Wasf1
Gene Detail

Symbol Name ID

Wasf1 WAS protein family, member 1 MGI:1890563

Synonyms

Scar, WAVE, WAVE-1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

22.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr10:40883475-40938570 bp, + strand From VEGA annotation of GRCm38   55096 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2920  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Wiskott-Aldrich syndrome protein
Gene Tree: Wasf1

Human homologs

Human Homolog		WASF1, WAS protein family, member 1
NCBI Gene ID		8936
neXtProt AC		NX_Q92558
Human Synonyms		SCAR1, WAVE, WAVE1
Human Chr (Location)		6q21; chr6:110421022-110501207 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(63) : Targeted(4) Gene trapped(59)
 

Mutation of this gene has been associated with both morphological and functional defects of the central nervous system. Targeted mutagenesis has resulted in mice that display sensorimotor and cognitive defects similar to those exhibited by patients with 3p-syndrome mental retardation.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	lamellipodium morphogenesis
Component	cytoplasm, cytoskeleton, ...
Function	actin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (76)    Tissues (24)    Images (22)
Theiler Stages: 10, 15, 18, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	62
RT-PCR	12

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020871 (Evidence)
Ensembl Gene Model	ENSMUSG00000019831 (Evidence)
Entrez Gene	83767 (Evidence)
UniGene	41353
DFCI	TC1580088
DoTS	DT.55234412, DT.60104105
NIA Mouse Gene Index	U011428
Consensus CDS Project	CCDS23801.1
International Mouse Knockout Project Status	Wasf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020871	VEGA Gene Model | MGI Sequence Detail	55096	C57BL/6J
transcript	OTTMUST00000049348	VEGA | MGI Sequence Detail	2719	Not Applicable
polypeptide	OTTMUSP00000022841	VEGA | MGI Sequence Detail	559	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(229 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003124	WH2 domain
Protein Ontology	PR:000017372	Wiskott-Aldrich syndrome protein family member 1

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:180006 Yokoyama K, et al., NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J. 2011 Nov 30;30(23):4739-54
All references(55)

Other accession IDs

MGI:2143538, MGI:2143675