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Extl2 Gene Detail
Summary
  • Symbol
    Extl2
  • Name
    exostoses (multiple)-like 2
  • Synonyms
    3000001D04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889574
    NCBI Gene: 58193
  • Gene Overview
    MyGene.info: EXTL2
Location & Maps
more
  • Sequence Map
    Chr3:116007462-116029017 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21556 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 50.17 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EXTL2, exostosin like glycosyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXTL2, exostosin like glycosyltransferase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EXTR2
  • Links
    NCBI Gene ID: 2135
    neXtProt AC: NX_Q9UBQ6

  • Chr Location
    1p21; chr1:100872372-100895323 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1102
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: EXTL2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Extl2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased production of heparin sulfate and chondroitin sulfate in mouse embryonic fibroblasts, liver and brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022635 VEGA Gene Model | MGI Sequence Detail 21556 C57BL/6J ±  kb
transcript OTTMUST00000054229 VEGA | MGI Sequence Detail 3000 Not Applicable  
polypeptide OTTMUSP00000025856 VEGA | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    195 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 55
    cDNA 52
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGI:1926138, MGI:2139976
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:64307 Wuyts W, et al., Characterization and genomic localization of the mouse Extl2 gene. Cytogenet Cell Genet. 2000;89(3-4):185-8
  • Latest
    J:215420 Nadanaka S, et al., EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis. Matrix Biol. 2014 Apr;35:18-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory