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Sncb
Gene Detail
Symbol

Name
ID
Sncb
synuclein, beta
MGI:1889011
Synonyms
betaSYN
Feature Type
protein coding gene
Genetic Map
Chromosome 13
29.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:54758860-54766595 bp, - strand
From VEGA annotation of GRCm38

  7736 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: synuclein
Gene Tree: Sncb

Human
homologs
Human Homolog SNCB, synuclein, beta
NCBI Gene ID 6620
neXtProt AC  NX_Q16143
Human Chr (Location)  5q35; chr5:176620209-176630556 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SNCB
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Sncb (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Sncb interacts with 137 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process dopamine metabolic process, negative regulation of neuron apoptotic process, ...
Component axon terminus, cytoplasm, ...
Function alpha-tubulin binding, beta-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (44)    Tissues (39)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(25) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000032668 (Evidence)
Ensembl Gene ModelENSMUSG00000034891 (Evidence)
Entrez Gene104069 (Evidence)
UniGene200843
DFCITC1581008
DoTSDT.486814
NIA Mouse Gene IndexU034804
Consensus CDS ProjectCCDS36670.1
International Mouse Knockout Project StatusSncb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032668 VEGA Gene Model | MGI Sequence Detail 7736 C57BL/6J ±  kb
transcript OTTMUST00000081255 VEGA | MGI Sequence Detail 1351 Not Applicable 
polypeptide OTTMUSP00000043434 VEGA | MGI Sequence Detail 133 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002461 Beta-synuclein
InterPro IPR001058 Synuclein
Protein Ontology PR:000015324 beta-synuclein
References
(Earliest) J:50153 Lavedan C, The synuclein family. Genome Res. 1998 Sep;8(9):871-80
(Latest) J:192811 Winner B, et al., Role of alpha-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci. 2012 Nov 21;32(47):16906-16
All references(47)
Other
accession IDs
MGI:2138328

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory