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Cd59b
Gene Detail
Symbol

Name
ID
Cd59b
CD59b antigen
MGI:1888996
Feature Type
protein coding gene
Genetic Map
Chromosome 2
54.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:104069849-104091187 bp, + strand
From VEGA annotation of GRCm38

  21339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CD59
Protein SuperFamily: CD59 antigen
Gene Tree: Cd59b

Human
homologs
CD59, CD59 molecule, complement regulatory protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 966
neXtProt AC: NX_P13987

Human Synonyms: 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF20, HRF-20, MACIF, MAC-IP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20

Human Chr (Location): 11p13; chr11:33703010-33736479 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD59

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Genomic Mutations involving Cd59b (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation develop a severe hemolytic anemia and progressive male infertility.
 
Interactions
Cd59b interacts with 62 markers (Mir17, Mir20b, Mir26a-1, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (47)    Tissues (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Western blot 7
RT-PCR 36
cDNA source data(8)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: ZFIN cd59    NEW 
Molecular
reagents
All nucleic(13) cDNA(8) Primer pair(5)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000014926 (Evidence)
Ensembl Gene Model ENSMUSG00000068686 (Evidence)
Entrez Gene 333883 (Evidence)
UniGene 359026
DFCI TC1590915, TC1591405, TC1670855
DoTS DT.101283138, DT.94185596, DT.110714977
Consensus CDS Project CCDS16486.1
International Mouse Phenotyping Consortium Status Cd59b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014926 VEGA Gene Model | MGI Sequence Detail 21339 C57BL/6J ±  kb
transcript OTTMUST00000035460 VEGA | MGI Sequence Detail 434 Not Applicable 
polypeptide OTTMUSP00000015872 VEGA | MGI Sequence Detail 129 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(195 from dbSNP Build 137)    SNPs within 2kb including multiple locations(285)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR027101 CD59 glycoprotein
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000002000 CD59B glycoprotein
References
(Earliest) J:64057 Qian YM, et al., Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59. J Immunol. 2000 Sep 1;165(5):2528-34
(Latest) J:180268 Zhang J, et al., The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol. 2011 Dec;179(6):2876-84
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory