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Gpr132
Gene Detail
Symbol

Name
ID
Gpr132
G protein-coupled receptor 132
MGI:1890220
Synonyms
G2a, G2 accumulation
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.25 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:112850876-112860916 bp, - strand
From Ensembl annotation of GRCm38

  10041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8350  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: GPR132
Protein SuperFamily: probable G protein-coupled receptor 132
Gene Tree: Gpr132

Human
homologs
GPR132, G protein-coupled receptor 132
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29933
neXtProt AC: NX_Q9UNW8

Human Synonyms: G2A

Human Chr (Location): 14q32.3; chr14:105049389-105065550 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from CvDC )
 
Mice homozygous for disruptions in this gene display a generally normal phenotype but eventually develop a "late onset lymphoproliferative autoimmune syndrome"
 
Human Diseases Modeled in Mice Using Gpr132 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gpr132 interacts with 182 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (57)    Tissues (53)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
RT-PCR 4
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gpr132    NEW 
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021298 (Evidence)
Entrez Gene 56696 (Evidence)
UniGene 20455
DFCI TC1586494, TC1692607
DoTS DT.488990
NIA Mouse Gene Index U034392
Consensus CDS Project CCDS26199.1
International Mouse Phenotyping Consortium Status Gpr132
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021298 Ensembl Gene Model | MGI Sequence Detail 10041 C57BL/6J ±  kb
transcript ENSMUST00000021729 Ensembl | MGI Sequence Detail 2439 Not Applicable 
polypeptide ENSMUSP00000021729 Ensembl | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005388 G2A lysophosphatidylcholine receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001504 G-protein coupled receptor 132
References
(Earliest) J:64928 Weng Z, et al., A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12334-9
(Latest) J:221298 Wang Y, et al., Deletion of yes-associated protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circ Res. 2014 Mar 14;114(6):957-65
All references(45)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory