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Lin28a Gene Detail
Summary
  • Symbol
    Lin28a
  • Name
    lin-28 homolog A (C. elegans)
  • Synonyms
    Lin28, Lin-28, Lin28a, Tex17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890546
    NCBI Gene: 83557
  • Gene Overview
    MyGene.info: LIN28A
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:134003330-134018841 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890546
protein coding gene Chr4:134003330-134019202 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028908
protein coding gene Chr4:136317262-136333864 (-)
A/J MGP_AJ_G0028867
protein coding gene Chr4:130583618-130604141 (-)
AKR/J MGP_AKRJ_G0028819
protein coding gene Chr4:134327091-134349454 (-)
BALB/cJ MGP_BALBcJ_G0028890
protein coding gene Chr4:131232638-131249119 (-)
C3H/HeJ MGP_C3HHeJ_G0028604
protein coding gene Chr4:134567783-134582688 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029332
protein coding gene Chr4:141236778-141254628 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026603
protein coding gene Chr4:123655712-123671388 (-)
CAST/EiJ MGP_CASTEiJ_G0028037
protein coding gene Chr4:132679059-132698883 (-)
CBA/J MGP_CBAJ_G0028569
protein coding gene Chr4:144925824-144947883 (-)
DBA/2J MGP_DBA2J_G0028718
protein coding gene Chr4:131015848-131035128 (-)
FVB/NJ MGP_FVBNJ_G0028686
protein coding gene Chr4:129904014-129925910 (-)
LP/J MGP_LPJ_G0028819
protein coding gene Chr4:136410841-136428061 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028711
protein coding gene Chr4:149429690-149452514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029370
protein coding gene Chr4:134759800-134775125 (-)
PWK/PhJ MGP_PWKPhJ_G0027757
protein coding gene Chr4:127733071-127751807 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027583
protein coding gene Chr4:130594649-130610587 (-)
WSB/EiJ MGP_WSBEiJ_G0028116
protein coding gene Chr4:134925058-134944559 (-)



Homology
more
  • Human Ortholog
    LIN28A, lin-28 homolog A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LIN28A, lin-28 homolog A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSDD1, LIN28, LIN-28, lin-28A, ZCCHC1
  • Links
    NCBI Gene ID: 79727
    neXtProt AC: NX_Q9H9Z2
    UniProt: Q9H9Z2

  • Chr Location
    1p36.11; chr1:26410768-26429728 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Lin28a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 6 alleles in 10 genetic backgrounds
    9 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased birth weight and postnatal lethality. In another report, mice homozygous for the same or an identical allele exhibit reduced premordial germ cells and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050966 Ensembl Gene Model | MGI Sequence Detail 15512 C57BL/6J ±  kb
    transcript ENSMUST00000051674 Ensembl | MGI Sequence Detail 3505 Not Applicable  
    polypeptide ENSMUSP00000050488 Ensembl | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 27
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140415
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 17
      Phenotypes 27
    • Earliest
      J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
    • Latest
      J:264386 Xia X, et al., Lin28a regulates neurogliogenesis in mammalian retina through the Igf signaling. Dev Biol. 2018 Aug 15;440(2):113-128

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory