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Pes1 Gene Detail
Summary
  • Symbol
    Pes1
  • Name
    pescadillo ribosomal biogenesis factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890613
    NCBI Gene: 64934
  • Gene Overview
    MyGene.info: PES1
Location & Maps
more
  • Sequence Map
    Chr11:3963975-3980004 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16030 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.79 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PES1, pescadillo ribosomal biogenesis factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PES1, pescadillo ribosomal biogenesis factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PES
  • Links
    NCBI Gene ID: 23481
    neXtProt AC: NX_O00541

  • Chr Location
    22q12.1; chr22:30576625-30607013 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5984
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PES1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Targeted disuption of the mouse gene results in embryonic arrest at morula stages of development, as well as failure of nucleologenesis and disruption of ribosome biogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005041 VEGA Gene Model | MGI Sequence Detail 16030 C57BL/6J ±  kb
transcript OTTMUST00000011216 VEGA | MGI Sequence Detail 2923 Not Applicable  
polypeptide OTTMUSP00000005229 VEGA | MGI Sequence Detail 588 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    9 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 161
    cDNA 160
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:66220 Haque J, et al., The murine pes1 gene encodes a nuclear protein containing a BRCT domain. Genomics. 2000 Dec 1;70(2):201-10
  • Latest
    J:218306 Wang M, et al., Two orthogonal cleavages separate subunit RNAs in mouse ribosome biogenesis. Nucleic Acids Res. 2014;42(17):11180-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory