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Fetub Gene Detail
Summary
  • Symbol
    Fetub
  • Name
    fetuin beta
  • Synonyms
    2310011O17Rik, D17980
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890221
    NCBI Gene: 59083
  • Gene Overview
    MyGene.info: FETUB
Location & Maps
more
  • Sequence Map
    Chr16:22918382-22939766 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21385 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.76 cM, cytoband B
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FETUB, fetuin B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FETUB, fetuin B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    16G2, Gugu, IRL685
  • Links
    NCBI Gene ID: 26998
    neXtProt AC: NX_Q9UGM5

  • Chr Location
    3q27; chr3:186635832-186653008 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8660
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FETUB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female infertility due to premature hardening of the zona pellucida.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022871 Ensembl Gene Model | MGI Sequence Detail 21385 C57BL/6J ±  kb
transcript ENSMUST00000167399 Ensembl | MGI Sequence Detail 1421 Not Applicable  
polypeptide ENSMUSP00000128745 Ensembl | MGI Sequence Detail 388 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    94 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007464 fetuin-B
  • InterPro Domains
    IPR000010 Cystatin domain
    IPR025764 Fetuin-B-type cystatin domain
    IPR001363 Proteinase inhibitor I25C, fetuin, conserved site
Molecular
Reagents
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  • All nucleic 82
    cDNA 82

    Microarray probesets 3
Other
Accession IDs
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MGI:1915165, MGI:2146393
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:64478 Olivier E, et al., Fetuin-B, a second member of the fetuin family in mammals. Biochem J. 2000 Sep 1;350 Pt 2:589-97
  • Latest
    J:196435 Dietzel E, et al., Fetuin-B, a liver-derived plasma protein is essential for fertilization. Dev Cell. 2013 Apr 15;25(1):106-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory