Vps35
Gene Detail

Symbol Name ID

Vps35 vacuolar protein sorting 35 MGI:1890467

Synonyms

Mem3

Feature Type

protein coding gene

Genetic Map

Chromosome 8

41.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:85260392-85299497 bp, - strand From NCBI annotation of GRCm38   39106 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: retromer complex, Vps35 subunit
Gene Tree: Vps35

Human homologs

Human Homolog		VPS35, vacuolar protein sorting 35 homolog (S. cerevisiae)
NCBI Gene ID		55737
neXtProt AC		NX_Q96QK1
Human Synonyms		MEM3, PARK17
Human Chr (Location)		16q12; chr16:46693589-46723144 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human VPS35

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

Mice homozygous for a gene trap allele die prior to E10.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	protein transport, transport, ...
Component	cytoplasm, cytosol, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (72)    Tissues (57)    Images (1)
Theiler Stages: 1, 2, 3, 4, 9, 11, 15, 20, 23, 28

Assay Type	Results
Northern blot	8
RT-PCR	64

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000031696 (Evidence)
Entrez Gene	65114 (Evidence)
DFCI	TC1573919, TC1596291
NIA Mouse Gene Index	U030053
Consensus CDS Project	CCDS40421.1
International Mouse Knockout Project Status	Vps35

Sequences

Length	Strain/Species
genomic	65114	NCBI Gene Model | MGI Sequence Detail	39106	C57BL/6J
transcript	NM_022997	RefSeq | MGI Sequence Detail	3169	C57BL/6
polypeptide	Q9EQH3	UniProt | EBI | MGI Sequence Detail	796	Not Applicable

All sequences(44) RefSeq(2) UniProt(6)

Polymorphisms

PCR(1) : SNPs(276 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005378	Vacuolar protein sorting-associated protein 35
Protein Ontology	PR:000017333	vacuolar protein sorting-associated protein 35

Graphical View of Protein Domain Structure

References

(Earliest) J:34783 Hwang S, et al., Genetic mapping and embryonic expression of a novel, maternally transcribed gene Mem3. Mamm Genome. 1996 Aug;7(8):586-90
(Latest) J:192876 Wang CL, et al., VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1. Biol Open. 2013;1:1248-1257
All references(33)

Other accession IDs

MGD-MRK-35082, MGI:106625, MGI:2142604