About   Help   FAQ
Ap1s2
Gene Detail
Symbol

Name
ID
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
MGI:1889383
Synonyms
1500012A13Rik, EST1
Feature Type
protein coding gene
Genetic Map
Chromosome X
75.97 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:163909017-163933666 bp, + strand
From VEGA annotation of GRCm38

  24650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AP1S2
Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap1s2

Human
homologs
AP1S2, adaptor-related protein complex 1, sigma 2 subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8905
neXtProt AC: NX_P56377

Human Synonyms: DC22, MRX59, MRXS21, MRXS5, MRXSF, PGS, SIGMA1B

Human Chr (Location): Xp22.2; chrX:15825806-15855014 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Targeted(5)
Incidental mutations (data from APF )
Interactions
Ap1s2 interacts with 336 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process adipose tissue development, fat cell differentiation, ...
Component cell, coated pit, ...
Function protein binding, protein transporter activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (5)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
RT-PCR 6
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ap1s2    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000019515 (Evidence)
Ensembl Gene Model ENSMUSG00000031367 (Evidence)
Entrez Gene 108012 (Evidence)
DFCI TC1575758, TC1589124, TC1609636, TC1706981, TC1759267
DoTS DT.101287884, DT.486222
NIA Mouse Gene Index U020380
Consensus CDS Project CCDS30514.1, CCDS72465.1, CCDS72466.1
International Mouse Phenotyping Consortium Status Ap1s2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019515 VEGA Gene Model | MGI Sequence Detail 24650 C57BL/6J ±  kb
transcript OTTMUST00000046603 VEGA | MGI Sequence Detail 2226 Not Applicable 
polypeptide OTTMUSP00000021045 VEGA | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(11) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016635 Adaptor protein complex, sigma subunit
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR000804 Clathrin adaptor complex, small chain
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004097 AP-1 complex subunit sigma-2
References
(Earliest) J:63696 Blair HJ, et al., Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome. Mamm Genome. 2000 Aug;11(8):710-2
(Latest) J:216244 Baltes J, et al., sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. J Cell Sci. 2014 Aug 15;127(Pt 16):3477-87
All references(36)
Other
accession IDs
MGI:1916210, MGI:2147933

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory