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Sh3kbp1
Gene Detail
Symbol

Name
ID
Sh3kbp1
SH3-domain kinase binding protein 1
MGI:1889583
Synonyms
1200007H22Rik, 1700125L08Rik, 5830464D22Rik, IN85, Ruk, Seta
Feature Type
protein coding gene
Genetic Map
Chromosome X
73.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:159627272-159978069 bp, + strand
From VEGA annotation of GRCm38

  350798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SH3KBP1
Gene Tree: Sh3kbp1

Human
homologs
SH3KBP1, SH3-domain kinase binding protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 30011
neXtProt AC: NX_Q96B97

Human Synonyms: CD2BP3, CIN85, GIG10, HSB1, HSB-1, MIG18

Human Chr (Location): Xp22.1-p21.3; chrX:19533965-19887626 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Radiation induced(1) Spontaneous(1) Targeted(2)
Genomic Mutations involving Sh3kbp1 (2)
Incidental mutations (data from CvDC )
 
Mice homozygous for a null allele have an increased lean body mass, increased dopamine in the striatum and behavioral abnormalities.
 
Interactions
Sh3kbp1 interacts with 464 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, cell migration, ...
Component cell-cell junction, cell junction, ...
Function protein binding, SH3 domain binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sh3kbp1    NEW 
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000019443 (Evidence)
Ensembl Gene Model ENSMUSG00000040990 (Evidence)
Entrez Gene 58194 (Evidence)
DFCI TC1630010, TC1603776, TC1635393, TC1653293, TC1585444, TC1575307, TC1596066, TC1703509, TC1777744
DoTS DT.101183401, DT.91342523, DT.101738811, DT.101738812, DT.60100937, DT.87039257, DT.529829, DT.94212084, DT.91591955, DT.94294168, DT.94212090
NIA Mouse Gene Index U020364
PDB 2DA9, 1WI7
Consensus CDS Project CCDS41194.1, CCDS53234.1, CCDS53235.1
International Mouse Phenotyping Consortium Status Sh3kbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019443 VEGA Gene Model | MGI Sequence Detail 350798 C57BL/6J ±  kb
transcript OTTMUST00000046427 VEGA | MGI Sequence Detail 2280 Not Applicable 
polypeptide OTTMUSP00000020962 VEGA | MGI Sequence Detail 709 Not Applicable 

For the selected sequences
All sequences(148) RefSeq(32) UniProt(7)
Polymorphisms
SNPs within 2kb(1295 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019394 Predicted transmembrane/coiled-coil 2 protein
InterPro IPR013315 Spectrin alpha chain, SH3 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000014828 SH3 domain-containing kinase-binding protein 1
References
(Earliest) J:64312 Hyatt MA, et al., Assignment of seta to distal mouse X chromosome by radiation hybrid mapping. Cytogenet Cell Genet. 2000;89(3-4):278
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(40)
Other
accession IDs
MGI:1914697, MGI:1920887, MGI:1923337, MGI:2147886

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory