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Sept6 Gene Detail
Summary
  • Symbol
    Sept6
  • Name
    septin 6
  • Synonyms
    2810035H17Rik, C920001C06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888939
    NCBI Gene: 56526
  • Gene Overview
    MyGene.info: SEPT6
Location & Maps
more
  • Sequence Map
    ChrX:36911326-36991794 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80469 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SEPT6, septin 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SEPT6, septin 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SEP2, SEPT2
  • Links
    NCBI Gene ID: 23157
    neXtProt AC: NX_Q14141

  • Chr Location
    Xq24; chrX:119615724-119693370 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
Homozygous females and hemizygous males harboring a knock-out mutation in this gene have a normal lifespan and display neither gross abnormalities, changes in cytokinesis, nor spontaneous malignancies including leukemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017110 VEGA Gene Model | MGI Sequence Detail 80469 C57BL/6J ±  kb
transcript OTTMUST00000041432 VEGA | MGI Sequence Detail 1845 Not Applicable  
polypeptide OTTMUSP00000018592 VEGA | MGI Sequence Detail 434 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    122 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 19
    cDNA 19

    Microarray probesets 12
Other
Accession IDs
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MGI:1919926, MGI:2443232
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:65529 Kinoshita A, et al., Differential localization of septins in the mouse brain. J Comp Neurol. 2000 Dec 11;428(2):223-39
  • Latest
    J:205987 Ageta-Ishihara N, et al., Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Nat Commun. 2013;4:2532

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory