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Gpr132
Gene Detail
 Symbol
Name
ID
Gpr132
G protein-coupled receptor 132
MGI:1890220
Synonyms G2a, G2 accumulation
Feature Type protein coding gene
Genetic Map
Chromosome 12
61.25 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:112850876-112860916 bp, - strand
From NCBI annotation of GRCm38

  10041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: probable G protein-coupled receptor 132
Gene Tree: Gpr132

Human
homologs
Human Homolog GPR132, G protein-coupled receptor 132
NCBI Gene ID 29933
neXtProt AC  NX_Q9UNW8
Human Synonyms  G2A
Human Chr (Location)  14q32.3; chr14:105049389-105065550 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for disruptions in this gene display a generally normal phenotype but eventually develop a "late onset lymphoproliferative autoimmune syndrome"
 
Human Diseases Modeled Using Mouse Gpr132 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gpr132 interacts with 182 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process G1/S transition of mitotic cell cycle, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function G-protein coupled receptor activity, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (57)    Tissues (53)    Images (7)
Theiler Stages: 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 53
RT-PCR 4
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021298 (Evidence)
Entrez Gene56696 (Evidence)
UniGene20455
DFCITC1586494, TC1692607
DoTSDT.488990
NIA Mouse Gene IndexU034392
Consensus CDS ProjectCCDS26199.1
International Mouse Knockout Project StatusGpr132
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56696 NCBI Gene Model | MGI Sequence Detail 10041 C57BL/6J ±  kb
transcript NM_019925 RefSeq | MGI Sequence Detail 2439 C57BL/6 
polypeptide Q9Z282 UniProt | EBI | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005388 G2A lysophosphatidylcholine receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001504 G-protein coupled receptor 132
Graphical View of Protein Domain Structure
References (Earliest) J:64928 Weng Z, et al., A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12334-9
(Latest) J:208996 Palm NW, et al., Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity. 2013 Nov 14;39(5):976-85
All references(45)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory