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Suv39h2 Gene Detail
Summary
  • Symbol
    Suv39h2
  • Name
    suppressor of variegation 3-9 2
  • Synonyms
    4930507K23Rik, D2Ertd544e, KMT1B, Suv39h histone methyltransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890396
    NCBI Gene: 64707
  • Gene Overview
    MyGene.info: SUV39H2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:3455815-3474986 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 1.95 cM, cytoband A
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890396
protein coding gene Chr2:3455815-3475031 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025309
protein coding gene Chr2:437206-457222 (-)
A/J MGP_AJ_G0025285
protein coding gene Chr2:409255-428471 (-)
AKR/J MGP_AKRJ_G0025254
protein coding gene Chr2:418528-437744 (-)
BALB/cJ MGP_BALBcJ_G0025281
protein coding gene Chr2:398606-417822 (-)
C3H/HeJ MGP_C3HHeJ_G0025041
protein coding gene Chr2:429790-449006 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025724
protein coding gene Chr2:424691-444602 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023138
protein coding gene Chr2:354459-374061 (-)
CAST/EiJ MGP_CASTEiJ_G0024505
protein coding gene Chr2:433246-452247 (-)
CBA/J MGP_CBAJ_G0025021
protein coding gene Chr2:453194-472914 (-)
DBA/2J MGP_DBA2J_G0025152
protein coding gene Chr2:392191-411372 (-)
FVB/NJ MGP_FVBNJ_G0025114
protein coding gene Chr2:402737-423802 (-)
LP/J MGP_LPJ_G0025239
protein coding gene Chr2:430674-449974 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025147
protein coding gene Chr2:428093-447306 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025782
protein coding gene Chr2:417342-438196 (-)
PWK/PhJ MGP_PWKPhJ_G0024254
protein coding gene Chr2:392538-411909 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024056
protein coding gene Chr2:444581-466803 (-)
WSB/EiJ MGP_WSBEiJ_G0024575
protein coding gene Chr2:424369-443585 (-)



Homology
more
  • Human Ortholog
    SUV39H2, suppressor of variegation 3-9 homolog 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SUV39H2, suppressor of variegation 3-9 homolog 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KMT1B
  • Links
    NCBI Gene ID: 79723
    neXtProt AC: NX_Q9H5I1
    UniProt: Q9H5I1

  • Chr Location
    10p13; chr10:14878783-14904315 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Less than 5% of mice either heterozygous or homozygous for a reporter/null allele develop late-onset B cell lymphomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 64707 NCBI Gene Model | MGI Sequence Detail 19172 C57BL/6J ±  kb
transcript NM_022724 RefSeq | MGI Sequence Detail 4282 Not Specified  
polypeptide Q9EQQ0 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 1
    cDNA 18
    Primer pair 5
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1261878, MGI:1922296, MGI:2138788
References
more
  • Summaries
    All 56
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:255491 Matsuura T, et al., Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin. Sci Rep. 2017 Sep 29;7(1):12462

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory