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Zfp277 Gene Detail
Summary
  • Symbol
    Zfp277
  • Name
    zinc finger protein 277
  • Synonyms
    2410017E24Rik, NIRF4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890393
    NCBI Gene: 246196
  • Gene Overview
    MyGene.info: ZNF277
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:40315046-40445790 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 18.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1000 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890393
protein coding gene Chr12:40315046-40445902 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019704
protein coding gene Chr12:38735602-38862836 (-)
A/J MGP_AJ_G0019670
protein coding gene Chr12:37461392-37587352 (-)
AKR/J MGP_AKRJ_G0019641
protein coding gene Chr12:38600675-38729364 (-)
BALB/cJ MGP_BALBcJ_G0019648
protein coding gene Chr12:37677501-37799948 (-)
C3H/HeJ MGP_C3HHeJ_G0019452
protein coding gene Chr12:38531932-38657325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020095
protein coding gene Chr12:39899816-40021596 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017720
protein coding gene Chr12:36589407-36706926 (-)
CAST/EiJ MGP_CASTEiJ_G0019005
protein coding gene Chr12:33716771-33834263 (-)
CBA/J MGP_CBAJ_G0019424
protein coding gene Chr12:41258357-41384588 (-)
DBA/2J MGP_DBA2J_G0019537
protein coding gene Chr12:37321832-37437975 (-)
FVB/NJ MGP_FVBNJ_G0019526
protein coding gene Chr12:36951580-37067509 (-)
LP/J MGP_LPJ_G0019607
protein coding gene Chr12:38734164-38859962 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019562
protein coding gene Chr12:41410926-41531307 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020135
protein coding gene Chr12:38162006-38288923 (-)
PWK/PhJ MGP_PWKPhJ_G0018772
protein coding gene Chr12:31997509-32112741 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018562
protein coding gene Chr12:32819859-32946246 (-)
WSB/EiJ MGP_WSBEiJ_G0019055
protein coding gene Chr12:38464491-38591987 (-)



Homology
more
  • Human Ortholog
    ZNF277, zinc finger protein 277
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZNF277, zinc finger protein 277
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NRIF4, ZNF277P
  • Links
    NCBI Gene ID: 11179
    neXtProt AC: NX_Q9NRM2
    UniProt: Q9NRM2

  • Chr Location
    7q31.1; chr7:112206588-112343934 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11087
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZNF277
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early cellular preplicative senescence in MEFs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 246196 NCBI Gene Model | MGI Sequence Detail 130745 C57BL/6J ±  kb
transcript NM_172575 RefSeq | MGI Sequence Detail 2454 C57BL/6  
polypeptide NP_766163 RefSeq | MGI Sequence Detail 583 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR036236 Zinc finger C2H2 superfamily
    IPR013087 Zinc finger C2H2-type
Molecular
Reagents
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  • All nucleic 54
    cDNA 53
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1922071
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:76447 Liang H, et al., Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277. Genomics. 2000 Jun 1;66(2):226-8
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory