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Il19 Gene Detail
Summary
  • Symbol
    Il19
  • Name
    interleukin 19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890472
    NCBI Gene: 329244
  • Gene Overview
    MyGene.info: IL19
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr1:130932656-130940115 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890472
protein coding gene Chr1:130932656-130945457 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016446
protein coding gene Chr1:134338431-134346210 (-)
A/J MGP_AJ_G0016429
protein coding gene Chr1:129370811-129378270 (-)
AKR/J MGP_AKRJ_G0016394
protein coding gene Chr1:133179327-133186776 (-)
BALB/cJ MGP_BALBcJ_G0016389
protein coding gene Chr1:129698608-129706032 (-)
C3H/HeJ MGP_C3HHeJ_G0016215
protein coding gene Chr1:133316714-133324183 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016850
protein coding gene Chr1:139336280-139343777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014564
protein coding gene Chr1:122510338-122517662 (-)
CAST/EiJ MGP_CASTEiJ_G0015795
protein coding gene Chr1:132308879-132316335 (-)
CBA/J MGP_CBAJ_G0016187
protein coding gene Chr1:144127999-144135419 (-)
DBA/2J MGP_DBA2J_G0016294
protein coding gene Chr1:128332951-128340396 (-)
FVB/NJ MGP_FVBNJ_G0016293
protein coding gene Chr1:126975978-126983386 (-)
LP/J MGP_LPJ_G0016365
protein coding gene Chr1:135651838-135659232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016318
protein coding gene Chr1:149903950-149911358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016886
protein coding gene Chr1:132943392-132950812 (-)
PWK/PhJ MGP_PWKPhJ_G0015581
protein coding gene Chr1:127303189-127311154 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015368
protein coding gene Chr1:131878647-131886105 (-)
WSB/EiJ MGP_WSBEiJ_G0015857
protein coding gene Chr1:132932536-132941214 (-)



Homology
more
  • Human Ortholog
    IL19, interleukin 19
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL19, interleukin 19
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-10C, MDA1, NG.1, ZMDA1
  • Links
    NCBI Gene ID: 29949
    neXtProt AC: NX_Q9UHD0
    UniProt: Q9UHD0

  • Chr Location
    1q32.1; chr1:206798870-206842981 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Il19
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit interleukin-23 (IL-23)-dependent epidermal hyperplasia. Mice homozygous for a different knock-out allele exhibit increased susceptibility to induced colitis with reduced B cell infiltration in chronic colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016524 Ensembl Gene Model | MGI Sequence Detail 7460 C57BL/6J ±  kb
transcript ENSMUST00000016668 Ensembl | MGI Sequence Detail 1021 Not Applicable  
polypeptide ENSMUSP00000016668 Ensembl | MGI Sequence Detail 176 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 36
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:253727 Gabunia K, et al., Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC. J Mol Cell Cardiol. 2017 Apr;105:38-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory