Plin1
Gene Detail

Symbol

Name
ID

Plin1
perilipin 1
MGI:1890505

Synonyms

6030432J05Rik, Peri, perilipin A, perilipin B, Plin

Feature Type

protein coding gene

Genetic Map

Chromosome 7
45.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:79721164-79732776 bp, - strand From NCBI annotation of GRCm38   11613 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lipid droplet-associated protein, perilipin type
Gene Tree: Plin1

Human
homologs

Human Homolog		PLIN1, perilipin 1
NCBI Gene ID		5346
neXtProt AC		NX_O60240
Human Synonyms		FPLD4, PERI, PLIN
Human Chr (Location)		15q26; chr15:89664367-89679417 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human PLIN1

Mutations,
alleles, and
phenotypes

All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous inactivation of this gene leads to increased lean body mass and altered adipocyte lipolysis, leptin production and susceptibility to diet-induced obesity. Increased oxygen and food consumption, impaired cold adaptation, and altered glucose and blood homeostasis have also been observed.

 

Interactions

Plin1 interacts with 47 markers (Mir19a, Mir129-2, Mir182, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (7 annotations)

Process	lipid catabolic process, lipid metabolic process
Component	cytosol, endoplasmic reticulum, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	3

cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(22) cDNA(22)
Microarray probesets(2)

Other database
links

Ensembl Gene Model	ENSMUSG00000030546 (Evidence)
Entrez Gene	103968 (Evidence)
UniGene	254917
DFCI	TC1586310, TC1638355, TC1611413, TC1615867
DoTS	DT.533984, DT.55252902, DT.91366491, DT.91418512
NIA Mouse Gene Index	U042825
Consensus CDS Project	CCDS21385.1
International Mouse Knockout Project Status	Plin1

Sequences

Length	Strain/Species
genomic	103968	NCBI Gene Model | MGI Sequence Detail	11613	C57BL/6J
transcript	NM_175640	RefSeq | MGI Sequence Detail	1935	C57BL/6
polypeptide	Q8CGN5	UniProt | EBI | MGI Sequence Detail	517	Not Applicable

All sequences(30) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(1) : SNPs within 2kb(128 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004279	Perilipin
Protein Ontology	PR:000012869	perilipin-1

Graphical View of Protein Domain Structure

References

(Earliest) J:66267 Martinez-Botas J, et al., Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice. Nat Genet. 2000 Dec;26(4):474-9
(Latest) J:212396 Chen M, et al., PLIN1 deficiency affects testicular gene expression at the meiotic stage in the first wave of spermatogenesis. Gene. 2014 Jun 15;543(2):212-9
All references(54)

Other
accession IDs

MGI:2444270