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Fxyd1
Gene Detail
Symbol

Name
ID
Fxyd1
FXYD domain-containing ion transport regulator 1
MGI:1889273
Synonyms
0610012C17Rik, 1110006M24Rik, phospholemman, PLM, PML
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.29 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:31051681-31055656 bp, - strand
From Ensembl annotation of GRCm38

  3976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: FXYD1
Protein SuperFamily: FXYD domain-containing ion transport regulator
Gene Tree: Fxyd1

Human
homologs
FXYD1, FXYD domain containing ion transport regulator 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5348
neXtProt AC: NX_O00168

Human Synonyms: PLM

Human Chr (Location): 19q13.1; chr19:35138789-35143055 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Adult mice homozygous for a knock-out allele exhibit cardiac hypertrophy, increased ejection fraction, and a 50% reduction in total Na-K-ATPase activity.
 
Interactions
Fxyd1 interacts with 33 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process chloride transport, cytosolic calcium ion homeostasis, ...
Component caveola, chloride channel complex, ...
Function ATPase binding, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (35)    Tissues (19)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
Northern blot 12
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fxyd1    NEW 
Molecular
reagents
All nucleic(67) cDNA(67)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000036570 (Evidence)
Entrez Gene 56188 (Evidence)
UniGene 1491
DFCI TC1594264, TC1594751, TC1580017, TC1594753, TC1590381
DoTS DT.94372723, DT.494307, DT.91339748, DT.94372724, DT.99869162
NIA Mouse Gene Index U028411
Consensus CDS Project CCDS21123.1
International Mouse Phenotyping Consortium Status Fxyd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036570 Ensembl Gene Model | MGI Sequence Detail 3976 C57BL/6J ±  kb
transcript ENSMUST00000039909 Ensembl | MGI Sequence Detail 620 Not Applicable 
polypeptide ENSMUSP00000048460 Ensembl | MGI Sequence Detail 92 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(22) UniProt(1)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000272 Ion-transport regulator, FXYD motif
Protein Ontology PR:000007713 phospholemman
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206550 Matagne V, et al., Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome. Brain Res. 2013 Feb 16;1496:104-14
All references(45)
Other
accession IDs
MGI:1915607, MGI:1915796

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory