Nub1 Gene Detail

Summary

• Symbol
  Nub1
• Name
  negative regulator of ubiquitin-like proteins 1
• Synonyms
  4931404D21Rik, 6330412F12Rik, BS4, NY-REN-18

• Feature Type
  protein coding gene
• IDs
  MGI:1889001
  NCBI Gene: 53312
• Gene Overview
  MyGene.info: NUB1
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr5:24685815-24710378 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 11.93 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  293 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1889001	protein coding gene	Chr5:24685532-24710378 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0029353	protein coding gene	Chr5:22447755-22473331 (+)
A/J	MGP_AJ_G0029319	protein coding gene	Chr5:21661336-21690647 (+)
AKR/J	MGP_AKRJ_G0029270	protein coding gene	Chr5:22539682-22564611 (+)
BALB/cJ	MGP_BALBcJ_G0029330	protein coding gene	Chr5:22176882-22201726 (+)
C3H/HeJ	MGP_C3HHeJ_G0029050	protein coding gene	Chr5:22651181-22676100 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029783	protein coding gene	Chr5:23941878-23968176 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027021	protein coding gene	Chr5:19597926-19622072 (+)
CAST/EiJ	MGP_CASTEiJ_G0028462	protein coding gene	Chr5:21840655-21867617 (+)
CBA/J	MGP_CBAJ_G0029017	protein coding gene	Chr5:24345075-24372394 (+)
DBA/2J	MGP_DBA2J_G0029168	protein coding gene	Chr5:21955352-21978604 (+)
FVB/NJ	MGP_FVBNJ_G0029126	protein coding gene	Chr5:21332066-21356908 (+)
LP/J	MGP_LPJ_G0029252	protein coding gene	Chr5:22843269-22867987 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029155	protein coding gene	Chr5:25442229-25469335 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029817	protein coding gene	Chr5:22188367-22213217 (+)
PWK/PhJ	MGP_PWKPhJ_G0028186	protein coding gene	Chr5:21050102-21073769 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028017	protein coding gene	Chr5:21534316-21562452 (+)
WSB/EiJ	MGP_WSBEiJ_G0028542	protein coding gene	Chr5:22261078-22286853 (+)

Homology

• Human Ortholog
  NUB1, negative regulator of ubiquitin like proteins 1

• Vertebrate Orthologs
  10

• Human Ortholog
  NUB1, negative regulator of ubiquitin like proteins 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  BS4, NUB1L, NYREN18
• Links
  HGNC:17623

  NCBI Gene ID: 51667

  neXtProt AC: NX_Q9Y5A7

  UniProt: Q9Y5A7

  
  
• Chr Location
  7q36.1; chr7:151341699-151378461 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 41108
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: NUB1
• Gene Tree
  Nub1
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotype references
  

• All Mutations and Alleles
  17
• Chemically induced (other)
  2
• Gene trapped
  10
• Radiation induced
  1
• Spontaneous
  1
• Targeted
  3
• Genomic Mutations
  4 involving Nub1
• Find Mice (IMSR)
  10 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  1

• External Resources
  FuncBase

Expression

• Assay Results
  33
• Tissues
  9
• cDNA Data
  9
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase nub1

Interactions

• Nub1 interacts with 171 markers (Mir1a-1, Mir1a-2, Mir17, ...) View All

Sequences &
Gene Models

• All Sequences
  57
• RefSeq
  4
• UniProt
  5
• CCDS
  CCDS39030.1, CCDS80230.1

• Ensembl
  ENSMUSG00000028954 (Evidence)
• NCBI Gene
  53312

Representative Sequences			Length	Strain/Species
genomic	53312	NCBI Gene Model | MGI Sequence Detail	24564	C57BL/6J
transcript	NM_016736	RefSeq | MGI Sequence Detail	3293	C57BL/6
polypeptide	P54729	UniProt | EBI | MGI Sequence Detail	614	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• PDB
  1VEG
• InterPro Domains
  IPR011990 Tetratricopeptide-like helical domain superfamily
  IPR009060 UBA-like superfamily
  IPR015940 Ubiquitin-associated domain
  IPR029071 Ubiquitin-like domain superfamily

Molecular
Reagents

• All nucleic 11

  cDNA 11

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:1921250, MGI:1926009

References

• Summaries
  All 38

  Developmental Gene Expression 3

  Diseases 1

  Gene Ontology 1

  Phenotypes 16
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:233339 Tanji K, et al., The role of NUB1 in alpha-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016 Feb 12;470(3):635-42

TSS for Nub1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45443	Chr5:24685815-24685819 (+)	2 bp
Tssr45444	Chr5:24685833-24685853 (+)	28 bp
Tssr45445	Chr5:24685954-24686004 (+)	164 bp
Tssr45446	Chr5:24697076-24697094 (+)	11,270 bp
Tssr45447	Chr5:24709062-24709079 (+)	23,256 bp
Tssr45448	Chr5:24709567-24709591 (+)	23,764 bp