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Fstl3
Gene Detail
Symbol

Name
ID
Fstl3
follistatin-like 3
MGI:1890391
Synonyms
E030038F23Rik, Flrg
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:79777272-79782630 bp, + strand
From VEGA annotation of GRCm38

  5359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4280  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fstl3

Human
homologs
Human Homolog FSTL3, follistatin-like 3 (secreted glycoprotein)
NCBI Gene ID 10272
neXtProt AC  NX_O95633
Human Synonyms  FLRG, FSRP
Human Chr (Location)  19p13; chr19:676389-683392 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Adult mice homozygous for a knock-out allele display increased pancreatic islet number and size, beta cell hyperplasia, hepatic steatosis, increased heart weight, mild hypertension, and alterations in glucose homeostasis and fat distribution.
 
Phenotype Images(2)
Interactions
Fstl3 interacts with 112 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(44)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035143 (Evidence)
Ensembl Gene ModelENSMUSG00000020325 (Evidence)
Entrez Gene83554 (Evidence)
UniGene251710
DFCITC1579750, TC1611593
NIA Mouse Gene IndexU011723
Consensus CDS ProjectCCDS23990.1
International Mouse Knockout Project StatusFstl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035143 VEGA Gene Model | MGI Sequence Detail 5359 C57BL/6J ±  kb
transcript OTTMUST00000089489 VEGA | MGI Sequence Detail 1955 Not Applicable 
polypeptide OTTMUSP00000048913 VEGA | MGI Sequence Detail 256 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR015369 Follistatin/Osteonectin EGF domain
InterPro IPR002350 Kazal domain
InterPro IPR017878 TB domain
Protein Ontology PR:000007686 follistatin-related protein 3
References
(Earliest) J:66713 Tsuchida K, et al., Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family. J Biol Chem. 2000 Dec 29;275(52):40788-96
(Latest) J:201148 Lee YS, et al., Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22
All references(41)
Other
accession IDs
MGI:2443015

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory