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Rbm38 Gene Detail
Summary
  • Symbol
    Rbm38
  • Name
    RNA binding motif protein 38
  • Synonyms
    Rnpc1, Seb4l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889294
    NCBI Gene: 56190
Location & Maps
more
  • Sequence Map
    Chr2:173020498-173034734 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14237 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 95.67 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RBM38, RNA binding motif protein 38
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RBM38, RNA binding motif protein 38
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ800J21.2, HSRNASEB, RNPC1, SEB4B, SEB4D
  • Links
    NCBI Gene ID: 55544
    neXtProt AC: NX_Q9H0Z9

  • Chr Location
    20q13.31; chr20:57391398-57409333 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
Mice homozygous for a null mutation display premature aging and death with increased tumor incidence and hematopoietic defects including extramedullary hematopoiesis and anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016681 VEGA Gene Model | MGI Sequence Detail 14237 C57BL/6J ±  kb
transcript OTTMUST00000040393 VEGA | MGI Sequence Detail 2071 Not Applicable  
polypeptide OTTMUSP00000018046 VEGA | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013796 RNA-binding protein 38
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 73
    Genomic 1
    cDNA 70
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:63186 Fetka I, et al., Expression of the RNA recognition motif-containing protein SEB-4 during xenopus embryonic development. Mech Dev. 2000 Jun;94(1-2):283-6
  • Latest
    J:216929 Zhang J, et al., Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18637-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory