Plin1
Gene Detail

Symbol Name ID

Plin1 perilipin 1 MGI:1890505

Synonyms

6030432J05Rik, Peri, perilipin A, perilipin B, Plin

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:79721164-79732776 bp, - strand From NCBI annotation of GRCm38   11613 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lipid droplet-associated protein, perilipin type
Gene Tree: Plin1

Human homologs

Human Homolog		PLIN1, perilipin 1
NCBI Gene ID		5346
neXtProt AC		NX_O60240
Human Synonyms		FPLD4, PERI, PLIN
Human Chr (Location)		15q26; chr15:89664367-89679417 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human PLIN1

Alleles and phenotypes

All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous inactivation of this gene leads to increased lean body mass and altered adipocyte lipolysis, leptin production and susceptibility to diet-induced obesity. Increased oxygen and food consumption, impaired cold adaptation, and altered glucose and blood homeostasis have also been observed.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	lipid catabolic process, lipid metabolic process
Component	cytosol, endoplasmic reticulum, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(22)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000030546 (Evidence)
Entrez Gene	103968 (Evidence)
UniGene	254917
DFCI	TC1586310, TC1611413, TC1615867, TC1638355
DoTS	DT.533984, DT.55252902, DT.91366491, DT.91418512
NIA Mouse Gene Index	U042825
Consensus CDS Project	CCDS21385.1
International Mouse Knockout Project Status	Plin1

Sequences

Length	Strain/Species
genomic	103968	NCBI Gene Model | MGI Sequence Detail	11613	C57BL/6J
transcript	NM_175640	RefSeq | MGI Sequence Detail	1935	C57BL/6
polypeptide	Q8CGN5	UniProt | EBI | MGI Sequence Detail	517	Not Applicable

All sequences(30) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(1) : SNPs within 2kb(128 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR004279	Perilipin
Protein Ontology	PR:000012869	perilipin-1

Graphical View of Protein Domain Structure

References

(Earliest) J:66267 Martinez-Botas J, et al., Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice. Nat Genet. 2000 Dec;26(4):474-9
(Latest) J:203690 Martinez-Lopez N, et al., Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep. 2013 Sep;14(9):795-803
All references(52)

Other accession IDs

MGI:2444270