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Laptm4b Gene Detail
Summary
  • Symbol
    Laptm4b
  • Name
    lysosomal-associated protein transmembrane 4B
  • Synonyms
    C330023P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890494
    NCBI Gene: 114128
  • Gene Overview
    MyGene.info: LAPTM4B
Location & Maps
more
  • Sequence Map
    Chr15:34238026-34284295 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46270 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LAPTM4B, lysosomal protein transmembrane 4 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LAPTM4B, lysosomal protein transmembrane 4 beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LAPTM4beta, LC27
  • Links
    NCBI Gene ID: 55353
    neXtProt AC: NX_Q86VI4

  • Chr Location
    8q22.1; chr8:97775581-97852602 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Laptm4b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 114128 NCBI Gene Model | MGI Sequence Detail 46270 C57BL/6J ±  kb
transcript NM_033521 RefSeq | MGI Sequence Detail 1897 C57BL/6  
polypeptide Q91XQ6 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    335 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000029588 lysosomal-associated transmembrane protein 4B
  • InterPro Domains
    IPR004687 Lysosomal-associated transmembrane protein 4/5
    IPR018401 Lysosomal-associated transmembrane protein 4B
Molecular
Reagents
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  • All nucleic 151
    cDNA 151

    Microarray probesets 5
Other
Accession IDs
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MGI:1915361
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory