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Wdr4 Gene Detail
Summary
  • Symbol
    Wdr4
  • Name
    WD repeat domain 4
  • Synonyms
    D530049K22Rik, Wh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889002
    NCBI Gene: 57773
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:31713296-31738946 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 16.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889002
protein coding gene Chr17:31713296-31738954 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023489
protein coding gene Chr17:31273136-31300883 (-)
A/J MGP_AJ_G0023447
protein coding gene Chr17:30241318-30267074 (-)
AKR/J MGP_AKRJ_G0023412
protein coding gene Chr17:30504224-30529902 (-)
BALB/cJ MGP_BALBcJ_G0023452
protein coding gene Chr17:30337015-30363073 (-)
C3H/HeJ MGP_C3HHeJ_G0023213
protein coding gene Chr17:30880757-30909276 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023894
protein coding gene Chr17:32349945-32375551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021368
protein coding gene Chr17:27367301-27393551 (-)
CAST/EiJ MGP_CASTEiJ_G0022714
protein coding gene Chr17:30927709-30954044 (-)
CBA/J MGP_CBAJ_G0023188
protein coding gene Chr17:33754544-33782721 (-)
DBA/2J MGP_DBA2J_G0023318
protein coding gene Chr17:29642428-29668473 (-)
FVB/NJ MGP_FVBNJ_G0023288
protein coding gene Chr17:29434827-29462028 (-)
LP/J MGP_LPJ_G0023396
protein coding gene Chr17:31492581-31519157 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023306
protein coding gene Chr17:32835351-32865436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023936
protein coding gene Chr17:30869767-30897454 (-)
PWK/PhJ MGP_PWKPhJ_G0022464
protein coding gene Chr17:28511284-28537773 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022282
protein coding gene Chr17:28851772-28882050 (-)
WSB/EiJ MGP_WSBEiJ_G0022776
protein coding gene Chr17:30828745-30855436 (-)



Homology
more
  • Human Ortholog
    WDR4, WD repeat domain 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR4, WD repeat domain 4
  • Synonyms
    GAMOS6, hWH, MIGSB, TRM82, TRMT82, Wuho
  • Links
    NCBI Gene ID: 10785
    neXtProt AC: NX_P57081
    UniProt: P57081

  • Chr Location
    21q22.3; chr21:42843094-42892998 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human WDR4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display lethality during organogenesis with increased apoptosis and DNA damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57773 NCBI Gene Model | MGI Sequence Detail 25651 C57BL/6J ±  kb
    transcript NM_001405114 RefSeq | MGI Sequence Detail 4096 C57BL/6  
    polypeptide Q9EP82 UniProt | EBI | MGI Sequence Detail 413 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000017392 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
    • InterPro Domains
      IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
      IPR028884 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 71
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1926109, MGI:2146843, MGI:2146859
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 4
      Diseases 3
      Gene Ontology 4
      Phenotypes 35
    • Earliest
      J:64125 Michaud J, et al., Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. Genomics. 2000 Aug 15;68(1):71-9
    • Latest
      J:344526 Wu PR, et al., Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation. Cell Death Dis. 2023 Jan 21;14(1):52

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory