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Il17re Gene Detail
Summary
  • Symbol
    Il17re
  • Name
    interleukin 17 receptor E
  • Synonyms
    Il25r
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889371
    NCBI Gene: 57890
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:113458484-113470758 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12275 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.76 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IL17RE, interleukin 17 receptor E
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL17RE, interleukin 17 receptor E
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 132014
    neXtProt AC: NX_Q8NFR9
    UniProt: Q8NFR9

  • Chr Location
    3p25.3; chr3:9902086-9916402 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit increased susceptibility to DSS-induced colitis, imiquimod-induced psoriasis, and C. rodentium bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000056372 VEGA Gene Model | MGI Sequence Detail 12275 C57BL/6J ±  kb
    transcript OTTMUST00000139287 VEGA | MGI Sequence Detail 2940 Not Applicable  
    polypeptide OTTMUSP00000073096 VEGA | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      110 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR027841 Interleukin-17 receptor C/E, N-terminal
      IPR013568 SEFIR domain
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 4
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 13
    • Earliest
      J:87486 Akeson EC, Chromosomal inversion discovered in C3H/HeJ mice. JAX Notes. 2003;491:15
    • Latest
      J:233410 Conti HR, et al., Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis. PLoS One. 2015;10(4):e0122807

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory