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Tpm3
Gene Detail
Symbol

Name
ID
Tpm3
tropomyosin 3, gamma
MGI:1890149
Synonyms
gamma-TM, hTM30nm, hTMnm, skalphaTM.2, Tm5NM, Tpm5, Tpm-5, Trop-5
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:90072649-90100902 bp, + strand
From VEGA annotation of GRCm38

  28254 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81889  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 zebrafish

Gene Tree: Tpm3

Human
homologs
Human Homolog TPM3, tropomyosin 3
NCBI Gene ID 7170
neXtProt AC  NX_P06753
Human Synonyms  CAPM1, CFTD, HEL-189, HEL-S-82p, hscp30, NEM1, OK/SW-cl.5, TM3, TM30, TM30nm, TM5, TM-5, TPMsk3, TRK
Human Chr (Location)  1q21.2; chr1:154155304-154192135 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TPM3
Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(72) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in early embryonic death, prior to blastocyst formation. Mice homozygous for a targeted allele lacking exon 9 exhibit dysmorphic T-tubules and contraction in skeletal muscles.
 
Interactions
Tpm3 interacts with 245 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Component cleavage furrow, cortical cytoskeleton, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(36) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000029647 (Evidence)
Ensembl Gene ModelENSMUSG00000027940 (Evidence)
Entrez Gene59069 (Evidence)
DFCITC1585602, TC1573726, TC1645776, TC1601318, TC1589839, TC1588549, TC1591574, TC1717380, TC1693948
Consensus CDS ProjectCCDS38499.1, CCDS57223.1
International Mouse Knockout Project StatusTpm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029647 VEGA Gene Model | MGI Sequence Detail 28254 C57BL/6J ±  kb
transcript OTTMUST00000073538 VEGA | MGI Sequence Detail 2233 Not Applicable 
polypeptide OTTMUSP00000038082 VEGA | MGI Sequence Detail 285 Not Applicable 

For the selected sequences
All sequences(151) RefSeq(24) UniProt(17)
Polymorphisms
SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000533 Tropomyosin
Protein Ontology PR:000016581 tropomyosin alpha-3 chain
References
(Earliest) J:20239 MacLeod AR, et al., Human hTM alpha gene: expression in muscle and nonmuscle tissue. Mol Cell Biol. 1988 Jan;8(1):433-40
(Latest) J:197956 Lees JG, et al., Tropomyosin regulates cell migration during skin wound healing. J Invest Dermatol. 2013 May;133(5):1330-9
All references(50)
Other
accession IDs
MGD-MRK-15204, MGD-MRK-15207, MGD-MRK-15242, MGI:98811

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory