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Plin1
Gene Detail
Symbol

Name
ID
Plin1
perilipin 1
MGI:1890505
Synonyms
6030432J05Rik, Peri, perilipin A, perilipin B, Plin
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:79721164-79732776 bp, - strand
From Ensembl annotation of GRCm38

  11613 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PLIN1
Protein SuperFamily: lipid droplet-associated protein, perilipin type
Gene Tree: Plin1

Human
homologs
PLIN1, perilipin 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5346
neXtProt AC: NX_O60240

Human Synonyms: FPLD4, PERI, PLIN

Human Chr (Location): 15q26; chr15:89664365-89679417 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLIN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to increased lean body mass and altered adipocyte lipolysis, leptin production and susceptibility to diet-induced obesity. Increased oxygen and food consumption, impaired cold adaptation, and altered glucose and blood homeostasis have also been observed.
 
Interactions
Plin1 interacts with 47 markers (Mir19a, Mir129-2, Mir182, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process lipid catabolic process, lipid metabolic process
Component cytosol, endoplasmic reticulum, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plin1    NEW 
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030546 (Evidence)
Entrez Gene 103968 (Evidence)
UniGene 254917
DFCI TC1638355, TC1586310, TC1615867, TC1611413
DoTS DT.91418512, DT.91366491, DT.55252902, DT.533984
NIA Mouse Gene Index U042825
Consensus CDS Project CCDS21385.1
International Mouse Phenotyping Consortium Status Plin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030546 Ensembl Gene Model | MGI Sequence Detail 11613 C57BL/6J ±  kb
transcript ENSMUST00000032762 Ensembl | MGI Sequence Detail 1916 Not Applicable 
polypeptide ENSMUSP00000032762 Ensembl | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004279 Perilipin
Protein Ontology PR:000012869 perilipin-1
References
(Earliest) J:66267 Martinez-Botas J, et al., Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice. Nat Genet. 2000 Dec;26(4):474-9
(Latest) J:216370 Wang W, et al., Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14466-71
All references(54)
Other
accession IDs
MGI:2444270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory