Cd200r1
Gene Detail

Symbol Name ID

Cd200r1 CD200 receptor 1 MGI:1889024

Synonyms

CD200R, Mox2r, OX2R

Feature Type

protein coding gene

Genetic Map

Chromosome 16

29.08 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr16:44765736-44794978 bp, + strand From VEGA annotation of GRCm38   29243 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 2 dog; 2 chicken

Gene Tree: Cd200r1

Human homologs

Human Homolog		CD200R1, CD200 receptor 1
NCBI Gene ID		131450
neXtProt AC		NX_Q8TD46
Human Synonyms		CD200R, HCRTR2, MOX2R, OX2R
Human Chr (Location)		3q13.2; chr3:112641532-112693937 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a disruption of this gene display abnormal sleep patterns including fragmented vigilance states and diminished duration of wakefulness. Mice homozygous for a different knock-out allele exhibit protection from HSV-1 encephalitis.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Component	external side of plasma membrane, integral to membrane, ...
Function	protein binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (67)    Tissues (32)    Images (32)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	67

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014978 (Evidence)
Ensembl Gene Model	ENSMUSG00000022667 (Evidence)
Entrez Gene	57781 (Evidence)
UniGene	416152
DFCI	TC1575356, TC1589785, TC1622412
NIA Mouse Gene Index	U017167
Consensus CDS Project	CCDS28189.1
International Mouse Knockout Project Status	Cd200r1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014978	VEGA Gene Model | MGI Sequence Detail	29243	C57BL/6J
transcript	OTTMUST00000035557	VEGA | MGI Sequence Detail	1892	Not Applicable
polypeptide	OTTMUSP00000015932	VEGA | MGI Sequence Detail	326	Not Applicable

All sequences(33) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(171 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013162	CD80-like, immunoglobulin C2-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000005161	cell surface glycoprotein CD200 receptor 1

References

(Earliest) J:64171 Wright GJ, et al., Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity. 2000 Aug;13(2):233-42
(Latest) J:192198 Soberman RJ, et al., CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2. PLoS One. 2012;7(10):e47740
All references(43)