Plin1 MGI Mouse Gene Detail - MGI:1890505

Plin1 Gene Detail

Symbol

Plin1
Name

perilipin 1
Synonyms

6030432J05Rik, Peri, perilipin A, perilipin B, Plin

Feature Type

protein coding gene
IDs

MGI:1890505
NCBI Gene: 103968
Gene Overview

MyGene.info: PLIN1

Sequence Map

Chr7:79720218-79732903 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

12686 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 45.11 cM
Mapping Data

2 experiments

Human Ortholog

PLIN1, perilipin 1

Vertebrate Orthologs

9

Human Ortholog

PLIN1, perilipin 1
Orthology source: HomoloGene, HGNC
Synonyms

FPLD4, PERI, PLIN
Links

HGNC:9076

NCBI Gene ID: 5346

neXtProt AC: NX_O60240
Chr Location

15q26; chr15:89664365-89679417 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 2001
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish
HCOP

human homology predictions: PLIN1
Protein SuperFamily

lipid droplet-associated protein, perilipin type
Gene Tree

Plin1

Diseases

1 with human PLIN1 associations

				Human Disease	Mouse Models
				Lipodystrophy, Familial Partial, Type 4; FPLD4 OMIM: 613877

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

42 phenotypes from 5 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Radiation induced

2
Targeted

7
Transgenic

2
Genomic Mutations

3 involving Plin1
Incidental Mutations

Mutagenetix , APF

Homozygous inactivation of this gene leads to increased lean body mass and altered adipocyte lipolysis, leptin production and susceptibility to diet-induced obesity. Increased oxygen and food consumption, impaired cold adaptation, and altered glucose andblood homeostasis have also been observed.

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All GO Annotations

7
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

3
Tissues

3
cDNA Data

22
Literature Summary

9

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase plin1

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Plin1 interacts with 47 markers (Mir19a, Mir129-2, Mir182, ...) View All

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All Sequences

50
RefSeq

6
UniProt

5
CCDS

CCDS21385.1
UniGene

254917

			Length	Strain/Species	Flank
genomic	OTTMUSG00000058580	VEGA Gene Model \| MGI Sequence Detail	12686	C57BL/6J	± kb
transcript	OTTMUST00000143840	VEGA \| MGI Sequence Detail	2817	Not Applicable
polypeptide	OTTMUSP00000074978	VEGA \| MGI Sequence Detail	517	Not Applicable

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SNPs within 2kb

138 from dbSNP Build 142

RFLP

1

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UniProt

5 Sequences
Protein Ontology

PR:000012869 perilipin-1
InterPro Domains

IPR004279 Perilipin

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All nucleic 22

cDNA 22

Microarray probesets 2

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MGI:2444270

Summaries

All 58

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 27
Earliest

J:66267 Martinez-Botas J, et al., Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice. Nat Genet. 2000 Dec;26(4):474-9
Latest

J:232408 Van De Pette M, et al., Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome. PLoS Genet. 2016 Mar;12(3):e1005916

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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