719, DT.489904
NIA Mouse Gene IndexU012260, U094759, U163755, U363356
Consensus CDS ProjectCCDS24372.1
International Mouse Knockout Project StatusPes1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005041 VEGA Gene Model | MGI Sequence Detail 16030 C57BL/6J ±  kb
transcript OTTMUST00000011216 VEGA | MGI Sequence Detail 2923 Not Applicable 
polypeptide OTTMUSP00000005229 VEGA | MGI Sequence Detail 588 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR010613 Pescadillo
Protein Ontology PR:000012552 pescadillo
References (Earliest) J:66220 Haque J, et al., The murine pes1 gene encodes a nuclear protein containing a BRCT domain. Genomics. 2000 Dec 1;70(2):201-10
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory