About   Help   FAQ
Fxyd4 Gene Detail
Summary
  • Symbol
    Fxyd4
  • Name
    FXYD domain-containing ion transport regulator 4
  • Synonyms
    0610008I02Rik, Chif
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889005
    NCBI Gene: 108017
Location & Maps
more
  • Sequence Map
    Chr6:117933559-117937692 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4134 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 55.70 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FXYD4, FXYD domain containing ion transport regulator 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    FXYD4, FXYD domain containing ion transport regulator 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CHIF
  • Links
    NCBI Gene ID: 53828
    neXtProt AC: NX_P59646

  • Chr Location
    10q11.21; chr10:43371644-43376335 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
Mice homozygous for a targeted null mutation are viable and fertile but exhibit a significant increase in urine volume (and water intake) under Na+ deprivation and K+ loading, as well as lethality after a combination of high-K+ intake and furosemide injection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056757 VEGA Gene Model | MGI Sequence Detail 4134 C57BL/6J ±  kb
transcript OTTMUST00000140055 VEGA | MGI Sequence Detail 586 Not Applicable  
polypeptide OTTMUSP00000073456 VEGA | MGI Sequence Detail 99 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030339 FXYD domain-containing ion transport regulator 4
  • InterPro Domains
    IPR000272 Ion-transport regulator, FXYD motif
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 2
Other
Accession IDs
less
MGI:1889805, MGI:1925611
References
more
  • Summaries
    All 34
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:64123 Sweadner KJ, et al., The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics. 2000 Aug 15;68(1):41-56
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory