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Wdr4 Gene Detail
Summary
  • Symbol
    Wdr4
  • Name
    WD repeat domain 4
  • Synonyms
    D530049K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889002
    NCBI Gene: 57773
Location & Maps
more
  • Sequence Map
    Chr17:31494323-31519974 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25652 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    WDR4, WD repeat domain 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDR4, WD repeat domain 4
    Orthology source: HomoloGene
  • Synonyms
    TRM82, TRMT82
  • Links
    NCBI Gene ID: 10785
    neXtProt AC: NX_P57081

  • Chr Location
    21q22.3; chr21:42843080-42879589 (-)  GRCh38.p2

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotype references
  • All Mutations and Alleles
    27
  • Gene trapped
    20
  • Targeted
    7
  • Genomic Mutations
    4 involving Wdr4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035223 VEGA Gene Model | MGI Sequence Detail 25652 C57BL/6J ±  kb
transcript OTTMUST00000089762 VEGA | MGI Sequence Detail 4153 Not Applicable  
polypeptide OTTMUSP00000049086 VEGA | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    111 from dbSNP Build 137
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017392 tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
  • InterPro Domains
    IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
    IPR028884 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit, Trm82
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 73
    cDNA 70
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGI:1926109, MGI:2146843, MGI:2146859
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 3
    Phenotypes 17
  • Earliest
    J:64125 Michaud J, et al., Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. Genomics. 2000 Aug 15;68(1):71-9
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory