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Igf2bp3 Gene Detail
Summary
  • Symbol
    Igf2bp3
  • Name
    insulin-like growth factor 2 mRNA binding protein 3
  • Synonyms
    2610101N11Rik, IMP3, Koc13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890359
    NCBI Gene: 140488
  • Gene Overview
    MyGene.info: IGF2BP3
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:49085223-49214957 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.82 cM, cytoband B2.3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    557 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890359
 protein coding gene Chr6:49085218-49215013 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030721
 protein coding gene Chr6:48070293-48213247 (-)
A/J MGP_AJ_G0030692
 protein coding gene Chr6:45878183-46011604 (-)
AKR/J MGP_AKRJ_G0030617
 protein coding gene Chr6:47494819-47634142 (-)
BALB/cJ MGP_BALBcJ_G0030702
 protein coding gene Chr6:46217099-46347773 (-)
C3H/HeJ MGP_C3HHeJ_G0030415
 protein coding gene Chr6:47498299-47641693 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031157
 protein coding gene Chr6:49203821-49345105 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028364
 protein coding gene Chr6:43490392-43620030 (-)
CAST/EiJ MGP_CASTEiJ_G0029819
 protein coding gene Chr6:47223496-47357984 (-)
CBA/J MGP_CBAJ_G0030390
 protein coding gene Chr6:51243895-51389552 (-)
DBA/2J MGP_DBA2J_G0030539
 protein coding gene Chr6:45790278-45924641 (-)
FVB/NJ MGP_FVBNJ_G0030491
 protein coding gene Chr6:45432698-45565947 (-)
LP/J MGP_LPJ_G0030624
 protein coding gene Chr6:48052335-48191470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030525
 protein coding gene Chr6:54008348-54154333 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031186
 protein coding gene Chr6:47359316-47496607 (-)
PWK/PhJ MGP_PWKPhJ_G0029531
 protein coding gene Chr6:45336791-45470964 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029367
 protein coding gene Chr6:46704949-46844717 (-)
WSB/EiJ MGP_WSBEiJ_G0029896
 protein coding gene Chr6:47359315-47495573 (-)



Homology
more
  • Human Ortholog
    IGF2BP3, insulin like growth factor 2 mRNA binding protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IGF2BP3, insulin like growth factor 2 mRNA binding protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT98, IMP3, IMP-3, KOC, KOC1, VICKZ3
  • Links
    NCBI Gene ID: 10643
    neXtProt AC: NX_O00425
    UniProt: O00425

  • Chr Location
    7p15.3; chr7:23310209-23470674 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    41
  • Tissues
    35
  • cDNA Data
    16
  • Literature Summary
    13
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029814 Ensembl Gene Model | MGI Sequence Detail 129735 C57BL/6J ±  kb
transcript ENSMUST00000031838 Ensembl | MGI Sequence Detail 4345 Not Applicable  
polypeptide ENSMUSP00000031838 Ensembl | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 3
    cDNA 18
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1919721, MGI:2141367, MGI:2141534, MGI:2141597
References
more
  • Summaries
    All 47
    Developmental Gene Expression 13
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:30335 Duh JL, et al., The Y-box motif mediates redox-dependent transcriptional activation in mouse cells. J Biol Chem. 1995 Dec 22;270(51):30499-507
  • Latest
    J:235757 Degrauwe N, et al., The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing. Cell Rep. 2016 May 24;15(8):1634-47
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/08/2019
MGI 6.14 		The Jackson Laboratory