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Fstl3 Gene Detail
Summary
  • Symbol
    Fstl3
  • Name
    follistatin-like 3
  • Synonyms
    E030038F23Rik, Flrg
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890391
    NCBI Gene: 83554
  • Gene Overview
    MyGene.info: FSTL3
Location & Maps
more
  • Sequence Map
    Chr10:79777272-79782630 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5359 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FSTL3, follistatin like 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FSTL3, follistatin like 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FLRG, FSRP
  • Links
    NCBI Gene ID: 10272
    neXtProt AC: NX_O95633

  • Chr Location
    19p13; chr19:676389-683392 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4280
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FSTL3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Fstl3
  • Incidental Mutations
Adult mice homozygous for a knock-out allele display increased pancreatic islet number and size, beta cell hyperplasia, hepatic steatosis, increased heart weight, mild hypertension, and alterations in glucose homeostasis and fat distribution.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035143 VEGA Gene Model | MGI Sequence Detail 5359 C57BL/6J ±  kb
transcript OTTMUST00000089489 VEGA | MGI Sequence Detail 1955 Not Applicable  
polypeptide OTTMUSP00000048913 VEGA | MGI Sequence Detail 256 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 44

    Microarray probesets 4
Other
Accession IDs
less
MGI:2443015
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:66713 Tsuchida K, et al., Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family. J Biol Chem. 2000 Dec 29;275(52):40788-96
  • Latest
    J:233840 Brown ML, et al., Activin Enhances alpha- to beta-Cell Transdifferentiation as a Source For beta-Cells In Male FSTL3 Knockout Mice. Endocrinology. 2016 Mar;157(3):1043-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory