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Tspan12
Gene Detail
 Symbol
Name
ID
Tspan12
tetraspanin 12
MGI:1889818
Synonyms Tm4sf12
Feature Type protein coding gene
Genetic Map
Chromosome 6
8.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:21771395-21852515 bp, - strand
From VEGA annotation of GRCm38

  81121 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tetraspanin
Gene Tree: Tspan12

Human
homologs
Human Homolog TSPAN12, tetraspanin 12
NCBI Gene ID 23554
neXtProt AC  NX_O95859
Human Synonyms  EVR5, NET2, NET-2, TM4SF12
Human Chr (Location)  7q31.31; chr7:120787320-120858366 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TSPAN12
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal retinal vasculature with pericapillary occlusions, lack of vertical sprouts, gliosis, fenestration, microanurysms, hemorrhage, and delayed regression of hyaloid capillaries.
 
Human Diseases Modeled Using Mouse Tspan12 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tspan12 interacts with 232 markers (Mir10a, Mir10b, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process angiogenesis, cell surface receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (65)    Tissues (65)    Images (4)
Theiler Stages: 21, 23, 27
Assay TypeResults
RNA in situ 65
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026887 (Evidence)
Ensembl Gene ModelENSMUSG00000029669 (Evidence)
Entrez Gene269831 (Evidence)
UniGene21950
DFCITC1575010, TC1596201
NIA Mouse Gene IndexU027073
Consensus CDS ProjectCCDS19935.1
International Mouse Knockout Project StatusTspan12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026887 VEGA Gene Model | MGI Sequence Detail 81121 C57BL/6J ±  kb
transcript OTTMUST00000066499 VEGA | MGI Sequence Detail 2490 Not Applicable 
polypeptide OTTMUSP00000033328 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(476 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000301 Tetraspanin
InterPro IPR018503 Tetraspanin, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000016738 tetraspanin-12
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Disease annotation references (1)
Other
accession IDs
MGI:2141465, MGI:2141646

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory