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Hibadh Gene Detail
Summary
  • Symbol
    Hibadh
  • Name
    3-hydroxyisobutyrate dehydrogenase
  • Synonyms
    6430402H10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889802
    NCBI Gene: 58875
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52546230-52640300 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 25.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    398 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889802
protein coding gene Chr6:52546228-52640389 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030752
protein coding gene Chr6:51821397-51921996 (-)
A/J MGP_AJ_G0030721
protein coding gene Chr6:49400529-49495368 (-)
AKR/J MGP_AKRJ_G0030648
protein coding gene Chr6:51112950-51211974 (-)
BALB/cJ MGP_BALBcJ_G0030733
protein coding gene Chr6:49747061-49842467 (-)
C3H/HeJ MGP_C3HHeJ_G0030446
protein coding gene Chr6:51121803-51217447 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031188
protein coding gene Chr6:52961234-53063069 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028394
protein coding gene Chr6:47024954-47124395 (-)
CAST/EiJ MGP_CASTEiJ_G0029849
protein coding gene Chr6:50935693-51038942 (-)
CBA/J MGP_CBAJ_G0030420
protein coding gene Chr6:55182955-55286027 (-)
DBA/2J MGP_DBA2J_G0030570
protein coding gene Chr6:49313795-49407725 (-)
FVB/NJ MGP_FVBNJ_G0030522
protein coding gene Chr6:48914052-49008235 (-)
LP/J MGP_LPJ_G0030655
protein coding gene Chr6:51776754-51877111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030556
protein coding gene Chr6:57781762-57899483 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031218
protein coding gene Chr6:51053019-51154022 (-)
PWK/PhJ MGP_PWKPhJ_G0029562
protein coding gene Chr6:48935220-49029273 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029396
protein coding gene Chr6:50371675-50470982 (-)
WSB/EiJ MGP_WSBEiJ_G0029926
protein coding gene Chr6:51050390-51148744 (-)



Homology
more
  • Human Ortholog
    HIBADH, 3-hydroxyisobutyrate dehydrogenase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HIBADH, 3-hydroxyisobutyrate dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NS5ATP1
  • Links
    NCBI Gene ID: 11112
    neXtProt AC: NX_P31937
    UniProt: P31937

  • Chr Location
    7p15.2; chr7:27525440-27663001 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58875 NCBI Gene Model | MGI Sequence Detail 94071 C57BL/6J ±  kb
    transcript NM_145567 RefSeq | MGI Sequence Detail 1748 Not Specified  
    polypeptide Q99L13 UniProt | EBI | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008549 3-hydroxyisobutyrate dehydrogenase, mitochondrial
    • EC
    • InterPro Domains
      IPR011548 3-hydroxyisobutyrate dehydrogenase
      IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain
      IPR015815 3-hydroxyisobutyrate dehydrogenase-related
      IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site
      IPR013328 6-phosphogluconate dehydrogenase, domain 2
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
      IPR036291 NAD(P)-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 173

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory