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Skap2
Gene Detail
Symbol

Name
ID
Skap2
src family associated phosphoprotein 2
MGI:1889206
Synonyms
2610021A10Rik, mSKAP55R, RA70, Saps, SKAP-HOM
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:51859166-52012549 bp, - strand
From Ensembl annotation of GRCm38

  153384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2919  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Skap2

Human
homologs
Human Homolog SKAP2, src kinase associated phosphoprotein 2
NCBI Gene ID 8935
neXtProt AC  NX_O75563
Human Synonyms  PRAP, RA70, SAPS, SCAP2, SKAP55R, SKAP-HOM
Human Chr (Location)  7p15.2; chr7:26657778-26864722 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(119) : Gene trapped(117) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene-trapped allele exhibit impaired B-cell responses, altered B-cell adhesion, decreased serum immunoglobulin levels, decreased susceptibility to experimental autoimmune encephalomyelitis, and abnormal dendritic cell physiology.
 
Interactions
Skap2 interacts with 72 markers (Mir27a, Mir27b, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process B cell activation, negative regulation of cell proliferation
Component cytoplasm, nucleus, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000059182 (Evidence)
Entrez Gene54353 (Evidence)
DFCITC1691017, TC1596925, TC1576296
DoTSDT.491962, DT.101306784, DT.101725886, DT.55213107
NIA Mouse Gene IndexU027299, U356035
PDB2OTX, 1U5F, 1U5G, 1U5E
Consensus CDS ProjectCCDS20137.1
International Mouse Knockout Project StatusSkap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059182 Ensembl Gene Model | MGI Sequence Detail 153384 C57BL/6J ±  kb
transcript ENSMUST00000078214 Ensembl | MGI Sequence Detail 1638 Not Applicable 
polypeptide ENSMUSP00000077342 Ensembl | MGI Sequence Detail 358 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(1012 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000014905 src kinase-associated phosphoprotein 2
References
(Earliest) J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
(Latest) J:203536 Ayoub E, et al., Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility. J Biol Chem. 2013 Sep 6;288(36):25739-48
All references(49)
Other
accession IDs
MGI:1889379, MGI:1922074, MGI:3035219

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory