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Tpm3 Gene Detail
Summary
  • Symbol
    Tpm3
  • Name
    tropomyosin 3, gamma
  • Synonyms
    gamma-TM, hTM30nm, hTMnm, skalphaTM.2, Tm5NM, Tpm5, Tpm-5, Trop-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890149
    NCBI Gene: 59069
  • Gene Overview
    MyGene.info: TPM3
Location & Maps
more
  • Sequence Map
    Chr3:90072649-90100902 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28254 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.20 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TPM3, tropomyosin 3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    TPM3, tropomyosin 3
    Orthology source: HomoloGene
  • Synonyms
    CAPM1, CFTD, HEL-189, HEL-S-82p, hscp30, NEM1, OK/SW-cl.5, TM3, TM30, TM30nm, TM5, TM-5, TPMsk3, TRK
  • Links
    NCBI Gene ID: 7170
    neXtProt AC: NX_P06753

  • Chr Location
    1q21.2; chr1:154155304-154192135 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human TPM3 associations

Human Disease Mouse Models
       Myopathy, Congenital, with Fiber-Type Disproportion; CFTD   OMIM: 255310
Nemaline Myopathy 1; NEM1   OMIM: 609284 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 4 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    81
  • Chemically induced (other)
    1
  • Gene trapped
    72
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Tpm3
  • Incidental Mutations
Homozygous inactivation of this gene results in early embryonic death, prior to blastocyst formation. Mice homozygous for a targeted allele lacking exon 9 exhibit dysmorphic T-tubules and contraction in skeletal muscles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029647 VEGA Gene Model | MGI Sequence Detail 28254 C57BL/6J ±  kb
transcript OTTMUST00000073538 VEGA | MGI Sequence Detail 2233 Not Applicable  
polypeptide OTTMUSP00000038082 VEGA | MGI Sequence Detail 285 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    179 from dbSNP Build 142
Protein
Information
less
  • UniProt
    10 Sequences
  • InterPro Domains
    IPR000533 Tropomyosin
Molecular
Reagents
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  • All nucleic 38
    cDNA 37
    Other 1

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-15204, MGD-MRK-15207, MGD-MRK-15242, MGI:98811
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:20239 MacLeod AR, et al., Human hTM alpha gene: expression in muscle and nonmuscle tissue. Mol Cell Biol. 1988 Jan;8(1):433-40
  • Latest
    J:197956 Lees JG, et al., Tropomyosin regulates cell migration during skin wound healing. J Invest Dermatol. 2013 May;133(5):1330-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory