Dlg3
Gene Detail

Symbol

Name
ID

Dlg3
discs, large homolog 3 (Drosophila)
MGI:1888986

Synonyms

DLG3, Dlgh3, mKIAA1232, SAP102

Feature Type

protein coding gene

Genetic Map

Chromosome X
43.72 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:100767722-100818410 bp, + strand From VEGA annotation of GRCm38   50689 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:41157  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg3

Human
homologs

Human Homolog		DLG3, discs, large homolog 3 (Drosophila)
NCBI Gene ID		1741
neXtProt AC		NX_Q92796
Human Synonyms		MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR
Human Chr (Location)		Xq13.1; chrX:70444855-70505493 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human DLG3

Mutations,
alleles, and
phenotypes

All mutations/alleles(31) : Gene trapped(26) Targeted(5)
Incidental mutations (data from APF )
 

Male mice hemizygous for a knock-out allele show alterations in spatial learning, locomotor activation, LTP, and spike-timing-dependent plasticity. A portion of chimeras hemizygous for a gene trapped allele display forebrain deletion, posterior truncation, and failure to initiate embryo turning.

 
Phenotype Images(3)

Interactions

Dlg3 interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (41 annotations)

Process	embryo development, establishment of planar polarity, ...
Component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, basolateral plasma membrane, ...
Function	guanylate kinase activity, ionotropic glutamate receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (45)    Tissues (32)    Images (13)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	41
RT-PCR	4

cDNA source data(78)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(80) Genomic(1) cDNA(78) Primer pair(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000016499 (Evidence)
Ensembl Gene Model	ENSMUSG00000000881 (Evidence)
Entrez Gene	53310 (Evidence)
UniGene	4615
DFCI	TC1603357, TC1576835, TC1696283, TC1609609
DoTS	DT.111036051, DT.101394280, DT.101362297, DT.101297978, DT.530515, DT.91359338
NIA Mouse Gene Index	U020060
Consensus CDS Project	CCDS30307.1, CCDS53148.1, CCDS53149.1, CCDS72413.1
International Mouse Knockout Project Status	Dlg3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016499	VEGA Gene Model | MGI Sequence Detail	50689	C57BL/6J
transcript	OTTMUST00000039843	VEGA | MGI Sequence Detail	4956	Not Applicable
polypeptide	OTTMUSP00000017771	VEGA | MGI Sequence Detail	849	Not Applicable

All sequences(78) RefSeq(18) UniProt(5)

Polymorphisms

SNPs within 2kb(84 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008144	Guanylate kinase
InterPro	IPR020590	Guanylate kinase, conserved site
InterPro	IPR008145	Guanylate kinase/L-type calcium channel
InterPro	IPR019590	Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro	IPR016313	Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro	IPR019583	PDZ-associated domain of NMDA receptors
InterPro	IPR001478	PDZ domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000006513	disks large homolog 3

References

(Earliest) J:48003 Lin L, et al., cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):211-6
(Latest) J:215971 Gegg M, et al., Flattop regulates basal body docking and positioning in mono- and multiciliated cells. Elife. 2014;3
All references(60)