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Dlg3 Gene Detail
Summary
  • Symbol
    Dlg3
  • Name
    discs large MAGUK scaffold protein 3
  • Synonyms
    DLG3, Dlgh3, mKIAA1232, SAP102
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888986
    NCBI Gene: 53310
  • Gene Overview
    MyGene.info: DLG3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    ChrX:100767722-100818410 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      50689 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 43.72 cM, cytoband C2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DLG3, discs large MAGUK scaffold protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DLG3, discs large MAGUK scaffold protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR
  • Links
    NCBI Gene ID: 1741
    neXtProt AC: NX_Q92796
    UniProt: Q92796

  • Chr Location
    Xq13.1; chrX:70444850-70505490 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Dlg3 mouse models; 1 with human DLG3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele show alterations in spatial learning, locomotor activation, LTP, and spike-timing-dependent plasticity. A portion of chimeras hemizygous for a gene trapped allele display forebrain deletion, posterior truncation, and failure to initiate embryo turning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    45
  • Tissues
    32
  • cDNA Data
    78
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016499 VEGA Gene Model | MGI Sequence Detail 50689 C57BL/6J ±  kb
    transcript OTTMUST00000039843 VEGA | MGI Sequence Detail 4956 Not Applicable  
    polypeptide OTTMUSP00000017771 VEGA | MGI Sequence Detail 849 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      84 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 2
      cDNA 78
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 17
      Phenotypes 20
    • Earliest
      J:48003 Lin L, et al., cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus. Biochim Biophys Acta. 1998 Nov 26;1443(1-2):211-6
    • Latest
      J:249721 Li J, et al., Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nat Neurosci. 2017 Aug;20(8):1150-1161
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory