Sept6
Gene Detail

Symbol Name ID

Sept6 septin 6 MGI:1888939

Synonyms

2810035H17Rik, C920001C06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome X

21.32 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:36911326-36991794 bp, - strand From VEGA annotation of GRCm38   80469 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:62617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: septin
Gene Tree: Sept6

Human homologs

Human Homolog		SEPT6, septin 6
NCBI Gene ID		23157
neXtProt AC		NX_Q14141
Human Synonyms		SEP2, SEPT2
Human Chr (Location)		Xq24; chrX:118749687-118827333 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygous females and hemizygous males harboring a knock-out mutation in this gene have a normal lifespan and display neither gross abnormalities, changes in cytokinesis, nor spontaneous malignancies including leukemia.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell cycle, cell division
Component	axon terminus, chromosome, ...
Function	GTP binding, nucleotide binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (27)    Tissues (27)    Images (8)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	27

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(19)
Microarray probesets(12)

Other database links

VEGA Gene Model	OTTMUSG00000017110 (Evidence)
Ensembl Gene Model	ENSMUSG00000050379 (Evidence)
Entrez Gene	56526 (Evidence)
NIA Mouse Gene Index	U069017, U211563
Consensus CDS Project	CCDS30066.1, CCDS53051.1, CCDS57749.1
International Mouse Knockout Project Status	Sept6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017110	VEGA Gene Model | MGI Sequence Detail	80469	C57BL/6J
transcript	OTTMUST00000041432	VEGA | MGI Sequence Detail	1845	Not Applicable
polypeptide	OTTMUSP00000018592	VEGA | MGI Sequence Detail	434	Not Applicable

All sequences(60) RefSeq(8) UniProt(3)

Polymorphisms

SNPs(105 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000038	Cell division protein GTP binding
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR016491	Septin
Protein Ontology	PR:000014658	septin-6

References

(Earliest) J:65529 Kinoshita A, et al., Differential localization of septins in the mouse brain. J Comp Neurol. 2000 Dec 11;428(2):223-39
(Latest) J:186260 Yoshida A, et al., Localization of septin proteins in the mouse cochlea. Hear Res. 2012 Jul;289(1-2):40-51
All references(42)

Other accession IDs

MGI:1919926, MGI:2443232