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Plin1
Gene Detail
Symbol

Name
ID
Plin1
perilipin 1
MGI:1890505
Synonyms
6030432J05Rik, Peri, perilipin A, perilipin B, Plin
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:79721164-79732776 bp, - strand
From NCBI annotation of GRCm38

  11613 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: lipid droplet-associated protein, perilipin type
Gene Tree: Plin1

Human
homologs
Human Homolog PLIN1, perilipin 1
NCBI Gene ID 5346
neXtProt AC  NX_O60240
Human Synonyms  FPLD4, PERI, PLIN
Human Chr (Location)  15q26; chr15:89664367-89679417 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLIN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to increased lean body mass and altered adipocyte lipolysis, leptin production and susceptibility to diet-induced obesity. Increased oxygen and food consumption, impaired cold adaptation, and altered glucose and blood homeostasis have also been observed.
 
Interactions
Plin1 interacts with 47 markers (Mir19a, Mir129-2, Mir182, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process lipid catabolic process, lipid metabolic process
Component cytosol, endoplasmic reticulum, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000030546 (Evidence)
Entrez Gene103968 (Evidence)
UniGene254917
DFCITC1638355, TC1615867, TC1611413, TC1586310
DoTSDT.533984, DT.55252902, DT.91366491, DT.91418512
NIA Mouse Gene IndexU042825
Consensus CDS ProjectCCDS21385.1
International Mouse Knockout Project StatusPlin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 103968 NCBI Gene Model | MGI Sequence Detail 11613 C57BL/6J ±  kb
transcript NM_175640 RefSeq | MGI Sequence Detail 1935 C57BL/6 
polypeptide Q8CGN5 UniProt | EBI | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004279 Perilipin
Protein Ontology PR:000012869 perilipin-1
Graphical View of Protein Domain Structure
References
(Earliest) J:66267 Martinez-Botas J, et al., Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice. Nat Genet. 2000 Dec;26(4):474-9
(Latest) J:212396 Chen M, et al., PLIN1 deficiency affects testicular gene expression at the meiotic stage in the first wave of spermatogenesis. Gene. 2014 Jun 15;543(2):212-9
All references(54)
Other
accession IDs
MGI:2444270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory