Pcbp3 MGI Mouse Gene Detail - MGI:1890470 - poly(rC) binding protein 3

Symbol

Pcbp3
Name

poly(rC) binding protein 3
Synonyms

AlphaCP-3

Feature Type

protein coding gene
IDs

MGI:1890470
NCBI Gene: 59093
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:76597691-76797721 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband B5.1-B5.3
Mapping Data

2 experiments

SNPs within 2kb

4403 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890470	protein coding gene	Chr10:76597688-76797951 (-)
129S1/SvImJ	ENSMUSG00200041710	protein coding gene	Chr10:73275200-73339331 (-)
A/J	ENSMUSG00195045525	protein coding gene	Chr10:73611806-73675946 (-)
AKR/J	ENSMUSG00220044284	protein coding gene	Chr10:73271511-73335652 (-)
BALB/cJ	ENSMUSG00180046099	protein coding gene	Chr10:73626267-73690399 (-)
C3H/HeJ	ENSMUSG00175042270	protein coding gene	Chr10:73497509-73561646 (-)
C57BL/6NJ	ENSMUSG00215051593	protein coding gene	Chr10:73235176-73299314 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015475	protein coding gene	Chr10:70799072-70995275 (-)
CAST/EiJ	ENSTCUG00005047645	protein coding gene	Chr10:73126075-73190295 (-)
CBA/J	ENSMUSG00210046601	protein coding gene	Chr10:73353715-73417846 (-)
DBA/2J	ENSMUSG00185048575	protein coding gene	Chr10:73696009-73760140 (-)
FVB/NJ	ENSMUSG00205041714	protein coding gene	Chr10:73387944-73452076 (-)
JF1/MsJ	ENSUMUG00000050952	protein coding gene	Chr10:74850861-74915034 (-)
LP/J	ENSMUSG00230050069	protein coding gene	Chr10:75465553-75529686 (-)
NOD/ShiLtJ	ENSMUSG00190050998	protein coding gene	Chr10:73673482-73737615 (-)
NZO/HlLtJ	ENSMUSG00225047290	protein coding gene	Chr10:79762208-79826339 (-)
PWK/PhJ	ENSLUMG00010046362	protein coding gene	Chr10:73239047-73303141 (-)
SPRET/EiJ	ENSMSPG00010045880	protein coding gene	Chr10:75044191-75108148 (-)
WSB/EiJ	ENSIUOG00005045718	protein coding gene	Chr10:73282314-73346560 (-)

Human Ortholog

PCBP3, poly(rC) binding protein 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCBP3, poly(rC) binding protein 3
Synonyms

ALPHA-CP3, PCBP3OT, PCBP3-OT1
Links

HGNC:8651

NCBI Gene ID: 54039

UniProt: P57721
Chr Location

21q22.3; chr21:45643694-45942454 (+) GRCh38

MGI Vertebrate Homology

Pcbp3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PCBP3
Gene Tree

Pcbp3

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References

2 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

10
Targeted

5
Genomic Mutations

5 involving Pcbp3
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1019
Tissues

201
cDNA Data

61
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pcbp2

ZFIN pcbp3

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All Sequences

150
RefSeq

100
UniProt

4
CCDS

CCDS35946.2, CCDS83716.1

Ensembl

ENSMUSG00000001120 (Evidence)
NCBI Gene

59093

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001120	Ensembl Gene Model \| MGI Sequence Detail	200031	C57BL/6J	± kb
transcript	ENSMUST00000001148	Ensembl \| MGI Sequence Detail	2013	Not Applicable
polypeptide	ENSMUSP00000001148	Ensembl \| MGI Sequence Detail	371	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012337 poly(rC)-binding protein 3

(term hierarchy)
InterPro Domains

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily
GlyGen

P57722 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 66

cDNA 63

Primer pair 2

Other 1

Microarray probesets 5

Summaries

All 77

Developmental Gene Expression 7

Diseases 2

Gene Ontology 5

Phenotypes 45
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Pcbp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98213	Chr10:76797702-76797778 (-)	-19 bp
Tssr98212	Chr10:76785145-76785150 (-)	12,573 bp
Tssr98211	Chr10:76720296-76720300 (-)	77,423 bp
Tssr98210	Chr10:76710314-76710332 (-)	87,398 bp
Tssr98209	Chr10:76658652-76658665 (-)	139,062 bp
Tssr98208	Chr10:76652551-76652568 (-)	145,161 bp
Tssr3257	Chr10:76634686-76634699 (-)	163,028 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29