Fstl3 MGI Mouse Gene Detail - MGI:1890391

Symbol

Fstl3
Name

follistatin-like 3
Synonyms

E030038F23Rik, Flrg

Feature Type

protein coding gene
IDs

MGI:1890391
NCBI Gene: 83554
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:79613108-79618464 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

163 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890391	protein coding gene	Chr10:79613106-79618464 (+)
129S1/SvImJ	ENSMUSG00200048979	protein coding gene	Chr10:76236787-76242144 (+)
A/J	ENSMUSG00195038086	protein coding gene	Chr10:76632310-76637671 (+)
AKR/J	ENSMUSG00220042606	protein coding gene	Chr10:76229878-76235238 (+)
BALB/cJ	ENSMUSG00180044255	protein coding gene	Chr10:76642795-76648156 (+)
C3H/HeJ	ENSMUSG00175051872	protein coding gene	Chr10:76513483-76518843 (+)
C57BL/6NJ	ENSMUSG00215049386	protein coding gene	Chr10:76255167-76260528 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015541	protein coding gene	Chr10:73755910-73761725 (+)
CAST/EiJ	ENSTCUG00005047112	protein coding gene	Chr10:76139777-76145132 (+)
CBA/J	ENSMUSG00210044428	protein coding gene	Chr10:76369567-76374926 (+)
DBA/2J	ENSMUSG00185045671	protein coding gene	Chr10:76711946-76717305 (+)
FVB/NJ	ENSMUSG00205045612	protein coding gene	Chr10:76424738-76430096 (+)
JF1/MsJ	ENSUMUG00000037662	protein coding gene	Chr10:77942177-77947527 (+)
LP/J	ENSMUSG00230050991	protein coding gene	Chr10:78481715-78487074 (+)
NOD/ShiLtJ	ENSMUSG00190046321	protein coding gene	Chr10:76625773-76631131 (+)
NZO/HlLtJ	ENSMUSG00225049671	protein coding gene	Chr10:82768062-82773421 (+)
PWK/PhJ	ENSLUMG00010036625	protein coding gene	Chr10:76301601-76306951 (+)
SPRET/EiJ	ENSMSPG00010036434	protein coding gene	Chr10:77921615-77926955 (+)
WSB/EiJ	ENSIUOG00005049512	protein coding gene	Chr10:76329352-76334708 (+)

Human Ortholog

FSTL3, follistatin like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FSTL3, follistatin like 3
Synonyms

FLRG, FSRP
Links

HGNC:3973

NCBI Gene ID: 10272

UniProt: O95633
Chr Location

19p13.3; chr19:676392-683392 (+) GRCh38

MGI Vertebrate Homology

Fstl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FSTL3
Gene Tree

Fstl3

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
2 images
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

7
Targeted

8
Genomic Mutations

1 involving Fstl3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Adult mice homozygous for a knock-out allele display increased pancreatic islet number and size, beta cell hyperplasia, hepatic steatosis, increased heart weight, mild hypertension, and alterations in glucose homeostasis and fat distribution.

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All GO Annotations

41
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

643
Tissues

29
cDNA Data

45
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FSTL3

Xenbase fstl3

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS23990.1

Ensembl

ENSMUSG00000020325 (Evidence)
NCBI Gene

83554

			Length	Strain/Species	Flank
genomic	83554	NCBI Gene Model \| MGI Sequence Detail	5357	C57BL/6J	± kb
transcript	NM_031380	RefSeq \| MGI Sequence Detail	1953	C57BL/6
polypeptide	Q9EQC7	UniProt \| EBI \| MGI Sequence Detail	256	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007686 follistatin-related protein 3

(term hierarchy)
InterPro Domains

IPR003645 Follistatin-like, N-terminal

IPR015369 Follistatin/Osteonectin EGF domain

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily

IPR050653 Protease Inhibitors and Growth Factor Antagonists

IPR017878 TB domain

IPR036773 TGF-beta binding (TB) domain superfamily
GlyGen

Q9EQC7 2 sites

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All nucleic 48

cDNA 45

Primer pair 3

Microarray probesets 4

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MGI:2443015

Summaries

All 66

Developmental Gene Expression 9

Gene Ontology 9

Phenotypes 24
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:370220 Kobayashi N, et al., Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance. Nat Commun. 2025 Apr 17;16(1):3678

TSS for Fstl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94388	Chr10:79613095-79613114 (+)	-3 bp
Tssr94389	Chr10:79613123-79613132 (+)	20 bp
Tssr94390	Chr10:79616806-79616818 (+)	3,704 bp
Tssr94391	Chr10:79616986-79616995 (+)	3,883 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29