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Gp6
Gene Detail
 Symbol
Name
ID
Gp6
glycoprotein 6 (platelet)
MGI:1889810
Synonyms 9830166G18Rik, Gpvi
Feature Type protein coding gene
Genetic Map
Chromosome 7
2.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:4368713-4397744 bp, - strand
From NCBI annotation of GRCm38

  29032 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9488  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog

Gene Tree: Gp6

Human
homologs
Human Homolog GP6, glycoprotein VI (platelet)
NCBI Gene ID 51206
neXtProt AC  NX_Q9HCN6
Human Synonyms  BDPLT11, GPIV, GPVI
Human Chr (Location)  19q13.4; chr19:55013705-55038264 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GP6
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous with disruptions in this gene display functional abnormalities in their platelets including failure of the platelets to aggregate and to become activated. The effects on blood clotting are minor however.
 
Interactions
Gp6 interacts with 31 markers (Mir20a, Mir30a, Mir30d, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process blood coagulation, hemostasis
Component extracellular vesicular exosome, integral component of membrane, ...
Function collagen binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (31)    Tissues (29)   
Theiler Stages: 20, 21, 22, 24, 26, 28
Assay TypeResults
RNA in situ 31
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000078810 (Evidence)
Entrez Gene243816 (Evidence)
UniGene248662
DFCITC1624504, TC1680381
DoTSDT.101129658, DT.101705436, DT.91422310
NIA Mouse Gene IndexU028081, U198662
Consensus CDS ProjectCCDS51972.1
International Mouse Knockout Project StatusGp6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 243816 NCBI Gene Model | MGI Sequence Detail 29032 C57BL/6J ±  kb
transcript NM_001163014 RefSeq | MGI Sequence Detail 1152 C57BL/6 
polypeptide P0C191 UniProt | EBI | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(200 from dbSNP Build 137)    SNPs within 2kb including multiple locations(202)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000008156 platelet glycoprotein VI
Graphical View of Protein Domain Structure
References (Earliest) J:64221 Jandrot-Perrus M, et al., Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 2000 Sep 1;96(5):1798-807
(Latest) J:209493 Schaff M, et al., Integrin alpha6beta1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis. Circulation. 2013 Jul 30;128(5):541-52
All references(34)
Other
accession IDs
MGI:2685315

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory