Tpm3
Gene Detail

Symbol

Name
ID

Tpm3
tropomyosin 3, gamma
MGI:1890149

Synonyms

gamma-TM, hTM30nm, hTMnm, skalphaTM.2, Tm5NM, Tpm5, Tpm-5, Trop-5

Feature Type

protein coding gene

Genetic Map

Chromosome 3
39.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr3:90072649-90100902 bp, + strand From VEGA annotation of GRCm38   28254 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:81889  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Tpm3

Human
homologs

Human Homolog		TPM3, tropomyosin 3
NCBI Gene ID		7170
neXtProt AC		NX_P06753
Human Synonyms		CAPM1, CFTD, HEL-189, HEL-S-82p, hscp30, NEM1, OK/SW-cl.5, TM3, TM30, TM30nm, TM5, TM-5, TPMsk3, TRK
Human Chr (Location)		1q21.2; chr1:154155304-154192135 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human TPM3

Mutations,
alleles, and
phenotypes

All mutations/alleles(79) : Gene trapped(72) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous inactivation of this gene results in early embryonic death, prior to blastocyst formation. Mice homozygous for a targeted allele lacking exon 9 exhibit dysmorphic T-tubules and contraction in skeletal muscles.

 
Human Diseases Modeled in Mice Using Tpm3 (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Tpm3 interacts with 245 markers (Mir1a-1, Mir1a-2, Mir15a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (12 annotations)

Component	cleavage furrow, cortical cytoskeleton, ...
Function	actin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	3

cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(37) cDNA(36) Other(1)
Microarray probesets(10)

Other database
links

VEGA Gene Model	OTTMUSG00000029647 (Evidence)
Ensembl Gene Model	ENSMUSG00000027940 (Evidence)
Entrez Gene	59069 (Evidence)
DFCI	TC1645776, TC1601318, TC1717380, TC1591574, TC1588549, TC1589839, TC1585602, TC1573726, TC1693948
Consensus CDS Project	CCDS38499.1, CCDS57223.1
International Mouse Knockout Project Status	Tpm3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029647	VEGA Gene Model | MGI Sequence Detail	28254	C57BL/6J
transcript	OTTMUST00000073538	VEGA | MGI Sequence Detail	2233	Not Applicable
polypeptide	OTTMUSP00000038082	VEGA | MGI Sequence Detail	285	Not Applicable

All sequences(151) RefSeq(24) UniProt(17)

Polymorphisms

SNPs within 2kb(179 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000533	Tropomyosin
Protein Ontology	PR:000016581	tropomyosin alpha-3 chain

References

(Earliest) J:20239 MacLeod AR, et al., Human hTM alpha gene: expression in muscle and nonmuscle tissue. Mol Cell Biol. 1988 Jan;8(1):433-40
(Latest) J:197956 Lees JG, et al., Tropomyosin regulates cell migration during skin wound healing. J Invest Dermatol. 2013 May;133(5):1330-9
All references(50)

Other
accession IDs

MGD-MRK-15204, MGD-MRK-15207, MGD-MRK-15242, MGI:98811