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Trim54
Gene Detail
Symbol

Name
ID
Trim54
tripartite motif-containing 54
MGI:1889623
Synonyms
4930486E09Rik, 4930566I02Rik, MuRF3, Rnf30
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.06 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:31116712-31137630 bp, + strand
From VEGA annotation of GRCm38

  20919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: TRIM54
Gene Tree: Trim54

Human
homologs
TRIM54, tripartite motif containing 54
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57159
neXtProt AC: NX_Q9BYV2

Human Synonyms: MURF, muRF3, MURF-3, RNF30

Human Chr (Location): 2p23.3; chr2:27282429-27307439 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Radiation induced(3) Targeted(2)
Genomic Mutations involving Trim54 (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit normal cardiac function but are prone to cardiac rupture after acute myocardial infarction.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Trim54 interacts with 16 markers (Mir137, Mir146, Mir146b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, cytoskeleton, ...
Function metal ion binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (53)    Tissues (36)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 33
Northern blot 8
Western blot 11
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN trim54    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022416 (Evidence)
Ensembl Gene Model ENSMUSG00000062077 (Evidence)
Entrez Gene 58522 (Evidence)
UniGene 143796
DFCI TC1586255, TC1697883, TC1776937
DoTS DT.55155148, DT.110657453
NIA Mouse Gene Index U005437
Consensus CDS Project CCDS19173.1
International Mouse Phenotyping Consortium Status Trim54
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022416 VEGA Gene Model | MGI Sequence Detail 20919 C57BL/6J ±  kb
transcript OTTMUST00000053597 VEGA | MGI Sequence Detail 1434 Not Applicable 
polypeptide OTTMUSP00000025488 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017903 COS domain
InterPro IPR000315 Zinc finger, B-box
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016661 tripartite motif-containing protein 54
References
(Earliest) J:63980 Spencer JA, et al., Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein. J Cell Biol. 2000 Aug 21;150(4):771-84
(Latest) J:170578 Perera S, et al., Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover. Dev Biol. 2011 Mar 1;351(1):46-61
All references(38)
Other
accession IDs
MGI:1922577, MGI:1925423

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory