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Dlg3
Gene Detail
 Symbol
Name
ID
Dlg3
discs, large homolog 3 (Drosophila)
MGI:1888986
Synonyms DLG3, Dlgh3, mKIAA1232, SAP102
Feature Type protein coding gene
Genetic Map
Chromosome X
43.72 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:100767722-100818410 bp, + strand
From VEGA annotation of GRCm38

  50689 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41157  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg3

Human
homologs
Human Homolog DLG3, discs, large homolog 3 (Drosophila)
NCBI Gene ID 1741
neXtProt AC  NX_Q92796
Human Synonyms  MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR
Human Chr (Location)  Xq13.1; chrX:70444855-70505493 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DLG3
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(26) Targeted(5)
Incidental mutations (data from APF )
 
Male mice hemizygous for a knock-out allele show alterations in spatial learning, locomotor activation, LTP, and spike-timing-dependent plasticity. A portion of chimeras hemizygous for a gene trapped allele display forebrain deletion, posterior truncation, and failure to initiate embryo turning.
 
Phenotype Images(3)
Interactions
Dlg3 interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process establishment of planar polarity, establishment or maintenance of epithelial cell apical/basal polarity, ...
Component alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, cell-cell junction, ...
Function ionotropic glutamate receptor binding, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (45)    Tissues (32)    Images (13)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 41
RT-PCR 4
cDNA source data(78)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) Genomic(1) cDNA(78) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016499 (Evidence)
Ensembl Gene ModelENSMUSG00000000881 (Evidence)
Entrez Gene53310 (Evidence)
UniGene4615
DFCITC1576835, TC1603357, TC1609609, TC1696283
DoTSDT.101297978, DT.101362297, DT.101394280, DT.111036051, DT.530515, DT.91359338
NIA Mouse Gene IndexU020060
Consensus CDS ProjectCCDS30307.1, CCDS53148.1, CCDS53149.1, CCDS72413.1
International Mouse Knockout Project StatusDlg3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016499 VEGA Gene Model | MGI Sequence Detail 50689 C57BL/6J ±  kb
transcript OTTMUST00000039843 VEGA | MGI Sequence Detail 4956 Not Applicable 
polypeptide OTTMUSP00000017771 VEGA | MGI Sequence Detail 849 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(18) UniProt(5)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro IPR016313 Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro IPR019583 PDZ-associated domain of NMDA receptors
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000006513 disks large homolog 3
References (Earliest) J:48003 Lin L, et al., cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):211-6
(Latest) J:198011 Eom T, et al., NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013;2:e00178
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory