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Gsdme Gene Detail
Summary
  • Symbol
    Gsdme
  • Name
    gasdermin E
  • Synonyms
    2310037D07Rik, 4932441K13Rik, Dfna5, Dfna5h, Fin15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889850
    NCBI Gene: 54722
  • Gene Overview
    MyGene.info: GSDME
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:50207401-50262862 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 24.13 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    479 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889850
protein coding gene Chr6:50188888-50263862 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030728
protein coding gene Chr6:49284534-49360503 (-)
A/J MGP_AJ_G0030699
protein coding gene Chr6:46988170-47066165 (-)
AKR/J MGP_AKRJ_G0030624
protein coding gene Chr6:48647074-48724200 (-)
BALB/cJ MGP_BALBcJ_G0030709
protein coding gene Chr6:47329885-47406393 (-)
C3H/HeJ MGP_C3HHeJ_G0030422
protein coding gene Chr6:48663955-48745400 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031164
protein coding gene Chr6:50397137-50477132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028371
protein coding gene Chr6:44595818-44676169 (-)
CAST/EiJ MGP_CASTEiJ_G0029826
protein coding gene Chr6:48371774-48450494 (-)
CBA/J MGP_CBAJ_G0030397
protein coding gene Chr6:52514913-52601884 (-)
DBA/2J MGP_DBA2J_G0030546
protein coding gene Chr6:46898702-46974387 (-)
FVB/NJ MGP_FVBNJ_G0030498
protein coding gene Chr6:46538842-46618345 (-)
LP/J MGP_LPJ_G0030631
protein coding gene Chr6:49241480-49318675 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030532
protein coding gene Chr6:55230327-55307319 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031193
protein coding gene Chr6:48556836-48636330 (-)
PWK/PhJ MGP_PWKPhJ_G0029538
protein coding gene Chr6:46467865-46547374 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029374
protein coding gene Chr6:47882868-47960887 (-)
WSB/EiJ MGP_WSBEiJ_G0029903
protein coding gene Chr6:48519678-48598206 (-)



Homology
more
  • Human Ortholog
    GSDME, gasdermin E
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GSDME, gasdermin E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNA5, ICERE-1
  • Links
    NCBI Gene ID: 1687
    neXtProt AC: NX_O60443
    UniProt: O60443

  • Chr Location
    7p15.3; chr7:24698355-24758020 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3242
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GSDME
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human GSDME associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal numbers of cochlear hair cell but have normal hearing. Mice homozygous for another knock-out allele exhibit normal hearing but protection from chemotherapy drug-induced tissue damage and weight loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54722 NCBI Gene Model | MGI Sequence Detail 55462 C57BL/6J ±  kb
transcript NM_018769 RefSeq | MGI Sequence Detail 2135 C57BL/6  
polypeptide Q9Z2D3 UniProt | EBI | MGI Sequence Detail 512 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 2
    cDNA 11
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-33747, MGI:106063, MGI:1921667, MGI:1923695, MGI:3703053
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
  • Latest
    J:250434 Wang Y, et al., Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017 Jul 6;547(7661):99-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory