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Zfp318 Gene Detail
Summary
  • Symbol
    Zfp318
  • Name
    zinc finger protein 318
  • Synonyms
    2610034E08Rik, D530032D06Rik, TZF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889348
    NCBI Gene: 57908
  • Gene Overview
    MyGene.info: ZNF318
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46383731-46420920 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889348
protein coding gene Chr17:46383504-46420920 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023813
protein coding gene Chr17:47434017-47472162 (+)
A/J MGP_AJ_G0023771
protein coding gene Chr17:46304293-46341147 (+)
AKR/J MGP_AKRJ_G0023742
protein coding gene Chr17:46643473-46681903 (+)
BALB/cJ MGP_BALBcJ_G0023775
protein coding gene Chr17:46201151-46238418 (+)
C3H/HeJ MGP_C3HHeJ_G0023539
protein coding gene Chr17:47384448-47422097 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024218
protein coding gene Chr17:49492352-49531932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021668
protein coding gene Chr17:43094906-43132061 (+)
CAST/EiJ MGP_CASTEiJ_G0023020
protein coding gene Chr17:47463738-47501019 (+)
CBA/J MGP_CBAJ_G0023515
protein coding gene Chr17:51260639-51303056 (+)
DBA/2J MGP_DBA2J_G0023641
protein coding gene Chr17:45082698-45120008 (+)
FVB/NJ MGP_FVBNJ_G0023608
protein coding gene Chr17:44690871-44731568 (+)
LP/J MGP_LPJ_G0023722
protein coding gene Chr17:48121599-48159660 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023637
protein coding gene Chr17:50822852-50862781 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024263
protein coding gene Chr17:46996621-47034159 (+)
PWK/PhJ MGP_PWKPhJ_G0022765
protein coding gene Chr17:44417366-44455900 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022580
protein coding gene Chr17:43868353-43906198 (+)
WSB/EiJ MGP_WSBEiJ_G0023085
protein coding gene Chr17:47536312-47576902 (+)



Homology
more
  • Human Ortholog
    ZNF318, zinc finger protein 318
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ZNF318, zinc finger protein 318
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRIHFB2436, TZF, ZFP318
  • Links
    NCBI Gene ID: 24149
    neXtProt AC: NX_Q5VUA4
    UniProt: Q5VUA4

  • Chr Location
    6p21.1; chr6:43327489-43369676 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit reduced male fertility and altered IgM and IgD levels. Null mutants displayed normal level of circulating B cells with decreased IgD and increased IgM levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015597 Ensembl Gene Model | MGI Sequence Detail 37190 C57BL/6J ±  kb
    transcript ENSMUST00000113481 Ensembl | MGI Sequence Detail 13060 Not Applicable  
    polypeptide ENSMUSP00000109109 Ensembl | MGI Sequence Detail 2237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 68
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1916488, MGI:1925838
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:63318 Inoue A, et al., The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. Biochem Biophys Res Commun. 2000 Jul 5;273(2):398-403
    • Latest
      J:260664 Ishizuka M, et al., Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice. Dev Growth Differ. 2016 Sep;58(7):600-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory