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Crlf2
Gene Detail
 Symbol
Name
ID
Crlf2
cytokine receptor-like factor 2
MGI:1889506
Synonyms Ly114, Tpte2, Tslpr
Feature Type protein coding gene
Genetic Map
Chromosome 5
53.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:109554711-109558993 bp, - strand
From Ensembl annotation of GRCm38

  4283 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49476  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Crlf2

Human
homologs
Human Homolog CRLF2, cytokine receptor-like factor 2
NCBI Gene ID 64109
neXtProt AC  NX_Q9HC73
Human Synonyms  CRL2, CRLF2Y, TSLPR
Human Chr (Location)  XYp22.3; Yp11.3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are overtly normal and maintain normal lymphopoiesis.
 
Interactions
Crlf2 interacts with 19 markers (Mir153, Mir183, Mir434, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process immunoglobulin secretion involved in immune response, inflammatory response, ...
Component cell, extracellular region, ...
Function cytokine activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (33)    Tissues (16)    Images (11)
Theiler Stages: 23
Assay TypeResults
RNA in situ 33
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(39)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033467 (Evidence)
Entrez Gene57914 (Evidence)
UniGene35771
DFCITC1581705, TC1595683, TC1735788
DoTSDT.101162550, DT.101336854, DT.101341123, DT.490054, DT.94153589
NIA Mouse Gene IndexU026545
PDB4NN5, 4NN6, 4NN7
Consensus CDS ProjectCCDS19521.1
International Mouse Knockout Project StatusCrlf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033467 Ensembl Gene Model | MGI Sequence Detail 4283 C57BL/6J ±  kb
transcript ENSMUST00000044579 Ensembl | MGI Sequence Detail 1325 Not Applicable 
polypeptide ENSMUSP00000036326 Ensembl | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(10) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000005886 cytokine receptor-like factor 2
References (Earliest) J:61515 Fujio K, et al., Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain. Blood. 2000 Apr 1;95(7):2204-10
(Latest) J:210323 Van Dyken SJ, et al., Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells. Immunity. 2014 Mar 20;40(3):414-24
All references(79)
Other
accession IDs
MGI:1355298

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory