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Cd200r1 Gene Detail
Summary
  • Symbol
    Cd200r1
  • Name
    CD200 receptor 1
  • Synonyms
    CD200R, Mox2r, OX2R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889024
    NCBI Gene: 57781
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:44765736-44794977 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.08 cM, cytoband B5
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889024
protein coding gene Chr16:44765736-44794978 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022843
protein coding gene Chr16:43533277-43570046 (+)
A/J MGP_AJ_G0022808
protein coding gene Chr16:41586609-41617353 (+)
AKR/J MGP_AKRJ_G0022780
protein coding gene Chr16:42910232-42938231 (+)
BALB/cJ MGP_BALBcJ_G0022809
protein coding gene Chr16:41577599-41612001 (+)
C3H/HeJ MGP_C3HHeJ_G0022573
protein coding gene Chr16:43114003-43142878 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023256
protein coding gene Chr16:44522048-44554727 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020771
protein coding gene Chr16:41623812-41659186 (+)
CAST/EiJ MGP_CASTEiJ_G0022099
protein coding gene Chr16:43307351-43338989 (+)
CBA/J MGP_CBAJ_G0022544
protein coding gene Chr16:46409606-46450085 (+)
DBA/2J MGP_DBA2J_G0022676
protein coding gene Chr16:41321262-41352455 (+)
FVB/NJ MGP_FVBNJ_G0022651
protein coding gene Chr16:41274205-41304530 (+)
LP/J MGP_LPJ_G0022744
protein coding gene Chr16:43260548-43301108 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022670
protein coding gene Chr16:45789857-45824697 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023271
protein coding gene Chr16:42941568-42974465 (+)
PWK/PhJ MGP_PWKPhJ_G0021839
protein coding gene Chr16:41695345-41725319 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021670
protein coding gene Chr16:42853635-42889634 (+)
WSB/EiJ MGP_WSBEiJ_G0022143
protein coding gene Chr16:43036696-43075033 (+)



Homology
more
  • Human Ortholog
    CD200R1, CD200 receptor 1
  • Vertebrate Orthologs
    15
  • Human Ortholog
    CD200R1, CD200 receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD200R, HCRTR2, MOX2R, OX2R
  • Links
    NCBI Gene ID: 131450
    neXtProt AC: NX_Q8TD46
    UniProt: Q8TD46

  • Chr Location
    3q13.2; chr3:112922685-112975090 (-)  GRCh38.p7

  • Human Ortholog
    CD200R1L, CD200 receptor 1 like
    Orthology source: HGNC
  • Synonyms
    CD200R2, CD200RLa
  • Links
    NCBI Gene ID: 344807
    neXtProt AC: NX_Q6Q8B3
    UniProt: Q6Q8B3

  • Chr Location
    3q13.2; chr3:112814925-112847004 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption of this gene display abnormal sleep patterns including fragmented vigilance states and diminished duration of wakefulness. Mice homozygous for a different knock-out allele exhibit protection from HSV-1 encephalitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57781 NCBI Gene Model | MGI Sequence Detail 29242 C57BL/6J ±  kb
transcript NM_021325 RefSeq | MGI Sequence Detail 1891 C57BL/6  
polypeptide Q9ES57 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 4
References
more
  • Summaries
    All 56
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:64171 Wright GJ, et al., Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity. 2000 Aug;13(2):233-42
  • Latest
    J:251895 Oda SK, et al., A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia. Blood. 2017 Nov 30;130(22):2410-2419

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory