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Vps35
Gene Detail
Symbol

Name
ID
Vps35
vacuolar protein sorting 35
MGI:1890467
Synonyms
Mem3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:85260392-85299497 bp, - strand
From NCBI annotation of GRCm38

  39106 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: VPS35
Protein SuperFamily: retromer complex, Vps35 subunit
Gene Tree: Vps35

Human
homologs
VPS35, VPS35 retromer complex component
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55737
neXtProt AC: NX_Q96QK1

Human Synonyms: MEM3, PARK17

Human Chr (Location): 16q12; chr16:46657995-46689232 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VPS35

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele die prior to E10.
 
Interactions
Vps35 interacts with 252 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process intracellular protein transport, negative regulation of late endosome to lysosome transport, ...
Component cytoplasm, cytosol, ...
Function protein binding, protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (67)    Tissues (54)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 6
RT-PCR 61
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vps35    NEW 
Molecular
reagents
All nucleic(23) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031696 (Evidence)
Entrez Gene 65114 (Evidence)
DFCI TC1573919, TC1596291
NIA Mouse Gene Index U030053
Consensus CDS Project CCDS40421.1
International Mouse Phenotyping Consortium Status Vps35
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 65114 NCBI Gene Model | MGI Sequence Detail 39106 C57BL/6J ±  kb
transcript NM_022997 RefSeq | MGI Sequence Detail 3169 C57BL/6 
polypeptide Q9EQH3 UniProt | EBI | MGI Sequence Detail 796 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(6)
Polymorphisms
PCR(1) : SNPs within 2kb(381 from dbSNP Build 137)    SNPs within 2kb including multiple locations(385)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR005378 Vacuolar protein sorting-associated protein 35
Protein Ontology PR:000017333 vacuolar protein sorting-associated protein 35
Graphical View of Protein Domain Structure
References
(Earliest) J:34783 Hwang S, et al., Genetic mapping and embryonic expression of a novel, maternally transcribed gene Mem3. Mamm Genome. 1996 Aug;7(8):586-90
(Latest) J:215242 Zhou GL, et al., Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption. J Cell Sci. 2014 Sep 15;127(Pt 18):3916-27
All references(40)
Other
accession IDs
MGD-MRK-35082, MGI:106625, MGI:2142604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory