Cd59b
Gene Detail

Symbol Name ID

Cd59b CD59b antigen MGI:1888996

Feature Type

protein coding gene

Genetic Map

Chromosome 2

54.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:104069849-104091187 bp, + strand From VEGA annotation of GRCm38   21339 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56386  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: CD59 antigen
Gene Tree: Cd59b

Human homologs

Human Homolog		CD59, CD59 molecule, complement regulatory protein
NCBI Gene ID		966
neXtProt AC		NX_P13987
Human Synonyms		16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF20, HRF-20, MACIF, MAC-IP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
Human Chr (Location)		11p13; chr11:33724556-33758025 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD59

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

Mice homozygous for a targeted null mutation develop a severe hemolytic anemia and progressive male infertility.

 
Human Diseases Modeled Using Mouse Cd59b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	negative regulation of activation of membrane attack complex, negative regulation of apoptotic process, ...
Component	anchored to external side of plasma membrane, anchored to membrane, ...
Function	complement binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (47)    Tissues (10)   
Theiler Stages: 7, 16, 25, 28

Assay Type	Results
Immunohistochemistry	4
Western blot	7
RT-PCR	36

cDNA source data(9)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(9) Primer pair(5)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000014926 (Evidence)
Ensembl Gene Model	ENSMUSG00000068686 (Evidence)
Entrez Gene	333883 (Evidence)
UniGene	359026
DFCI	TC1590915, TC1591405, TC1670855
DoTS	DT.101283138, DT.110714977, DT.94185596
Consensus CDS Project	CCDS16486.1
International Mouse Knockout Project Status	Cd59b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014926	VEGA Gene Model | MGI Sequence Detail	21339	C57BL/6J
transcript	OTTMUST00000035460	VEGA | MGI Sequence Detail	434	Not Applicable
polypeptide	OTTMUSP00000015872	VEGA | MGI Sequence Detail	129	Not Applicable

All sequences(37) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(66 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001526	CD59 antigen
InterPro	IPR016054	Ly-6 antigen / uPA receptor -like
Protein Ontology	PR:000002000	CD59B glycoprotein

References

(Earliest) J:64057 Qian YM, et al., Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59. J Immunol. 2000 Sep 1;165(5):2528-34
(Latest) J:180268 Zhang J, et al., The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol. 2011 Dec;179(6):2876-84
All references(33)