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Gp6
Gene Detail
Symbol

Name
ID
Gp6
glycoprotein 6 (platelet)
MGI:1889810
Synonyms
9830166G18Rik, Gpvi
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:4368713-4397744 bp, - strand
From Ensembl annotation of GRCm38

  29032 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9488  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

Gene Tree: Gp6

Human
homologs
Human Homolog GP6, glycoprotein VI (platelet)
NCBI Gene ID 51206
neXtProt AC  NX_Q9HCN6
Human Synonyms  BDPLT11, GPIV, GPVI
Human Chr (Location)  19q13.4; chr19:55013705-55038264 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GP6
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous with disruptions in this gene display functional abnormalities in their platelets including failure of the platelets to aggregate and to become activated. The effects on blood clotting are minor however.
 
Interactions
Gp6 interacts with 31 markers (Mir20a, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process blood coagulation, hemostasis
Component cell surface, extracellular vesicular exosome, ...
Function collagen binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000078810 (Evidence)
Entrez Gene243816 (Evidence)
UniGene248662
DFCITC1680381, TC1624504
DoTSDT.91422310, DT.101705436, DT.101129658
NIA Mouse Gene IndexU198662, U028081
Consensus CDS ProjectCCDS51972.1
International Mouse Knockout Project StatusGp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078810 Ensembl Gene Model | MGI Sequence Detail 29032 C57BL/6J ±  kb
transcript ENSMUST00000108590 Ensembl | MGI Sequence Detail 1152 Not Applicable 
polypeptide ENSMUSP00000104231 Ensembl | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(200 from dbSNP Build 137)    SNPs within 2kb including multiple locations(202)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000008156 platelet glycoprotein VI
References
(Earliest) J:64221 Jandrot-Perrus M, et al., Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 2000 Sep 1;96(5):1798-807
(Latest) J:206377 Pokidysheva E, et al., Biological role of prolyl 3-hydroxylation in type IV collagen. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):161-6
All references(35)
Other
accession IDs
MGI:2685315

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory