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Trim54
Gene Detail
 Symbol
Name
ID
Trim54
tripartite motif-containing 54
MGI:1889623
Synonyms 4930486E09Rik, 4930566I02Rik, MuRF3, Rnf30
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.06 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:31116712-31137630 bp, + strand
From VEGA annotation of GRCm38

  20919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Trim54

Human
homologs
Human Homolog TRIM54, tripartite motif containing 54
NCBI Gene ID 57159
neXtProt AC  NX_Q9BYV2
Human Synonyms  MURF, muRF3, MURF-3, RNF30
Human Chr (Location)  2p23.3; chr2:27282429-27307439 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Radiation induced(2) Targeted(2)
Genomic Mutations involving Trim54 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal cardiac function but are prone to cardiac rupture after acute myocardial infarction.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Trim54 interacts with 16 markers (Mir137, Mir146, Mir146b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, cytoskeleton, ...
Function metal ion binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (53)    Tissues (36)    Images (10)
Theiler Stages: 13, 15, 17, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 33
Northern blot 8
Western blot 11
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022416 (Evidence)
Ensembl Gene ModelENSMUSG00000062077 (Evidence)
Entrez Gene58522 (Evidence)
UniGene143796
DFCITC1586255, TC1697883, TC1776937
DoTSDT.110657453, DT.55155148
NIA Mouse Gene IndexU005437
Consensus CDS ProjectCCDS19173.1
International Mouse Knockout Project StatusTrim54
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022416 VEGA Gene Model | MGI Sequence Detail 20919 C57BL/6J ±  kb
transcript OTTMUST00000053597 VEGA | MGI Sequence Detail 1434 Not Applicable 
polypeptide OTTMUSP00000025488 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017903 COS domain
InterPro IPR000315 Zinc finger, B-box
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016661 tripartite motif-containing protein 54
References (Earliest) J:63980 Spencer JA, et al., Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein. J Cell Biol. 2000 Aug 21;150(4):771-84
(Latest) J:170578 Perera S, et al., Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover. Dev Biol. 2011 Mar 1;351(1):46-61
All references(40)
Other
accession IDs
MGI:1922577, MGI:1925423

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory