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Fxyd1
Gene Detail
Symbol

Name
ID
Fxyd1
FXYD domain-containing ion transport regulator 1
MGI:1889273
Synonyms
0610012C17Rik, 1110006M24Rik, phospholemman, PLM, PML
Feature Type
protein coding gene
Genetic Map
Chromosome 7
19.29 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:31051681-31055656 bp, - strand
From Ensembl annotation of GRCm38

  3976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: FXYD domain-containing ion transport regulator
Gene Tree: Fxyd1

Human
homologs
Human Homolog FXYD1, FXYD domain containing ion transport regulator 1
NCBI Gene ID 5348
neXtProt AC  NX_O00168
Human Synonyms  PLM
Human Chr (Location)  19q13.1; chr19:35138789-35143055 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Adult mice homozygous for a knock-out allele exhibit cardiac hypertrophy, increased ejection fraction, and a 50% reduction in total Na-K-ATPase activity.
 
Interactions
Fxyd1 interacts with 33 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular calcium ion homeostasis, chloride transport, ...
Component cell, chloride channel complex, ...
Function chloride channel activity, ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (35)    Tissues (19)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
Northern blot 12
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(67)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000036570 (Evidence)
Entrez Gene56188 (Evidence)
UniGene1491
DFCITC1590381, TC1580017, TC1594751, TC1594753, TC1594264
DoTSDT.91339748, DT.494307, DT.94372724, DT.94372723, DT.99869162
NIA Mouse Gene IndexU028411
Consensus CDS ProjectCCDS21123.1
International Mouse Knockout Project StatusFxyd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036570 Ensembl Gene Model | MGI Sequence Detail 3976 C57BL/6J ±  kb
transcript ENSMUST00000039909 Ensembl | MGI Sequence Detail 620 Not Applicable 
polypeptide ENSMUSP00000048460 Ensembl | MGI Sequence Detail 92 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(14) UniProt(1)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000272 Ion-transport regulator, FXYD motif
Protein Ontology PR:000007713 phospholemman
References
(Earliest) J:64123 Sweadner KJ, et al., The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics. 2000 Aug 15;68(1):41-56
(Latest) J:206550 Matagne V, et al., Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome. Brain Res. 2013 Feb 16;1496:104-14
All references(47)
Other
accession IDs
MGI:1915607, MGI:1915796

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory