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Akap10 Gene Detail
Summary
  • Symbol
    Akap10
  • Name
    A kinase (PRKA) anchor protein 10
  • Synonyms
    1500031L16Rik, B130049N18Rik, D-AKAP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890218
    NCBI Gene: 56697
Location & Maps
more
  • Sequence Map
    Chr11:61871307-61930252 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58946 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AKAP10, A-kinase anchoring protein 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AKAP10, A-kinase anchoring protein 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AKAP-10, D-AKAP2, D-AKAP-2, PRKA10
  • Links
    NCBI Gene ID: 11216
    neXtProt AC: NX_O43572

  • Chr Location
    17p11.1; chr17:19904452-19977856 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human AKAP10 associations

Human Disease Mouse Models
       Cardiac Conduction Defect   OMIM: 115080
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Targeted
    2
  • Genomic Mutations
    1 involving Akap10
  • Incidental Mutations
Mice homozygous for a gene trapped allele display sinus arrhythmia, sinus pauses, and atrioventricular heart block indicating excessive vagus nerve sensitivity; about 50% of homozygous and 25% of heterozygous mutant mice die in the first year of life, and survival is sensitive to genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005847 VEGA Gene Model | MGI Sequence Detail 58946 C57BL/6J ±  kb
transcript OTTMUST00000013004 VEGA | MGI Sequence Detail 3874 Not Applicable  
polypeptide OTTMUSP00000006045 VEGA | MGI Sequence Detail 662 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    289 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003884 A-kinase anchor protein 10, mitochondrial
  • InterPro Domains
    IPR016137 RGS domain
Molecular
Reagents
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  • All nucleic 49
    cDNA 49

    Microarray probesets 4
Other
Accession IDs
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MGI:1916263, MGI:2442725
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:64927 Huang LJ, et al., D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11184-9
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory