About   Help   FAQ
Akap10
Gene Detail
 Symbol
Name
ID
Akap10
A kinase (PRKA) anchor protein 10
MGI:1890218
Synonyms 1500031L16Rik, B130049N18Rik, D-AKAP2
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:61871307-61930252 bp, - strand
From VEGA annotation of GRCm38

  58946 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32452  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Akap10

Human
homologs
Human Homolog AKAP10, A kinase (PRKA) anchor protein 10
NCBI Gene ID 11216
neXtProt AC  NX_O43572
Human Synonyms  AKAP-10, D-AKAP2, D-AKAP-2, PRKA10
Human Chr (Location)  17p11.1; chr17:19904452-19977856 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AKAP10
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(24) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele display sinus arrhythmia, sinus pauses, and atrioventricular heart block indicating excessive vagus nerve sensitivity; about 50% of homozygous and 25% of heterozygous mutant mice die in the first year of life, and survival is sensitive to genetic background.
 
Interactions
Akap10 interacts with 284 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process protein localization, regulation of G-protein coupled receptor protein signaling pathway, ...
Component cytoplasm, membrane, ...
Function protein kinase A binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (78)    Tissues (54)    Images (20)
Theiler Stages: 10, 18, 19, 23, 25, 28
Assay TypeResults
RNA in situ 66
Northern blot 12
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) cDNA(49)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005847 (Evidence)
Ensembl Gene ModelENSMUSG00000047804 (Evidence)
Entrez Gene56697 (Evidence)
UniGene274404
DFCITC1578547, TC1610210, TC1612417
DoTSDT.101158941, DT.101369977, DT.40141397, DT.55266643, DT.91570199
NIA Mouse Gene IndexU032897
Consensus CDS ProjectCCDS24821.1
International Mouse Knockout Project StatusAkap10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005847 VEGA Gene Model | MGI Sequence Detail 58946 C57BL/6J ±  kb
transcript OTTMUST00000013004 VEGA | MGI Sequence Detail 3874 Not Applicable 
polypeptide OTTMUSP00000006045 VEGA | MGI Sequence Detail 662 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(289 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000003884 A-kinase anchor protein 10, mitochondrial
References (Earliest) J:64927 Huang LJ, et al., D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11184-9
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(44)
Other
accession IDs
MGI:1916263, MGI:2442725

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory