Gpr132
Gene Detail

Symbol Name ID

Gpr132 G protein-coupled receptor 132 MGI:1890220

Synonyms

G2a, G2 accumulation

Feature Type

protein coding gene

Genetic Map

Chromosome 12

61.25 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:112850876-112860916 bp, - strand From NCBI annotation of GRCm38   10041 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: probable G protein-coupled receptor 132
Gene Tree: Gpr132

Human homologs

Human Homolog		GPR132, G protein-coupled receptor 132
NCBI Gene ID		29933
neXtProt AC		NX_Q9UNW8
Human Synonyms		G2A
Human Chr (Location)		14q32.3; chr14:105515737-105531754 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene display a generally normal phenotype but eventually develop a "late onset lymphoproliferative autoimmune syndrome"

 
Human Diseases Modeled Using Mouse Gpr132 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	G1/S transition of mitotic cell cycle, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (3)    Images (5)
Theiler Stages: 23, 24, 28

Assay Type	Results
RNA in situ	4
RT-PCR	4

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000021298 (Evidence)
Entrez Gene	56696 (Evidence)
UniGene	20455
DFCI	TC1586494, TC1692607
DoTS	DT.488990
NIA Mouse Gene Index	U034392
Consensus CDS Project	CCDS26199.1
International Mouse Knockout Project Status	Gpr132

Sequences

Length	Strain/Species
genomic	56696	NCBI Gene Model | MGI Sequence Detail	10041	C57BL/6J
transcript	NM_019925	RefSeq | MGI Sequence Detail	2439	C57BL/6
polypeptide	Q9Z282	UniProt | EBI | MGI Sequence Detail	382	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(97 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005388	G2A lysophosphatidylcholine receptor
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001504	G-protein coupled receptor 132

Graphical View of Protein Domain Structure

References

(Earliest) J:64928 Weng Z, et al., A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12334-9
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(41)