Nub1 MGI Mouse Gene Detail - MGI:1889001 - negative regulator of ubiquitin-like proteins 1

Nub1 Gene Detail

Symbol

Nub1
Name

negative regulator of ubiquitin-like proteins 1
Synonyms

4931404D21Rik, 6330412F12Rik, BS4, NY-REN-18

Feature Type

protein coding gene
IDs

MGI:1889001
NCBI Gene: 53312
Gene Overview

MyGene.info: NUB1

Sequence Map

Chr5:24685532-24710378 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

24847 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 11.93 cM
Mapping Data

1 experiment

Human Ortholog

NUB1, negative regulator of ubiquitin like proteins 1

Vertebrate Orthologs

10

Human Ortholog

NUB1, negative regulator of ubiquitin like proteins 1
Orthology source: HomoloGene, HGNC
Synonyms

BS4, NUB1L, NYREN18
Links

HGNC:17623

NCBI Gene ID: 51667

neXtProt AC: NX_Q9Y5A7

UniProt: Q9Y5A7
Chr Location

7q36.1; chr7:151341699-151378461 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41108
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NUB1
Gene Tree

Nub1

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References

1 with disease annotations

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Phenotype Summary

16 phenotype references

All Mutations and Alleles

17
Chemically induced (other)

2
Gene trapped

10
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Nub1
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

6
GO References

1

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

33
Tissues

9
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nub1

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Nub1 interacts with 171 markers (Mir1a-1, Mir1a-2, Mir17, ...) View All

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All Sequences

46
RefSeq

4
UniProt

5
CCDS

CCDS39030.1, CCDS80230.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000053708	VEGA Gene Model \| MGI Sequence Detail	24847	C57BL/6J	± kb
transcript	OTTMUST00000133737	VEGA \| MGI Sequence Detail	3546	Not Applicable
polypeptide	OTTMUSP00000071028	VEGA \| MGI Sequence Detail	638	Not Applicable

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SNPs within 2kb

293 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000011475 NEDD8 ultimate buster 1

(term hierarchy)
PDB

1VEG
InterPro Domains

IPR011990 Tetratricopeptide-like helical domain

IPR009060 UBA-like

IPR015940 Ubiquitin-associated domain

IPR029071 Ubiquitin-related domain

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All nucleic 10

cDNA 10

Microarray probesets 6

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MGI:1921250, MGI:1926009

Summaries

All 39

Developmental Gene Expression 3

Diseases 1

Gene Ontology 1

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:233339 Tanji K, et al., The role of NUB1 in alpha-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016 Feb 12;470(3):635-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/11/2017 MGI 6.10