Zfp318 MGI Mouse Gene Detail - MGI:1889348

Symbol

Zfp318
Name

zinc finger protein 318
Synonyms

2610034E08Rik, D530032D06Rik, TZF

Feature Type

protein coding gene
IDs

MGI:1889348
NCBI Gene: 57908
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:46694657-46731846 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 22.90 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

575 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889348	protein coding gene	Chr17:46694444-46731846 (+)
129S1/SvImJ	ENSMUSG00200026861	protein coding gene	Chr17:41894148-41931358 (+)
A/J	ENSMUSG00195020253	protein coding gene	Chr17:43398039-43435228 (+)
AKR/J	ENSMUSG00220030765	protein coding gene	Chr17:42383491-42420672 (+)
BALB/cJ	ENSMUSG00180018454	protein coding gene	Chr17:43148275-43185456 (+)
C3H/HeJ	ENSMUSG00175014202	protein coding gene	Chr17:42462180-42499358 (+)
C57BL/6NJ	ENSMUSG00215011946	protein coding gene	Chr17:42017456-42054642 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021668	protein coding gene	Chr17:43094906-43132061 (+)
CAST/EiJ	ENSTCUG00005021613	protein coding gene	Chr17:43179303-43216634 (+)
CBA/J	ENSMUSG00210030262	protein coding gene	Chr17:42211907-42249085 (+)
DBA/2J	ENSMUSG00185028323	protein coding gene	Chr17:45117251-45154436 (+)
FVB/NJ	ENSMUSG00205028883	protein coding gene	Chr17:42687783-42725026 (+)
JF1/MsJ	ENSUMUG00000017846	protein coding gene	Chr17:44735864-44773261 (+)
LP/J	ENSMUSG00230038917	protein coding gene	Chr17:46008953-46046169 (+)
NOD/ShiLtJ	ENSMUSG00190015111	protein coding gene	Chr17:42099719-42137099 (+)
NZO/HlLtJ	ENSMUSG00225042380	protein coding gene	Chr17:48264740-48301929 (+)
PWK/PhJ	ENSLUMG00010028565	protein coding gene	Chr17:41972951-42010312 (+)
SPRET/EiJ	ENSMSPG00010031475	protein coding gene	Chr17:42175175-42212292 (+)
WSB/EiJ	ENSIUOG00005025008	protein coding gene	Chr17:43060787-43097966 (+)

Human Ortholog

ZNF318, zinc finger protein 318

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF318, zinc finger protein 318
Synonyms

HRIHFB2436, TZF, ZFP318
Links

HGNC:13578

NCBI Gene ID: 24149

UniProt: Q5VUA4
Chr Location

6p21.1; chr6:43307134-43369647 (-) GRCh38

MGI Vertebrate Homology

Zfp318 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF318
Gene Tree

Zfp318

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Phenotype Summary

9 phenotypes from 4 alleles in 4 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (ENU)

2
Endonuclease-mediated

4
Gene trapped

3
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

82 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit reduced male fertility and altered IgM and IgD levels. Null mutants displayed normal level of circulating B cells with decreased IgD and increased IgM levels.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

662
Tissues

62
cDNA Data

68
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

7
UniProt

3
CCDS

CCDS28826.2, CCDS28827.2

Ensembl

ENSMUSG00000015597 (Evidence)
NCBI Gene

57908

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015597	Ensembl Gene Model \| MGI Sequence Detail	37190	C57BL/6J	± kb
transcript	ENSMUST00000113481	Ensembl \| MGI Sequence Detail	13060	Not Applicable
polypeptide	ENSMUSP00000109109	Ensembl \| MGI Sequence Detail	2237	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017821 zinc finger protein 318

(term hierarchy)
InterPro Domains

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR055309 Zinc finger protein 318-like

IPR060578 Zinc finger protein 318-like, helical domain
GlyGen

Q99PP2 10 sites, 1 O-linked glycan (7 sites)

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All nucleic 69

cDNA 68

Primer pair 1

Microarray probesets 8

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MGI:1916488, MGI:1925838

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 13
Earliest

J:63318 Inoue A, et al., The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. Biochem Biophys Res Commun. 2000 Jul 5;273(2):398-403
Latest

J:338642 Xu Y, et al., Rad52 mediates class-switch DNA recombination to IgD. Nat Commun. 2022 Feb 21;13(1):980

TSS for Zfp318:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144848	Chr17:46694469-46694492 (+)	-176 bp
Tssr144849	Chr17:46694495-46694548 (+)	-135 bp
Tssr144850	Chr17:46694651-46694718 (+)	28 bp
Tssr144851	Chr17:46694724-46694748 (+)	79 bp
Tssr144852	Chr17:46721812-46721822 (+)	27,160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24