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Cks1b
Gene Detail
Symbol

Name
ID
Cks1b
CDC28 protein kinase 1b
MGI:1889208
Synonyms
2410005G18Rik, 2610005D03Rik, Cks1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:89415472-89418383 bp, - strand
From VEGA annotation of GRCm38

  2912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123798  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cell division control protein
Gene Tree: Cks1b

Human
homologs
Human Homolog CKS1B, CDC28 protein kinase regulatory subunit 1B
NCBI Gene ID 1163
neXtProt AC  NX_P61024
Human Synonyms  CKS1, ckshs1, PNAS-16, PNAS-18
Human Chr (Location)  1q21.2; chr1:154974642-154979249 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Gene trapped(55) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Embryos homozygous for a knock-out allele exhibit a reduced body size that persists through adulthood while heterozygous mice are intermediate in size. Mutant mouse embryonic fibroblasts (MEFs) proliferate poorly and senesce earlier than wild-type MEFs.
 
Interactions
Cks1b interacts with 63 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process cell cycle, cell division
Function cyclin-dependent protein serine/threonine kinase regulator activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (16)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 16
cDNA source data(122)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) cDNA(123) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022072 (Evidence)
Ensembl Gene ModelENSMUSG00000028044 (Evidence)
Entrez Gene54124 (Evidence)
UniGene3049
DFCITC1574185
DoTSDT.495664, DT.94394085
NIA Mouse Gene IndexU024283, U349552
Consensus CDS ProjectCCDS38493.1
International Mouse Knockout Project StatusCks1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022072 VEGA Gene Model | MGI Sequence Detail 2912 C57BL/6J ±  kb
transcript OTTMUST00000052412 VEGA | MGI Sequence Detail 849 Not Applicable 
polypeptide OTTMUSP00000024854 VEGA | MGI Sequence Detail 79 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(9)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000789 Cyclin-dependent kinase, regulatory subunit
Protein Ontology PR:000005518 cyclin-dependent kinases regulatory subunit 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187223 Kratzat S, et al., Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies. PLoS One. 2012;7(5):e37433
All references(49)
Other
accession IDs
MGI:1913740, MGI:1914364, MGI:2139555

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory