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Gabarapl2 Gene Detail
Summary
  • Symbol
    Gabarapl2
  • Name
    gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2
  • Synonyms
    0610012F20Rik, 2900019O08Rik, GATE-16, Gef2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890602
    NCBI Gene: 93739
  • Gene Overview
    MyGene.info: GABARAPL2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:111940703-111953612 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12910 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 58.19 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GABARAPL2, GABA type A receptor associated protein like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GABARAPL2, GABA type A receptor associated protein like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATG8, ATG8C, GATE16, GATE-16, GEF2, GEF-2
  • Links
    NCBI Gene ID: 11345
    neXtProt AC: NX_P60520
    UniProt: P60520

  • Chr Location
    16q23.1; chr16:75566351-75577881 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031074 VEGA Gene Model | MGI Sequence Detail 12910 C57BL/6J ±  kb
    transcript OTTMUST00000076980 VEGA | MGI Sequence Detail 1677 Not Applicable  
    polypeptide OTTMUSP00000040592 VEGA | MGI Sequence Detail 117 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      111 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007759 gamma-aminobutyric acid receptor-associated protein-like 2
    • InterPro Domains
      IPR004241 Autophagy protein Atg8 ubiquitin-like
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1861743, MGI:1915608, MGI:1920098, MGI:2142469
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:63409 Kneussel M, et al., The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8594-9
    • Latest
      J:258924 Sasai M, et al., Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense. Nat Immunol. 2017 Aug;18(8):899-910

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory