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Crlf2
Gene Detail
Symbol

Name
ID
Crlf2
cytokine receptor-like factor 2
MGI:1889506
Synonyms
Ly114, Tpte2, Tslpr
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:109554711-109558993 bp, - strand
From Ensembl annotation of GRCm38

  4283 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49476  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CRLF2
Gene Tree: Crlf2

Human
homologs
CRLF2, cytokine receptor-like factor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64109
neXtProt AC: NX_Q9HC73

Human Synonyms: CRL2, CRLF2Y, TSLPR

Human Chr (Location): XYp22.3; Yp11.3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are overtly normal and maintain normal lymphopoiesis.
 
Interactions
Crlf2 interacts with 19 markers (Mir153, Mir183, Mir434, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process immunoglobulin secretion involved in immune response, inflammatory response, ...
Component cell, extracellular region, ...
Function cytokine activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (33)    Tissues (16)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 33
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(39)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000033467 (Evidence)
Entrez Gene 57914 (Evidence)
UniGene 35771
DFCI TC1735788, TC1595683, TC1581705
DoTS DT.94153589, DT.101336854, DT.490054, DT.101341123, DT.101162550
NIA Mouse Gene Index U026545
PDB 4NN5, 4NN7, 4NN6
Consensus CDS Project CCDS19521.1
International Mouse Phenotyping Consortium Status Crlf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033467 Ensembl Gene Model | MGI Sequence Detail 4283 C57BL/6J ±  kb
transcript ENSMUST00000044579 Ensembl | MGI Sequence Detail 1325 Not Applicable 
polypeptide ENSMUSP00000036326 Ensembl | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000005886 cytokine receptor-like factor 2
References
(Earliest) J:61515 Fujio K, et al., Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain. Blood. 2000 Apr 1;95(7):2204-10
(Latest) J:213356 Patton DT, et al., The development and survival but not function of follicular B cells is dependent on IL-7Ralpha Tyr449 signaling. PLoS One. 2014;9(2):e88771
All references(80)
Other
accession IDs
MGI:1355298

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory