About   Help   FAQ
Srsf4 Gene Detail
Summary
  • Symbol
    Srsf4
  • Name
    serine/arginine-rich splicing factor 4
  • Synonyms
    5730499P16Rik, MNCb-2616, Sfrs4, SRp75
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890577
    NCBI Gene: 57317
  • Gene Overview
    MyGene.info: SRSF4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:131873617-131901706 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 64.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890577
protein coding gene Chr4:131873612-131901725 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028859
protein coding gene Chr4:133987983-134015906 (+)
A/J MGP_AJ_G0028818
protein coding gene Chr4:128419996-128446982 (+)
AKR/J MGP_AKRJ_G0028771
protein coding gene Chr4:132015775-132044090 (+)
BALB/cJ MGP_BALBcJ_G0028841
protein coding gene Chr4:129033020-129060810 (+)
C3H/HeJ MGP_C3HHeJ_G0028555
protein coding gene Chr4:132267904-132295149 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029283
protein coding gene Chr4:138802121-138831483 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026555
protein coding gene Chr4:121514528-121542632 (+)
CAST/EiJ MGP_CASTEiJ_G0027988
protein coding gene Chr4:130334324-130363540 (+)
CBA/J MGP_CBAJ_G0028521
protein coding gene Chr4:142345159-142378035 (+)
DBA/2J MGP_DBA2J_G0028670
protein coding gene Chr4:128843555-128870843 (+)
FVB/NJ MGP_FVBNJ_G0028637
protein coding gene Chr4:127694366-127721359 (+)
LP/J MGP_LPJ_G0028771
protein coding gene Chr4:134144507-134173156 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028663
protein coding gene Chr4:146989808-147018786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029321
protein coding gene Chr4:132409185-132439989 (+)
PWK/PhJ MGP_PWKPhJ_G0027709
protein coding gene Chr4:125512704-125540257 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027535
protein coding gene Chr4:128295986-128323269 (+)
WSB/EiJ MGP_WSBEiJ_G0028068
protein coding gene Chr4:132589693-132618944 (+)



Homology
more
  • Human Ortholog
    SRSF4, serine and arginine rich splicing factor 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SRSF4, serine and arginine rich splicing factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SFRS4, SRP75
  • Links
    NCBI Gene ID: 6429
    neXtProt AC: NX_Q08170
    UniProt: Q08170

  • Chr Location
    1p35.3; chr1:29147738-29182125 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028911 Ensembl Gene Model | MGI Sequence Detail 28090 C57BL/6J ±  kb
    transcript ENSMUST00000053819 Ensembl | MGI Sequence Detail 2257 Not Applicable  
    polypeptide ENSMUSP00000061474 Ensembl | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR035585 Serine/arginine-rich splicing factor SRSF4-like, RNA recognition motif 1
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913899, MGI:2140593
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory