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Fmnl1 Gene Detail
Summary
  • Symbol
    Fmnl1
  • Name
    formin-like 1
  • Synonyms
    8030453N10Rik, formin-related gene in leukocytes
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888994
    NCBI Gene: 57778
  • Gene Overview
    MyGene.info: FMNL1
Location & Maps
more
  • Sequence Map
    Chr11:103171107-103198901 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      27795 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 66.71 cM, cytoband D
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FMNL1, formin like 1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    FMNL1, formin like 1
    Orthology source: HGNC
  • Synonyms
    C17orf1, C17orf1B, FHOD4, FMNL, KW-13
  • Links
    NCBI Gene ID: 752
    neXtProt AC: NX_O95466

  • Chr Location
    17q21; chr17:45221906-45247320 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Fmnl1
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    34
  • Tissues
    20
  • cDNA Data
    6
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003031 VEGA Gene Model | MGI Sequence Detail 27795 C57BL/6J ±  kb
transcript OTTMUST00000006216 VEGA | MGI Sequence Detail 3806 Not Applicable  
polypeptide OTTMUSP00000002931 VEGA | MGI Sequence Detail 1094 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    95 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 6
    Primer pair 1
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:1924425, MGI:2144223
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:64031 Yayoshi-Yamamoto S, et al., FRL, a novel formin-related protein, binds to rac and regulates cell motility and survival of macrophages. Mol Cell Biol. 2000 Sep;20(18):6872-81
  • Latest
    J:226856 Dutta P, et al., Expression of multiple formins in adult tissues and during developmental stages of mouse brain. Gene Expr Patterns. 2015 Sep-Nov;19(1-2):52-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory