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Uchl4 Gene Detail
Summary
  • Symbol
    Uchl4
  • Name
    ubiquitin carboxyl-terminal esterase L4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890440
    NCBI Gene: 93841
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:64142483-64143644 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 34.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890440
 protein coding gene Chr9:64142483-64143644 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034939
 protein coding gene Chr9:63891101-63893540 (+)
A/J MGP_AJ_G0034919
 protein coding gene Chr9:61754156-61755317 (+)
AKR/J MGP_AKRJ_G0034849
 protein coding gene Chr9:63186914-63189107 (+)
BALB/cJ MGP_BALBcJ_G0034912
 protein coding gene Chr9:61476526-61478663 (+)
C3H/HeJ MGP_C3HHeJ_G0034622
 protein coding gene Chr9:63717160-63718684 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035431
 protein coding gene Chr9:65623922-65625083 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032342
 protein coding gene Chr9:61400936-61402245 (+)
CAST/EiJ MGP_CASTEiJ_G0033943
 protein coding gene Chr9:63876704-63878991 (+)
CBA/J MGP_CBAJ_G0034593
 protein coding gene Chr9:67882903-67884064 (+)
DBA/2J MGP_DBA2J_G0034752
 protein coding gene Chr9:61533325-61534971 (+)
FVB/NJ MGP_FVBNJ_G0034694
 protein coding gene Chr9:60837258-60838419 (+)
LP/J MGP_LPJ_G0034835
 protein coding gene Chr9:64173369-64174530 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0035453
 protein coding gene Chr9:63294967-63296267 (+)
PWK/PhJ MGP_PWKPhJ_G0033647
 protein coding gene Chr9:61691274-61692427 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033481
 protein coding gene Chr9:63578703-63579869 (+)
WSB/EiJ MGP_WSBEiJ_G0034056
 protein coding gene Chr9:63194129-63196590 (+)



Homology
more
  • Human Ortholog
    UCHL3, ubiquitin C-terminal hydrolase L3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCHL3, ubiquitin C-terminal hydrolase L3
  • Synonyms
    UCH-L3
  • Links
    NCBI Gene ID: 7347
    neXtProt AC: NX_P15374
    UniProt: P15374

  • Chr Location
    13q22.2; chr13:75549483-75606020 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    23
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93841 NCBI Gene Model | MGI Sequence Detail 1162 C57BL/6J ±  kb
    transcript NM_033607 RefSeq | MGI Sequence Detail 1162 ZRU/MplStud  
    polypeptide P58321 UniProt | EBI | MGI Sequence Detail 233 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017221 ubiquitin carboxyl-terminal hydrolase isozyme L4
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase
      IPR036959 Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 22
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:69453 Osawa Y, et al., Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3. Biochem Biophys Res Commun. 2001 May 11;283(3):627-33
    • Latest
      J:261678 Aoidi R, et al., Mek1(Y130C) mice recapitulate aspects of human cardio-facio-cutaneous syndrome. Dis Model Mech. 2018 Mar 13;11(3):dmm031278
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory