Tspan12
Gene Detail

Symbol Name ID

Tspan12 tetraspanin 12 MGI:1889818

Synonyms

Tm4sf12

Feature Type

protein coding gene

Genetic Map

Chromosome 6

8.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:21771395-21852515 bp, - strand From VEGA annotation of GRCm38   81121 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tetraspanin
Gene Tree: Tspan12

Human homologs

Human Homolog		TSPAN12, tetraspanin 12
NCBI Gene ID		23554
neXtProt AC		NX_O95859
Human Synonyms		EVR5, NET2, NET-2, TM4SF12
Human Chr (Location)		7q31.31; chr7:120427374-120498177 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TSPAN12

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele exhibit abnormal retinal vasculature with pericapillary occlusions, lack of vertical sprouts, gliosis, fenestration, microanurysms, hemorrhage, and delayed regression of hyaloid capillaries.

 
Human Diseases Modeled Using Mouse Tspan12 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	angiogenesis, cell surface receptor signaling pathway, ...
Component	integral to membrane, integral to plasma membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (65)    Tissues (65)    Images (4)
Theiler Stages: 21, 23, 28

Assay Type	Results
RNA in situ	65

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) cDNA(45)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026887 (Evidence)
Ensembl Gene Model	ENSMUSG00000029669 (Evidence)
Entrez Gene	269831 (Evidence)
UniGene	21950
DFCI	TC1575010, TC1596201
NIA Mouse Gene Index	U027073
Consensus CDS Project	CCDS19935.1
International Mouse Knockout Project Status	Tspan12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026887	VEGA Gene Model | MGI Sequence Detail	81121	C57BL/6J
transcript	OTTMUST00000066499	VEGA | MGI Sequence Detail	2490	Not Applicable
polypeptide	OTTMUSP00000033328	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(452 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000301	Tetraspanin
InterPro	IPR018503	Tetraspanin, conserved site
InterPro	IPR008952	Tetraspanin, EC2 domain
InterPro	IPR018499	Tetraspanin/Peripherin
Protein Ontology	PR:000016738	tetraspanin-12

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)

Other accession IDs

MGI:2141465, MGI:2141646