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Nub1 Gene Detail
Summary
  • Symbol
    Nub1
  • Name
    negative regulator of ubiquitin-like proteins 1
  • Synonyms
    4931404D21Rik, 6330412F12Rik, BS4, NY-REN-18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889001
    NCBI Gene: 53312
  • Gene Overview
    MyGene.info: NUB1
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24685815-24710378 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 11.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889001
 protein coding gene Chr5:24685532-24710378 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029353
 protein coding gene Chr5:22447755-22473331 (+)
A/J MGP_AJ_G0029319
 protein coding gene Chr5:21661336-21690647 (+)
AKR/J MGP_AKRJ_G0029270
 protein coding gene Chr5:22539682-22564611 (+)
BALB/cJ MGP_BALBcJ_G0029330
 protein coding gene Chr5:22176882-22201726 (+)
C3H/HeJ MGP_C3HHeJ_G0029050
 protein coding gene Chr5:22651181-22676100 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029783
 protein coding gene Chr5:23941878-23968176 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027021
 protein coding gene Chr5:19597926-19622072 (+)
CAST/EiJ MGP_CASTEiJ_G0028462
 protein coding gene Chr5:21840655-21867617 (+)
CBA/J MGP_CBAJ_G0029017
 protein coding gene Chr5:24345075-24372394 (+)
DBA/2J MGP_DBA2J_G0029168
 protein coding gene Chr5:21955352-21978604 (+)
FVB/NJ MGP_FVBNJ_G0029126
 protein coding gene Chr5:21332066-21356908 (+)
LP/J MGP_LPJ_G0029252
 protein coding gene Chr5:22843269-22867987 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029155
 protein coding gene Chr5:25442229-25469335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029817
 protein coding gene Chr5:22188367-22213217 (+)
PWK/PhJ MGP_PWKPhJ_G0028186
 protein coding gene Chr5:21050102-21073769 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028017
 protein coding gene Chr5:21534316-21562452 (+)
WSB/EiJ MGP_WSBEiJ_G0028542
 protein coding gene Chr5:22261078-22286853 (+)



Homology
more
  • Human Ortholog
    NUB1, negative regulator of ubiquitin like proteins 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NUB1, negative regulator of ubiquitin like proteins 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BS4, NUB1L, NYREN18
  • Links
    NCBI Gene ID: 51667
    neXtProt AC: NX_Q9Y5A7
    UniProt: Q9Y5A7

  • Chr Location
    7q36.1; chr7:151341699-151378461 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 41108
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NUB1
  • Gene Tree
    Nub1
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    10
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Nub1
  • Find Mice (IMSR)
    10 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    33
  • Tissues
    9
  • cDNA Data
    9
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 53312 NCBI Gene Model | MGI Sequence Detail 24564 C57BL/6J ±  kb
transcript NM_016736 RefSeq | MGI Sequence Detail 3293 C57BL/6  
polypeptide P54729 UniProt | EBI | MGI Sequence Detail 614 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • PDB
    1VEG
  • InterPro Domains
    IPR039749 NEDD8 ultimate buster 1
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR009060 UBA-like superfamily
    IPR015940 Ubiquitin-associated domain
    IPR029071 Ubiquitin-like domain superfamily
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 6
Other
Accession IDs
less
MGI:1921250, MGI:1926009
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 1
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:233339 Tanji K, et al., The role of NUB1 in alpha-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016 Feb 12;470(3):635-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/08/2019
MGI 6.13 		The Jackson Laboratory