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Cd200r1 Gene Detail
Summary
  • Symbol
    Cd200r1
  • Name
    CD200 receptor 1
  • Synonyms
    CD200R, Mox2r, OX2R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889024
    NCBI Gene: 57781
Location & Maps
more
  • Sequence Map
    Chr16:44765736-44794978 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29243 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.08 cM, cytoband B5
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CD200R1, CD200 receptor 1
  • Vertebrate Orthologs
    15
  • Human Ortholog
    CD200R1, CD200 receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD200R, HCRTR2, MOX2R, OX2R
  • Links
    NCBI Gene ID: 131450
    neXtProt AC: NX_Q8TD46

  • Chr Location
    3q13.2; chr3:112921057-112975122 (-)  GRCh38.p2

  • Human Ortholog
    CD200R1L, CD200 receptor 1 like
    Orthology source: HGNC
  • Synonyms
    CD200R2, CD200RLa
  • Links
    NCBI Gene ID: 344807
    neXtProt AC: NX_Q6Q8B3

  • Chr Location
    3q13.2; chr3:112812239-112846889 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption of this gene display abnormal sleep patterns including fragmented vigilance states and diminished duration of wakefulness. Mice homozygous for a different knock-out allele exhibit protection from HSV-1 encephalitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014978 VEGA Gene Model | MGI Sequence Detail 29243 C57BL/6J ±  kb
transcript OTTMUST00000035557 VEGA | MGI Sequence Detail 1892 Not Applicable  
polypeptide OTTMUSP00000015932 VEGA | MGI Sequence Detail 326 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    175 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:64171 Wright GJ, et al., Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity. 2000 Aug;13(2):233-42
  • Latest
    J:207783 Horie S, et al., CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization. Sci Rep. 2013;3:3072

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory