Sh3kbp1
Gene Detail

Symbol

Name
ID

Sh3kbp1
SH3-domain kinase binding protein 1
MGI:1889583

Synonyms

1200007H22Rik, 1700125L08Rik, 5830464D22Rik, IN85, Ruk, Seta

Feature Type

protein coding gene

Genetic Map

Chromosome X
73.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:159627272-159978069 bp, + strand From VEGA annotation of GRCm38   350798 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:10971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sh3kbp1

Human
homologs

Human Homolog		SH3KBP1, SH3-domain kinase binding protein 1
NCBI Gene ID		30011
neXtProt AC		NX_Q96B97
Human Synonyms		CD2BP3, CIN85, GIG10, HSB1, HSB-1, MIG18
Human Chr (Location)		Xp22.1-p21.3; chrX:19533965-19887626 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(6) : Gene trapped(2) Radiation induced(1) Spontaneous(1) Targeted(2)
Genomic Mutations involving Sh3kbp1 (2)
 

Mice homozygous for a null allele have an increased lean body mass, increased dopamine in the striatum and behavioral abnormalities.

 

Interactions

Sh3kbp1 interacts with 464 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (16 annotations)

Process	apoptotic process, cell migration, ...
Component	cell-cell junction, cell junction, ...
Function	protein binding, SH3 domain binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	1

cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(8)

Other database
links

VEGA Gene Model	OTTMUSG00000019443 (Evidence)
Ensembl Gene Model	ENSMUSG00000040990 (Evidence)
Entrez Gene	58194 (Evidence)
DFCI	TC1777744, TC1596066, TC1603776, TC1635393, TC1703509, TC1630010, TC1653293, TC1575307, TC1585444
DoTS	DT.94212090, DT.94294168, DT.94212084, DT.91591955, DT.87039257, DT.60100937, DT.529829, DT.101183401, DT.101738811, DT.101738812, DT.91342523
NIA Mouse Gene Index	U020364
PDB	2DA9, 1WI7
Consensus CDS Project	CCDS41194.1, CCDS53234.1, CCDS53235.1
International Mouse Knockout Project Status	Sh3kbp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019443	VEGA Gene Model | MGI Sequence Detail	350798	C57BL/6J
transcript	OTTMUST00000046427	VEGA | MGI Sequence Detail	2280	Not Applicable
polypeptide	OTTMUSP00000020962	VEGA | MGI Sequence Detail	709	Not Applicable

All sequences(152) RefSeq(30) UniProt(13)

Polymorphisms

SNPs within 2kb(1295 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR019394	Predicted transmembrane/coiled-coil 2 protein
InterPro	IPR013315	Spectrin alpha chain, SH3 domain
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000014828	SH3 domain-containing kinase-binding protein 1

References

(Earliest) J:64312 Hyatt MA, et al., Assignment of seta to distal mouse X chromosome by radiation hybrid mapping. Cytogenet Cell Genet. 2000;89(3-4):278
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(42)

Other
accession IDs

MGI:1914697, MGI:1920887, MGI:1923337, MGI:2147886