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Dxo Gene Detail
Summary
  • Symbol
    Dxo
  • Name
    decapping exoribonuclease
  • Synonyms
    Dom3z
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890444
    NCBI Gene: 112403
  • Gene Overview
    MyGene.info: DXO
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34837019-34839187 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890444
protein coding gene Chr17:34837019-34839233 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023590
protein coding gene Chr17:34948845-34951050 (+)
A/J MGP_AJ_G0023552
protein coding gene Chr17:33807306-33809489 (+)
AKR/J MGP_AKRJ_G0023518
protein coding gene Chr17:34266097-34268290 (+)
BALB/cJ MGP_BALBcJ_G0023557
protein coding gene Chr17:33937619-33939801 (+)
C3H/HeJ MGP_C3HHeJ_G0023317
protein coding gene Chr17:34664283-34667661 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023997
protein coding gene Chr17:36285004-36288360 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021476
protein coding gene Chr17:31571780-31574001 (+)
CAST/EiJ MGP_CASTEiJ_G0022815
protein coding gene Chr17:34661202-34663400 (+)
CBA/J MGP_CBAJ_G0023295
protein coding gene Chr17:37797725-37799909 (+)
DBA/2J MGP_DBA2J_G0023423
protein coding gene Chr17:33121428-33123616 (+)
FVB/NJ MGP_FVBNJ_G0023390
protein coding gene Chr17:32951746-32953935 (+)
LP/J MGP_LPJ_G0023500
protein coding gene Chr17:35258923-35261906 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023413
protein coding gene Chr17:36726452-36728729 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024039
protein coding gene Chr17:34494229-34497400 (+)
PWK/PhJ MGP_PWKPhJ_G0022564
protein coding gene Chr17:31950766-31953308 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022381
protein coding gene Chr17:32497115-32499299 (+)
WSB/EiJ MGP_WSBEiJ_G0022877
protein coding gene Chr17:34603546-34607004 (+)



Homology
more
  • Human Ortholog
    DXO, decapping exoribonuclease
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DXO, decapping exoribonuclease
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DOM3L, DOM3Z, NG6, RAI1
  • Links
    NCBI Gene ID: 1797
    neXtProt AC: NX_O77932
    UniProt: O77932

  • Chr Location
    6p21.33; chr6:31969811-31972290 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38061
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DXO
  • Gene Tree
    Dxo
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 112403 NCBI Gene Model | MGI Sequence Detail 2169 C57BL/6J ±  kb
transcript NM_033613 RefSeq | MGI Sequence Detail 1472 C57BL/6  
polypeptide O70348 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    Genomic 1
    cDNA 41

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:63110 Martin AM, et al., Immunol Today. 2000;21(7):Centerfold
  • Latest
    J:196446 Jiao X, et al., A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol Cell. 2013 Apr 11;50(1):104-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory