Tpm3 MGI Mouse Gene Detail - MGI:1890149

Tpm3 Gene Detail

Symbol

Tpm3
Name

tropomyosin 3, gamma
Synonyms

gamma-TM, hTM30nm, hTMnm, skalphaTM.2, Tm5NM, Tpm5, Tpm-5, Trop-5

Feature Type

protein coding gene
IDs

MGI:1890149
NCBI Gene: 59069
Gene Overview

MyGene.info: TPM3

Sequence Map

Chr3:90072649-90100902 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

28254 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.20 cM
Mapping Data

1 experiment

Human Ortholog

TPM3, tropomyosin 3

Vertebrate Orthologs

5

Human Ortholog

TPM3, tropomyosin 3
Orthology source: HomoloGene, HGNC
Synonyms

CAPM1, CFTD, HEL-189, HEL-S-82p, hscp30, NEM1, OK/SW-cl.5, TM3, TM30, TM30nm, TM5, TM-5, TPMsk3, TRK
Links

HGNC:12012

NCBI Gene ID: 7170

neXtProt AC: NX_P06753

UniProt: P06753
Chr Location

1q21.3; chr1:154155304-154192135 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 81889
1 human;1 mouse;1 cattle;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: TPM3
Gene Tree

Tpm3

Diseases

2 with human TPM3 associations

Human Disease

Mouse Models

congenital fiber-type disproportion

IDs

nemaline myopathy 1

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

3 with disease annotations

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Phenotype Summary

4 phenotypes from 4 alleles in 3 genetic backgrounds
15 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

82
Chemically induced (other)

1
Gene trapped

72
Radiation induced

1
Targeted

6
Transgenic

2
Genomic Mutations

2 involving Tpm3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available

Homozygous inactivation of this gene results in early embryonic death, prior to blastocyst formation. Mice homozygous for a targeted allele lacking exon 9 exhibit dysmorphic T-tubules and contraction in skeletal muscles.

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All GO Annotations

19
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

3
Tissues

3
cDNA Data

37
Literature Summary

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tpm3

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Tpm3 interacts with 245 markers (Mir1a-1, Mir1a-2, Mir15a, ...) View All

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All Sequences

140
RefSeq

28
UniProt

12
CCDS

CCDS38499.2, CCDS57223.1, CCDS79961.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000029647	VEGA Gene Model \| MGI Sequence Detail	28254	C57BL/6J	± kb
transcript	OTTMUST00000073538	VEGA \| MGI Sequence Detail	2233	Not Applicable
polypeptide	OTTMUSP00000038082	VEGA \| MGI Sequence Detail	285	Not Applicable

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SNPs within 2kb

179 from dbSNP Build 142

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UniProt

12 Sequences
InterPro Domains

IPR000533 Tropomyosin

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All nucleic 38

cDNA 37

Other 1

Microarray probesets 10

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MGD-MRK-15204, MGD-MRK-15207, MGD-MRK-15242, MGI:98811

Summaries

All 55

Developmental Gene Expression 6

Diseases 3

Gene Ontology 8

Phenotypes 18
Earliest

J:20239 MacLeod AR, et al., Human hTM alpha gene: expression in muscle and nonmuscle tissue. Mol Cell Biol. 1988 Jan;8(1):433-40
Latest

J:223487 Gineste C, et al., Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathy. PLoS One. 2014;9(9):e109066

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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