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Tpm3 Gene Detail
Summary
  • Symbol
    Tpm3
  • Name
    tropomyosin 3, gamma
  • Synonyms
    gamma-TM, hTM30nm, hTMnm, skalphaTM.2, Tm5NM, Tpm5, Tpm-5, Trop-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890149
    NCBI Gene: 59069
  • Gene Overview
    MyGene.info: TPM3
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90072651-90100902 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890149
 protein coding gene Chr3:90072649-90100902 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027453
 protein coding gene Chr3:90338685-90366012 (+)
A/J MGP_AJ_G0027417
 protein coding gene Chr3:87343905-87371277 (+)
AKR/J MGP_AKRJ_G0027381
 protein coding gene Chr3:89481116-89513823 (+)
BALB/cJ MGP_BALBcJ_G0027426
 protein coding gene Chr3:87310942-87339425 (+)
C3H/HeJ MGP_C3HHeJ_G0027168
 protein coding gene Chr3:89655234-89689436 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027872
 protein coding gene Chr3:93726367-93767311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025224
 protein coding gene Chr3:82838909-82867972 (+)
CAST/EiJ MGP_CASTEiJ_G0026614
 protein coding gene Chr3:90026908-90054937 (+)
CBA/J MGP_CBAJ_G0027142
 protein coding gene Chr3:96972775-97004016 (+)
DBA/2J MGP_DBA2J_G0027280
 protein coding gene Chr3:86717302-86743270 (+)
FVB/NJ MGP_FVBNJ_G0027248
 protein coding gene Chr3:85051616-85080780 (+)
LP/J MGP_LPJ_G0027389
 protein coding gene Chr3:91410836-91450934 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027268
 protein coding gene Chr3:103152887-103182270 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027931
 protein coding gene Chr3:89230842-89262141 (+)
PWK/PhJ MGP_PWKPhJ_G0026348
 protein coding gene Chr3:86606292-86635466 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026167
 protein coding gene Chr3:88401831-88435320 (+)
WSB/EiJ MGP_WSBEiJ_G0026696
 protein coding gene Chr3:89623438-89651447 (+)



Homology
more
  • Human Ortholog
    TPM3, tropomyosin 3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    TPM3, tropomyosin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAPM1, CFTD, HEL-189, HEL-S-82p, hscp30, NEM1, OK/SW-cl.5, TM3, TM30, TM30nm, TM5, TM-5, TPM3nu, TPMsk3, TRK
  • Links
    NCBI Gene ID: 7170
    neXtProt AC: NX_P06753
    UniProt: P06753

  • Chr Location
    1q21.3; chr1:154155304-154192135 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human TPM3 associations

Human Disease Mouse Models
      
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 4 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in early embryonic death, prior to blastocyst formation. Mice homozygous for a targeted allele lacking exon 9 exhibit dysmorphic T-tubules and contraction in skeletal muscles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3
  • Tissues
    3
  • cDNA Data
    39
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59069 NCBI Gene Model | MGI Sequence Detail 28252 C57BL/6J ±  kb
    transcript NM_001271764 RefSeq | MGI Sequence Detail 2335 C57BL/6  
    polypeptide P21107 UniProt | EBI | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR000533 Tropomyosin
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-15204, MGD-MRK-15207, MGD-MRK-15242, MGI:98811
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Diseases 3
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:20239 MacLeod AR, et al., Human hTM alpha gene: expression in muscle and nonmuscle tissue. Mol Cell Biol. 1988 Jan;8(1):433-40
    • Latest
      J:267371 Cheng C, et al., Tropomyosin 3.5 protects the F-actin networks required for tissue biomechanical properties. J Cell Sci. 2018 Nov 29;131(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/15/2019
    MGI 6.13     		The Jackson Laboratory