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Fstl3 Gene Detail
Summary
  • Symbol
    Fstl3
  • Name
    follistatin-like 3
  • Synonyms
    E030038F23Rik, Flrg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890391
    NCBI Gene: 83554
  • Gene Overview
    MyGene.info: FSTL3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79777274-79782630 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890391
protein coding gene Chr10:79777272-79782630 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017459
protein coding gene Chr10:80320960-80326324 (+)
A/J MGP_AJ_G0017437
protein coding gene Chr10:77530639-77536009 (+)
AKR/J MGP_AKRJ_G0017398
protein coding gene Chr10:79638113-79643478 (+)
BALB/cJ MGP_BALBcJ_G0017399
protein coding gene Chr10:77756812-77762166 (+)
C3H/HeJ MGP_C3HHeJ_G0017222
protein coding gene Chr10:79747114-79752468 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017853
protein coding gene Chr10:83095071-83101542 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015541
protein coding gene Chr10:73755910-73761725 (+)
CAST/EiJ MGP_CASTEiJ_G0016789
protein coding gene Chr10:79919995-79925359 (+)
CBA/J MGP_CBAJ_G0017194
protein coding gene Chr10:86321081-86326451 (+)
DBA/2J MGP_DBA2J_G0017300
protein coding gene Chr10:76745691-76751070 (+)
FVB/NJ MGP_FVBNJ_G0017294
protein coding gene Chr10:75917043-75922402 (+)
LP/J MGP_LPJ_G0017371
protein coding gene Chr10:80804702-80810064 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017320
protein coding gene Chr10:88302754-88308108 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017894
protein coding gene Chr10:79617480-79622861 (+)
PWK/PhJ MGP_PWKPhJ_G0016570
protein coding gene Chr10:76604775-76610173 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016359
protein coding gene Chr10:78595700-78601038 (+)
WSB/EiJ MGP_WSBEiJ_G0016849
protein coding gene Chr10:79647637-79652790 (+)



Homology
more
  • Human Ortholog
    FSTL3, follistatin like 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FSTL3, follistatin like 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FLRG, FSRP
  • Links
    NCBI Gene ID: 10272
    neXtProt AC: NX_O95633
    UniProt: O95633

  • Chr Location
    19p13.3; chr19:676389-683392 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4280
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FSTL3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Adult mice homozygous for a knock-out allele display increased pancreatic islet number and size, beta cell hyperplasia, hepatic steatosis, increased heart weight, mild hypertension, and alterations in glucose homeostasis and fat distribution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83554 NCBI Gene Model | MGI Sequence Detail 5357 C57BL/6J ±  kb
    transcript NM_031380 RefSeq | MGI Sequence Detail 1953 C57BL/6  
    polypeptide Q9EQC7 UniProt | EBI | MGI Sequence Detail 256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 45

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443015
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:238260 Liu TY, et al., Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Open Biol. 2017 Jan;7(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory