Ap1s2
Gene Detail

Symbol Name ID

Ap1s2 adaptor-related protein complex 1, sigma 2 subunit MGI:1889383

Synonyms

1500012A13Rik, EST1

Feature Type

protein coding gene

Genetic Map

Chromosome X

75.97 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

ChrX:163909017-163933666 bp, + strand From VEGA annotation of GRCm38   24650 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap1s2

Human homologs

Human Homolog		AP1S2, adaptor-related protein complex 1, sigma 2 subunit
NCBI Gene ID		8905
neXtProt AC		NX_P56377
Human Synonyms		MGC:1902, MRX59, MRXS21, MRXSF, SIGMA1B
Human Chr (Location)		Xp22.2; chrX:15843929-15873100 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AP1S2

Alleles and phenotypes

All alleles(8) : Targeted(4) Gene trapped(4)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	endocytosis, intracellular protein transport, ...
Component	coated pit, cytoplasmic vesicle, ...
Function	protein transporter activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (2)    Images (3)
Theiler Stages: 23

Assay Type	Results
RNA in situ	6

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(12)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000019515 (Evidence)
Ensembl Gene Model	ENSMUSG00000031367 (Evidence)
Entrez Gene	108012 (Evidence)
DFCI	TC1575758, TC1589124, TC1609636, TC1706981, TC1759267
DoTS	DT.101287884, DT.486222
NIA Mouse Gene Index	U020380
Consensus CDS Project	CCDS30514.1
International Mouse Knockout Project Status	Ap1s2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019515	VEGA Gene Model | MGI Sequence Detail	24650	C57BL/6J
transcript	OTTMUST00000046603	VEGA | MGI Sequence Detail	2226	Not Applicable
polypeptide	OTTMUSP00000021045	VEGA | MGI Sequence Detail	160	Not Applicable

All sequences(50) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016635	Adaptor protein complex, sigma subunit
InterPro	IPR022775	AP complex, mu/sigma subunit
InterPro	IPR000804	Clathrin adaptor complex, small chain
InterPro	IPR011012	Longin-like domain
Protein Ontology	PR:000004097	AP-1 complex subunit sigma-2

References

(Earliest) J:63696 Blair HJ, et al., Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome. Mamm Genome. 2000 Aug;11(8):710-2
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(36)

Other accession IDs

MGI:1916210, MGI:2147933