Akap10
Gene Detail

Symbol Name ID

Akap10 A kinase (PRKA) anchor protein 10 MGI:1890218

Synonyms

1500031L16Rik, B130049N18Rik, D-AKAP2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:61871307-61930252 bp, - strand From VEGA annotation of GRCm38   58946 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32452  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Akap10

Human homologs

Human Homolog		AKAP10, A kinase (PRKA) anchor protein 10
NCBI Gene ID		11216
neXtProt AC		NX_O43572
Human Synonyms		AKAP-10, D-AKAP2, D-AKAP-2, PRKA10
Human Chr (Location)		17p11.1; chr17:19807765-19881169 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AKAP10

Alleles and phenotypes

All alleles(25) : Targeted(1) Gene trapped(24)
 

Mice homozygous for a gene trapped allele display sinus arrhythmia, sinus pauses, and atrioventricular heart block indicating excessive vagus nerve sensitivity; about 50% of homozygous and 25% of heterozygous mutant mice die in the first year of life, and survival is sensitive to genetic background.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	protein localization, termination of G-protein coupled receptor signaling pathway
Component	cytoplasm, membrane, ...
Function	protein kinase A binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (78)    Tissues (54)    Images (20)
Theiler Stages: 10, 18, 19, 23, 25, 28

Assay Type	Results
RNA in situ	66
Northern blot	12

cDNA source data(50)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(54) cDNA(54)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005847 (Evidence)
Ensembl Gene Model	ENSMUSG00000047804 (Evidence)
Entrez Gene	56697 (Evidence)
UniGene	274404
DFCI	TC1578547, TC1610210, TC1612417
DoTS	DT.101158941, DT.101369977, DT.40141397, DT.55266643, DT.91570199
NIA Mouse Gene Index	U032897
Consensus CDS Project	CCDS24821.1
International Mouse Knockout Project Status	Akap10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005847	VEGA Gene Model | MGI Sequence Detail	58946	C57BL/6J
transcript	OTTMUST00000013004	VEGA | MGI Sequence Detail	3874	Not Applicable
polypeptide	OTTMUSP00000006045	VEGA | MGI Sequence Detail	662	Not Applicable

All sequences(43) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(170 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000003884	A-kinase anchor protein 10, mitochondrial

References

(Earliest) J:64927 Huang LJ, et al., D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11184-9
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(42)

Other accession IDs

MGI:1916263, MGI:2442725