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Stx8 Gene Detail
Summary
  • Symbol
    Stx8
  • Name
    syntaxin 8
  • Synonyms
    0610007H08Rik, 1110002H11Rik, 4930571E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890156
    NCBI Gene: 55943
  • Gene Overview
    MyGene.info: STX8
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:67966411-68207148 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 41.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890156
protein coding gene Chr11:67966193-68207148 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018498
protein coding gene Chr11:68289242-68544641 (+)
A/J MGP_AJ_G0018467
protein coding gene Chr11:65735504-65981386 (+)
AKR/J MGP_AKRJ_G0018436
protein coding gene Chr11:67696544-67947801 (+)
BALB/cJ MGP_BALBcJ_G0018438
protein coding gene Chr11:66022238-66269239 (+)
C3H/HeJ MGP_C3HHeJ_G0018251
protein coding gene Chr11:67720754-67971902 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018890
protein coding gene Chr11:70373667-70639885 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016534
protein coding gene Chr11:62686817-62924063 (+)
CAST/EiJ MGP_CASTEiJ_G0017807
protein coding gene Chr11:67934231-68189035 (+)
CBA/J MGP_CBAJ_G0018225
protein coding gene Chr11:73495496-73771459 (+)
DBA/2J MGP_DBA2J_G0018334
protein coding gene Chr11:65341315-65582850 (+)
FVB/NJ MGP_FVBNJ_G0018324
protein coding gene Chr11:64953594-65201240 (+)
LP/J MGP_LPJ_G0018405
protein coding gene Chr11:68862098-69120106 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018347
protein coding gene Chr11:74223145-74486784 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018931
protein coding gene Chr11:67947197-68196522 (+)
PWK/PhJ MGP_PWKPhJ_G0017582
protein coding gene Chr11:65954246-66200218 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017370
protein coding gene Chr11:67775601-68041148 (+)
WSB/EiJ MGP_WSBEiJ_G0017860
protein coding gene Chr11:67556204-67812316 (+)



Homology
more
  • Human Ortholog
    STX8, syntaxin 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STX8, syntaxin 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CARB
  • Links
    NCBI Gene ID: 9482
    neXtProt AC: NX_Q9UNK0
    UniProt: Q9UNK0

  • Chr Location
    17p13.1; chr17:9250471-9575958 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in platelet dense granule secretion, aggregation, and thrombus stability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 55943 NCBI Gene Model | MGI Sequence Detail 240738 C57BL/6J ±  kb
transcript NM_018768 RefSeq | MGI Sequence Detail 4148 C57BL/6  
polypeptide O88983 UniProt | EBI | MGI Sequence Detail 236 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 60

    Microarray probesets 5
Other
Accession IDs
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MGI:1915004, MGI:1915791, MGI:1925545
References
more
  • Summaries
    All 45
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:218388 Golebiewska EM, et al., Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability. J Biol Chem. 2015 Jan 16;290(3):1536-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory