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Gsdma Gene Detail
Summary
  • Symbol
    Gsdma
  • Name
    gasdermin A
  • Synonyms
    Gsdm, Gsdm1, Gsdma1, H312E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889509
    NCBI Gene: 57911
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98664351-98677708 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889509
protein coding gene Chr11:98664337-98677708 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019067
protein coding gene Chr11:101255996-101269270 (+)
A/J MGP_AJ_G0019035
protein coding gene Chr11:97019891-97033665 (+)
AKR/J MGP_AKRJ_G0019005
protein coding gene Chr11:100027986-100041974 (+)
BALB/cJ MGP_BALBcJ_G0019009
protein coding gene Chr11:97512413-97528701 (+)
C3H/HeJ MGP_C3HHeJ_G0018822
protein coding gene Chr11:100157576-100183703 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019460
protein coding gene Chr11:104342255-104355533 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017092
protein coding gene Chr11:94577025-94590089 (+)
CAST/EiJ MGP_CASTEiJ_G0018376
protein coding gene Chr11:101146034-101165926 (+)
CBA/J MGP_CBAJ_G0018793
protein coding gene Chr11:108694975-108720605 (+)
DBA/2J MGP_DBA2J_G0018901
protein coding gene Chr11:96579650-96592910 (+)
FVB/NJ MGP_FVBNJ_G0018890
protein coding gene Chr11:96079118-96100009 (+)
LP/J MGP_LPJ_G0018971
protein coding gene Chr11:101716426-101730654 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018917
protein coding gene Chr11:108418434-108435630 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019500
protein coding gene Chr11:100367300-100383127 (+)
PWK/PhJ MGP_PWKPhJ_G0018147
protein coding gene Chr11:97599902-97620248 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0018425
protein coding gene Chr11:100320870-100334469 (+)



Homology
more
  • Human Ortholog
    GSDMA, gasdermin A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GSDMA, gasdermin A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKSG9, GSDM, GSDM1
  • Links
    NCBI Gene ID: 284110
    neXtProt AC: NX_Q96QA5
    UniProt: Q96QA5

  • Chr Location
    17q21.1; chr17:39962973-39977880 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017204 Ensembl Gene Model | MGI Sequence Detail 13358 C57BL/6J ±  kb
transcript ENSMUST00000017348 Ensembl | MGI Sequence Detail 2726 Not Applicable  
polypeptide ENSMUSP00000017348 Ensembl | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 1
    cDNA 26
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144607
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:218441 Tanaka S, et al., Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. G3 (Bethesda). 2013 Oct;3(10):1843-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory