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Sit1
Gene Detail
 Symbol
Name
ID
Sit1
suppression inducing transmembrane adaptor 1
MGI:1889342
Synonyms Sit
Feature Type protein coding gene
Genetic Map
Chromosome 4
23.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:43482081-43483734 bp, - strand
From VEGA annotation of GRCm38

  1654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8694  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Sit1

Human
homologs
Human Homolog SIT1, signaling threshold regulating transmembrane adaptor 1
NCBI Gene ID 27240
neXtProt AC  NX_Q9Y3P8
Human Synonyms  SIT, SIT-R
Human Chr (Location)  9p13-p12; chr9:35649298-35650950 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit altered T-cell development, thymus hyperplasia, decreased lymph node cellularity and are more susceptible to develop experimental autoimmune encephalomyelitis.
 
Interactions
Sit1 interacts with 85 markers (Mir15a, Mir98, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process immune system process, regulation of T cell activation
Component extracellular vesicular exosome, integral component of membrane, ...
Function kinase binding
External Resources: FuncBase
Expression
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006916 (Evidence)
Ensembl Gene ModelENSMUSG00000028460 (Evidence)
Entrez Gene54390 (Evidence)
UniGene31775
DFCITC1586033
DoTSDT.40146285
NIA Mouse Gene IndexU024987
Consensus CDS ProjectCCDS18096.1
International Mouse Knockout Project StatusSit1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006916 VEGA Gene Model | MGI Sequence Detail 1654 C57BL/6J ±  kb
transcript OTTMUST00000015960 VEGA | MGI Sequence Detail 1228 Not Applicable 
polypeptide OTTMUSP00000007334 VEGA | MGI Sequence Detail 180 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000014894 signaling threshold-regulating transmembrane adapter 1
References (Earliest) J:62650 Marie-Cardine A, et al., SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J Exp Med. 1999 Apr 19;189(8):1181-94
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory