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Fmnl1 Gene Detail
Summary
  • Symbol
    Fmnl1
  • Name
    formin-like 1
  • Synonyms
    8030453N10Rik, formin-related gene in leukocytes
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888994
    NCBI Gene: 57778
  • Gene Overview
    MyGene.info: FMNL1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:103171107-103198901 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.71 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888994
protein coding gene Chr11:103170575-103198901 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019258
protein coding gene Chr11:106226999-106256470 (+)
A/J MGP_AJ_G0019226
protein coding gene Chr11:101719027-101747675 (+)
AKR/J MGP_AKRJ_G0019195
protein coding gene Chr11:104853530-104881334 (+)
BALB/cJ MGP_BALBcJ_G0019200
protein coding gene Chr11:102185900-102214453 (+)
C3H/HeJ MGP_C3HHeJ_G0019009
protein coding gene Chr11:105081409-105109166 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019649
protein coding gene Chr11:109532707-109560386 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017275
protein coding gene Chr11:99128656-99156079 (+)
CAST/EiJ MGP_CASTEiJ_G0018563
protein coding gene Chr11:106095214-106128854 (+)
CBA/J MGP_CBAJ_G0018978
protein coding gene Chr11:114085173-114114480 (+)
DBA/2J MGP_DBA2J_G0019090
protein coding gene Chr11:101226164-101253879 (+)
FVB/NJ MGP_FVBNJ_G0019080
protein coding gene Chr11:100769865-100798123 (+)
LP/J MGP_LPJ_G0019159
protein coding gene Chr11:106738692-106766437 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019111
protein coding gene Chr11:113462323-113492617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019687
protein coding gene Chr11:105238102-105265924 (+)
PWK/PhJ MGP_PWKPhJ_G0018326
protein coding gene Chr11:102297751-102326522 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018118
protein coding gene Chr11:104989314-105016621 (+)
WSB/EiJ MGP_WSBEiJ_G0018612
protein coding gene Chr11:105234924-105263977 (+)



Homology
more
  • Human Ortholog
    FMNL1, formin like 1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    FMNL1, formin like 1
    Orthology source: HGNC
  • Synonyms
    C17orf1, C17orf1B, FHOD4, FMNL, KW-13
  • Links
    NCBI Gene ID: 752
    neXtProt AC: NX_O95466
    UniProt: O95466

  • Chr Location
    17q21.31; chr17:45221728-45247322 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Constitutive homozygous KO is embryonic lethal. Conditional homozygous KO in myeloid cells leads to reduced macrophage migration and podosome formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055805 Ensembl Gene Model | MGI Sequence Detail 27795 C57BL/6J ±  kb
transcript ENSMUST00000218163 Ensembl | MGI Sequence Detail 3824 Not Applicable  
polypeptide ENSMUSP00000151439 Ensembl | MGI Sequence Detail 1100 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1924425, MGI:2144223
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:250144 Miller MR, et al., Non-canonical activity of the podosomal formin FMNL1gamma supports immune cell migration. J Cell Sci. 2017 May 15;130(10):1730-1739

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory