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Dlg3 Gene Detail
Summary
  • Symbol
    Dlg3
  • Name
    discs large MAGUK scaffold protein 3
  • Synonyms
    DLG3, Dlgh3, mKIAA1232, SAP102
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888986
    NCBI Gene: 53310
  • Gene Overview
    MyGene.info: DLG3
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100767722-100818410 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 43.72 cM, cytoband C2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888986
 protein coding gene ChrX:100767408-100818410 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035949
 protein coding gene ChrX:97236261-97291398 (+)
A/J MGP_AJ_G0035934
 protein coding gene ChrX:97266145-97320566 (+)
AKR/J MGP_AKRJ_G0035850
 protein coding gene ChrX:100059321-100113275 (+)
BALB/cJ MGP_BALBcJ_G0035917
 protein coding gene ChrX:96007053-96059507 (+)
C3H/HeJ MGP_C3HHeJ_G0035626
 protein coding gene ChrX:97655119-97711922 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036446
 protein coding gene ChrX:100137462-100193121 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033276
 protein coding gene ChrX:95038989-95089905 (+)
CAST/EiJ MGP_CASTEiJ_G0034913
 protein coding gene ChrX:81961882-82016217 (+)
CBA/J MGP_CBAJ_G0035601
 protein coding gene ChrX:103240215-103297551 (+)
DBA/2J MGP_DBA2J_G0035755
 protein coding gene ChrX:96469023-96528136 (+)
FVB/NJ MGP_FVBNJ_G0035693
 protein coding gene ChrX:95865155-95915273 (+)
LP/J MGP_LPJ_G0035845
 protein coding gene ChrX:98210875-98268077 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035728
 protein coding gene ChrX:107769505-107827323 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036473
 protein coding gene ChrX:96945552-97003035 (+)
PWK/PhJ MGP_PWKPhJ_G0034612
 protein coding gene ChrX:79577763-79630890 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034440
 protein coding gene ChrX:82851744-82907203 (+)
WSB/EiJ MGP_WSBEiJ_G0035052
 protein coding gene ChrX:95656239-95712533 (+)



Homology
more
  • Human Ortholog
    DLG3, discs large MAGUK scaffold protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DLG3, discs large MAGUK scaffold protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR
  • Links
    NCBI Gene ID: 1741
    neXtProt AC: NX_Q92796
    UniProt: Q92796

  • Chr Location
    Xq13.1; chrX:70444850-70505490 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Dlg3 mouse models; 1 with human DLG3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele show alterations in spatial learning, locomotor activation, LTP, and spike-timing-dependent plasticity. A portion of chimeras hemizygous for a gene trapped allele display forebrain deletion, posterior truncation, and failure to initiate embryo turning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    45
  • Tissues
    32
  • cDNA Data
    78
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000881 Ensembl Gene Model | MGI Sequence Detail 50689 C57BL/6J ±  kb
    transcript ENSMUST00000087984 Ensembl | MGI Sequence Detail 4956 Not Applicable  
    polypeptide ENSMUSP00000085299 Ensembl | MGI Sequence Detail 849 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 2
      cDNA 78
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 18
      Phenotypes 20
    • Earliest
      J:48003 Lin L, et al., cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):211-6
    • Latest
      J:249721 Li J, et al., Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nat Neurosci. 2017 Aug;20(8):1150-1161
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/08/2019
    MGI 6.13     		The Jackson Laboratory