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Cks1b Gene Detail
Summary
  • Symbol
    Cks1b
  • Name
    CDC28 protein kinase 1b
  • Synonyms
    2410005G18Rik, 2610005D03Rik, Cks1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889208
    NCBI Gene: 54124
  • Gene Overview
    MyGene.info: CKS1B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89415472-89418291 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889208
protein coding gene Chr3:89415472-89418383 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027438
protein coding gene Chr3:89630146-89633015 (-)
A/J MGP_AJ_G0027402
protein coding gene Chr3:86663555-86666488 (-)
AKR/J MGP_AKRJ_G0027366
protein coding gene Chr3:88760300-88763280 (-)
BALB/cJ MGP_BALBcJ_G0027411
protein coding gene Chr3:86630846-86633769 (-)
C3H/HeJ MGP_C3HHeJ_G0027153
protein coding gene Chr3:88963922-88966860 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027857
protein coding gene Chr3:93016274-93019181 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025209
protein coding gene Chr3:82145898-82149171 (-)
CAST/EiJ MGP_CASTEiJ_G0026599
protein coding gene Chr3:89320316-89323227 (-)
CBA/J MGP_CBAJ_G0027127
protein coding gene Chr3:96205937-96208854 (-)
DBA/2J MGP_DBA2J_G0027265
protein coding gene Chr3:86041270-86044230 (-)
FVB/NJ MGP_FVBNJ_G0027233
protein coding gene Chr3:84384150-84387089 (-)
LP/J MGP_LPJ_G0027374
protein coding gene Chr3:90709538-90712429 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027253
protein coding gene Chr3:102415770-102418651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027916
protein coding gene Chr3:88515683-88519445 (-)
PWK/PhJ MGP_PWKPhJ_G0026333
protein coding gene Chr3:85919178-85922469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026152
protein coding gene Chr3:87689622-87692919 (-)
WSB/EiJ MGP_WSBEiJ_G0026681
protein coding gene Chr3:88909204-88912101 (-)



Homology
more
  • Human Ortholog
    CKS1B, CDC28 protein kinase regulatory subunit 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CKS1B, CDC28 protein kinase regulatory subunit 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CKS1, ckshs1, PNAS-16, PNAS-18
  • Links
    NCBI Gene ID: 1163
    neXtProt AC: NX_P61024
    UniProt: P61024

  • Chr Location
    1q21.3; chr1:154974642-154979249 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele exhibit a reduced body size that persists through adulthood while heterozygous mice are intermediate in size. Mutant mouse embryonic fibroblasts (MEFs) proliferate poorly and senesce earlier than wild-type MEFs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54124 NCBI Gene Model | MGI Sequence Detail 2820 C57BL/6J ±  kb
    transcript NM_016904 RefSeq | MGI Sequence Detail 757 Not Specified  
    polypeptide P61025 UniProt | EBI | MGI Sequence Detail 79 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005518 cyclin-dependent kinases regulatory subunit 1
    • InterPro Domains
      IPR000789 Cyclin-dependent kinase, regulatory subunit
      IPR036858 Cyclin-dependent kinase, regulatory subunit superfamily
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 124
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913740, MGI:1914364, MGI:2139555
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:251921 Fish K, et al., EBV latent membrane protein 2A orchestrates p27(kip1) degradation via Cks1 to accelerate MYC-driven lymphoma in mice. Blood. 2017 Dec 7;130(23):2516-2526

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory