Gp6
Gene Detail

Symbol Name ID

Gp6 glycoprotein 6 (platelet) MGI:1889810

Synonyms

9830166G18Rik, Gpvi

Feature Type

protein coding gene

Genetic Map

Chromosome 7

2.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:4368713-4397744 bp, - strand From NCBI annotation of GRCm38   29032 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9488  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 dog

Gene Tree: Gp6

Human homologs

Human Homolog		GP6, glycoprotein VI (platelet)
NCBI Gene ID		51206
neXtProt AC		NX_Q9HCN6
Human Synonyms		BDPLT11, GPIV, GPVI
Human Chr (Location)		19q13.4; chr19:55525073-55549632 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GP6

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous with disruptions in this gene display functional abnormalities in their platelets including failure of the platelets to aggregate and to become activated. The effects on blood clotting are minor however.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	blood coagulation, hemostasis
Component	integral to membrane, integral to plasma membrane, ...
Function	collagen binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (31)    Tissues (30)   
Theiler Stages: 20, 21, 22, 24, 26, 28

Assay Type	Results
RNA in situ	31

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(4) Primer pair(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000078810 (Evidence)
Entrez Gene	243816 (Evidence)
UniGene	248662
DFCI	TC1624504, TC1680381
DoTS	DT.101705436, DT.91422310
NIA Mouse Gene Index	U028081
Consensus CDS Project	CCDS51972.1
International Mouse Knockout Project Status	Gp6

Sequences

Length	Strain/Species
genomic	243816	NCBI Gene Model | MGI Sequence Detail	29032	C57BL/6J
transcript	NM_001163014	RefSeq | MGI Sequence Detail	1152	C57BL/6
polypeptide	P0C191	UniProt | EBI | MGI Sequence Detail	313	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
Protein Ontology	PR:000008156	platelet glycoprotein VI

Graphical View of Protein Domain Structure

References

(Earliest) J:64221 Jandrot-Perrus M, et al., Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 2000 Sep 1;96(5):1798-807
(Latest) J:170699 Boilard E, et al., Platelets Participate in Synovitis via Cox-1-Dependent Synthesis of Prostacyclin Independently of Microparticle Generation. J Immunol. 2011 Apr 1;186(7):4361-6
All references(29)

Other accession IDs

MGI:2685315