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Sh3kbp1
Gene Detail
Symbol

Name
ID
Sh3kbp1
SH3-domain kinase binding protein 1
MGI:1889583
Synonyms
1200007H22Rik, 1700125L08Rik, 5830464D22Rik, IN85, Ruk, Seta
Feature Type
protein coding gene
Genetic Map
Chromosome X
73.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:159627272-159978069 bp, + strand
From VEGA annotation of GRCm38

  350798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sh3kbp1

Human
homologs
Human Homolog SH3KBP1, SH3-domain kinase binding protein 1
NCBI Gene ID 30011
neXtProt AC  NX_Q96B97
Human Synonyms  CD2BP3, CIN85, GIG10, HSB1, HSB-1, MIG18
Human Chr (Location)  Xp22.1-p21.3; chrX:19533965-19887626 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Radiation induced(1) Spontaneous(1) Targeted(2)
Genomic Mutations involving Sh3kbp1 (2)
 
Mice homozygous for a null allele have an increased lean body mass, increased dopamine in the striatum and behavioral abnormalities.
 
Interactions
Sh3kbp1 interacts with 464 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, cell migration, ...
Component cell-cell junction, cell junction, ...
Function protein binding, SH3 domain binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019443 VEGA Gene Model | MGI Sequence Detail 350798 C57BL/6J ±  kb
transcript OTTMUST00000046427 VEGA | MGI Sequence Detail 2280 Not Applicable 
polypeptide OTTMUSP00000020962 VEGA | MGI Sequence Detail 709 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(30) UniProt(7)
Polymorphisms
SNPs within 2kb(1295 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019394 Predicted transmembrane/coiled-coil 2 protein
InterPro IPR013315 Spectrin alpha chain, SH3 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000014828 SH3 domain-containing kinase-binding protein 1
References
(Earliest) J:64312 Hyatt MA, et al., Assignment of seta to distal mouse X chromosome by radiation hybrid mapping. Cytogenet Cell Genet. 2000;89(3-4):278
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(41)
Other
accession IDs
MGI:1914697, MGI:1920887, MGI:1923337, MGI:2147886

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory