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Tpm3 Gene Detail
Summary
  • Symbol
    Tpm3
  • Name
    tropomyosin 3, gamma
  • Synonyms
    gamma-TM, hTM30nm, hTMnm, skalphaTM.2, Tm5NM, Tpm5, Tpm-5, Trop-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890149
    NCBI Gene: 59069
  • Gene Overview
    MyGene.info: TPM3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr3:90072649-90100902 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      28254 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.20 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TPM3, tropomyosin 3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    TPM3, tropomyosin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAPM1, CFTD, HEL-189, HEL-S-82p, hscp30, NEM1, OK/SW-cl.5, TM3, TM30, TM30nm, TM5, TM-5, TPM3nu, TPMsk3, TRK
  • Links
    NCBI Gene ID: 7170
    neXtProt AC: NX_P06753
    UniProt: P06753

  • Chr Location
    1q21.3; chr1:154155304-154192135 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human TPM3 associations

Human Disease Mouse Models
      
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 4 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in early embryonic death, prior to blastocyst formation. Mice homozygous for a targeted allele lacking exon 9 exhibit dysmorphic T-tubules and contraction in skeletal muscles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3
  • Tissues
    3
  • cDNA Data
    37
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029647 VEGA Gene Model | MGI Sequence Detail 28254 C57BL/6J ±  kb
    transcript OTTMUST00000073538 VEGA | MGI Sequence Detail 2233 Not Applicable  
    polypeptide OTTMUSP00000038082 VEGA | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      179 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR000533 Tropomyosin
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-15204, MGD-MRK-15207, MGD-MRK-15242, MGI:98811
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 6
      Diseases 3
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:20239 MacLeod AR, et al., Human hTM alpha gene: expression in muscle and nonmuscle tissue. Mol Cell Biol. 1988 Jan;8(1):433-40
    • Latest
      J:223487 Gineste C, et al., Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathy. PLoS One. 2014;9(9):e109066
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory