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Ppp1r1a
Gene Detail
 Symbol
Name
ID
Ppp1r1a
protein phosphatase 1, regulatory (inhibitor) subunit 1A
MGI:1889595
Synonyms 0610038N18Rik, I-1, inhibitor-1, protein phosphatase inhibitor-1
Feature Type protein coding gene
Genetic Map
Chromosome 15
59.01 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:103530279-103537992 bp, - strand
From NCBI annotation of GRCm38

  7714 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: protein phosphatase inhibitor 1
Gene Tree: Ppp1r1a

Human
homologs
Human Homolog PPP1R1A, protein phosphatase 1, regulatory (inhibitor) subunit 1A
NCBI Gene ID 5502
neXtProt AC  NX_Q13522
Human Synonyms  I1, IPP1
Human Chr (Location)  12q13.2; chr12:54579240-54588659 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show decreased long term poteniation, but normal performance in water maze tests.
 
Interactions
Ppp1r1a interacts with 121 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process carbohydrate metabolic process, glycogen metabolic process, ...
Component cytoplasm, extracellular space
Function protein binding, protein phosphatase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (245)    Tissues (105)    Images (42)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 93
RNA in situ 152
cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(1) cDNA(35)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022490 (Evidence)
Entrez Gene58200 (Evidence)
UniGene143788
DFCITC1580037, TC1608241
DoTSDT.492317, DT.94291447
NIA Mouse Gene IndexU036716
Consensus CDS ProjectCCDS37237.1
International Mouse Knockout Project StatusPpp1r1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 58200 NCBI Gene Model | MGI Sequence Detail 7714 C57BL/6J ±  kb
transcript NM_021391 RefSeq | MGI Sequence Detail 1295 C57BL/6 
polypeptide Q9ERT9 UniProt | EBI | MGI Sequence Detail 171 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008466 Protein phosphatase inhibitor, 1DARPP-32
Protein Ontology PR:000013120 protein phosphatase 1 regulatory subunit 1A
Graphical View of Protein Domain Structure
References (Earliest) J:62800 Svenningsson P, et al., Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. J Neurochem. 2000 Jul;75(1):248-57
(Latest) J:211018 Pritchard TJ, et al., Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts. PLoS One. 2013;8(12):e80717
All references(40)
Other
accession IDs
MGI:1915628

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory