B3gnt2
Gene Detail

Symbol Name ID

B3gnt2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 MGI:1889505

Synonyms

B3Galt6, B3gnt1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

14.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:22834747-22860961 bp, - strand From VEGA annotation of GRCm38   26215 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human B3gnt2 ± 2 cM)

Gene Tree: B3gnt2

Human ortholog

B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 NCBI Gene ID 10678
Human Synonyms: B3GNT, B3GNT1, B3GN-T2, B3GNT-2, BETA3GNT, BGnT-2, BGNT2
Human Chr2:62423262-62451866 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Homozygotes for a gene trap allele show severe axon guidance errors and specific loss of olfactory sensory neurons and glomeruli. Homozygotes for another gene trap allele show hyperactive lymphocytes and macrophages. Homozygotes for a reporter allele display behavioral despair and reduced anxiety.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	axon guidance, protein glycosylation, ...
Component	Golgi apparatus, integral to membrane, ...
Function	galactosyltransferase activity, transferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (205)    Tissues (152)    Images (10)
Theiler Stages: 19, 21, 22, 28

Assay Type	Results
RNA in situ	94
In situ reporter (knock in)	58
Northern blot	16
RT-PCR	37

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005266 (Evidence)
Ensembl Gene Model	ENSMUSG00000051650 (Evidence)
Entrez Gene	53625 (Evidence)
DFCI	TC1575950
EC	2.4.1.-
Consensus CDS Project	CCDS24471.1
International Mouse Knockout Project Status	B3gnt2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005266	VEGA Gene Model | MGI Sequence Detail	26215	C57BL/6J
transcript	OTTMUST00000011735	VEGA | MGI Sequence Detail	3057	Not Applicable
polypeptide	OTTMUSP00000005434	VEGA | MGI Sequence Detail	397	Not Applicable

All sequences(41) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002659	Glycosyl transferase, family 31
Protein Ontology	PR:000004592	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

References

(Earliest) J:62502 Zhou D, et al., A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):406-11
(Latest) J:185365 Knott TK, et al., Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance. Neural Dev. 2012;7:17
All references(35)

Other accession IDs

MGI:1890585, MGI:2143981, MGI:2143995, MGI:2144521