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Ttyh1
Gene Detail
Symbol

Name
ID
Ttyh1
tweety homolog 1 (Drosophila)
MGI:1889007
Synonyms
4930459B04Rik, 6330408P11Rik, tty
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.38 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:4119408-4136706 bp, + strand
From VEGA annotation of GRCm38

  17299 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TTYH1
Gene Tree: Ttyh1

Human
homologs
TTYH1, tweety family member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57348
neXtProt AC: NX_Q9H313

Human Chr (Location): 19q13.4; chr19:54415426-54436719 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality before implantation with arrest before the blastocyst stage and mitotic failure.
 
Interactions
Ttyh1 interacts with 279 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell adhesion, cell-substrate adhesion, ...
Component axon, chloride channel complex, ...
Function calcium ion binding, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (323)    Tissues (119)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 323
cDNA source data(77)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ttyh1    NEW 
Molecular
reagents
All nucleic(80) cDNA(79) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000021913 (Evidence)
Ensembl Gene Model ENSMUSG00000030428 (Evidence)
Entrez Gene 57776 (Evidence)
UniGene 29729
DFCI TC1574942, TC1592250, TC1594879, TC1601572, TC1728666, TC1741871
DoTS DT.101196643, DT.101736686, DT.102556129, DT.103584294, DT.103584407, DT.50316645, DT.91321979, DT.91348555, DT.94260126
NIA Mouse Gene Index U007610
Consensus CDS Project CCDS20730.1, CCDS51970.1
International Mouse Phenotyping Consortium Status Ttyh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021913 VEGA Gene Model | MGI Sequence Detail 17299 C57BL/6J ±  kb
transcript OTTMUST00000052035 VEGA | MGI Sequence Detail 2882 Not Applicable 
polypeptide OTTMUSP00000024584 VEGA | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006990 Tweety
Protein Ontology PR:000016803 protein tweety homolog 1
References
(Earliest) J:64127 Campbell HD, et al., Human and mouse homologues of the drosophila melanogaster tweety (tty) gene: A novel gene family encoding predicted transmembrane proteins. Genomics. 2000 Aug 15;68(1):89-92
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)
Other
accession IDs
MGI:1914663, MGI:1921927

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory