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Trim54 Gene Detail
Summary
  • Symbol
    Trim54
  • Name
    tripartite motif-containing 54
  • Synonyms
    4930486E09Rik, 4930566I02Rik, MuRF3, Rnf30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889623
    NCBI Gene: 58522
Location & Maps
more
  • Sequence Map
    Chr5:31116712-31137630 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20919 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.06 cM, cytoband B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TRIM54, tripartite motif containing 54
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TRIM54, tripartite motif containing 54
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MURF, muRF3, MURF-3, RNF30
  • Links
    NCBI Gene ID: 57159
    neXtProt AC: NX_Q9BYV2

  • Chr Location
    2p23.3; chr2:27282429-27307439 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    6 involving Trim54
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit normal cardiac function but are prone to cardiac rupture after acute myocardial infarction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022416 VEGA Gene Model | MGI Sequence Detail 20919 C57BL/6J ±  kb
transcript OTTMUST00000053597 VEGA | MGI Sequence Detail 1434 Not Applicable  
polypeptide OTTMUSP00000025488 VEGA | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    113 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000016661 tripartite motif-containing protein 54
  • InterPro Domains
    IPR000315 B-box-type zinc finger
    IPR017903 COS domain
    IPR027370 RING-type zinc-finger, LisH dimerisation motif
    IPR033492 Tripartite motif-containing protein 54
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
    IPR017907 Zinc finger, RING-type, conserved site
Molecular
Reagents
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  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
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MGI:1922577, MGI:1925423
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 3
    Phenotypes 28
  • Earliest
    J:63980 Spencer JA, et al., Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein. J Cell Biol. 2000 Aug 21;150(4):771-84
  • Latest
    J:170578 Perera S, et al., Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover. Dev Biol. 2011 Mar 1;351(1):46-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory