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Wdr4 Gene Detail
Summary
  • Symbol
    Wdr4
  • Name
    WD repeat domain 4
  • Synonyms
    D530049K22Rik, Wh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889002
    NCBI Gene: 57773
  • Gene Overview
    MyGene.info: WDR4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:31494323-31519974 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 16.56 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889002
protein coding gene Chr17:31494322-31519991 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023489
protein coding gene Chr17:31273136-31300883 (-)
A/J MGP_AJ_G0023447
protein coding gene Chr17:30241318-30267074 (-)
AKR/J MGP_AKRJ_G0023412
protein coding gene Chr17:30504224-30529902 (-)
BALB/cJ MGP_BALBcJ_G0023452
protein coding gene Chr17:30337015-30363073 (-)
C3H/HeJ MGP_C3HHeJ_G0023213
protein coding gene Chr17:30880757-30909276 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023894
protein coding gene Chr17:32349945-32375551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021368
protein coding gene Chr17:27367301-27393551 (-)
CAST/EiJ MGP_CASTEiJ_G0022714
protein coding gene Chr17:30927709-30954044 (-)
CBA/J MGP_CBAJ_G0023188
protein coding gene Chr17:33754544-33782721 (-)
DBA/2J MGP_DBA2J_G0023318
protein coding gene Chr17:29642428-29668473 (-)
FVB/NJ MGP_FVBNJ_G0023288
protein coding gene Chr17:29434827-29462028 (-)
LP/J MGP_LPJ_G0023396
protein coding gene Chr17:31492581-31519157 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023306
protein coding gene Chr17:32835351-32865436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023936
protein coding gene Chr17:30869767-30897454 (-)
PWK/PhJ MGP_PWKPhJ_G0022464
protein coding gene Chr17:28511284-28537773 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022282
protein coding gene Chr17:28851772-28882050 (-)
WSB/EiJ MGP_WSBEiJ_G0022776
protein coding gene Chr17:30828745-30855436 (-)



Homology
more
  • Human Ortholog
    WDR4, WD repeat domain 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDR4, WD repeat domain 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TRM82, TRMT82
  • Links
    NCBI Gene ID: 10785
    neXtProt AC: NX_P57081
    UniProt: P57081

  • Chr Location
    21q22.3; chr21:42843075-42879865 (-)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display lethality during organogenesis with increased apoptosis and DNA damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024037 Ensembl Gene Model | MGI Sequence Detail 25652 C57BL/6J ±  kb
transcript ENSMUST00000171171 Ensembl | MGI Sequence Detail 4153 Not Applicable  
polypeptide ENSMUSP00000126061 Ensembl | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
    IPR028884 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
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  • All nucleic 74
    cDNA 71
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGI:1926109, MGI:2146843, MGI:2146859
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Diseases 3
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:64125 Michaud J, et al., Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. Genomics. 2000 Aug 15;68(1):71-9
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory